homoserine

ホモセリン

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/10/29 12:54:38」(JST)

wiki en

[Wiki en表示]

L-Homoserine
IUPAC name (S)-2-Amino-4-hydroxybutanoic acid
Identifiers
CAS number	672-15-1 Y
PubChem	779
ChemSpider	758 Y
EC-number	211-590-6
ChEBI	CHEBI:30653 Y
ChEMBL	CHEMBL11722 N
Jmol-3D images	Image 1
SMILES O=C(O)C(N)CCO
InChI InChI=1S/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8) Y Key: UKAUYVFTDYCKQA-UHFFFAOYSA-N Y InChI=1/C4H9NO3/c5-3(1-2-6)4(7)8/h3,6H,1-2,5H2,(H,7,8) Key: UKAUYVFTDYCKQA-UHFFFAOYAZ
Properties
Molecular formula	C4H9NO3
Molar mass	119.12 g/mol
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Homoserine (also called isothreonine) is an α-amino acid with the chemical formula HO₂CCH(NH₂)CH₂CH₂OH. L-Homoserine is not one of the common amino acids encoded by DNA. It differs from the proteinogenic amino acid serine by insertion of an additional -CH₂- unit into the backbone. Homoserine, or its lactone form, is the product of a cyanogen bromide cleavage of a peptide by degradation of methionine.

Homoserine is an intermediate in the biosynthesis of three essential amino acids: methionine, threonine (an isomer of homoserine), and isoleucine. It forms by two reductions of aspartic acid via the intermediacy of aspartate semialdehyde.

References

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 高IgD症候群：病態生理 hyperimmunoglobulin d syndrome pathophysiology

English Journal

• Nitrite-Oxidizing Bacterium Nitrobacter winogradskyi Produces N-Acyl-Homoserine Lactone Autoinducers.

• Mellbye BL1, Bottomley PJ2, Sayavedra-Soto LA1.
• Applied and environmental microbiology.Appl Environ Microbiol.2015 Sep 1;81(17):5917-26. doi: 10.1128/AEM.01103-15. Epub 2015 Jun 19.
• Nitrobacter winogradskyi is a chemolithotrophic bacterium that plays a role in the nitrogen cycle by oxidizing nitrite to nitrate. Here, we demonstrate a functional N-acyl-homoserine lactone (acyl-HSL) synthase in this bacterium. The N. winogradskyi genome contains genes encoding a putative acyl-HSL
• PMID 26092466

• Expression, purification and immobilization of recombinant AiiA enzyme onto magnetic nanoparticles.

• Beladiya C1, Tripathy RK1, Bajaj P1, Aggarwal G1, Pande AH2.
• Protein expression and purification.Protein Expr Purif.2015 Sep;113:56-62. doi: 10.1016/j.pep.2015.04.014. Epub 2015 May 14.
• AiiA is a "28-kDa lactonase" from Gram-positive Bacillus sp. 240B1. The enzyme can hydrolyze and inactivate a variety of acyl homoserine lactones (AHLs), quorum sensor molecules involve in bacterial quorum sensing (QS). AiiA is a strong candidate for the development of bio-decontaminating agent that
• PMID 25982248

• Involvement of quorum sensing genes in biofilm development and degradation of polycyclic aromatic hydrocarbons by a marine bacterium Pseudomonas aeruginosa N6P6.

• Mangwani N1, Kumari S, Das S.
• Applied microbiology and biotechnology.Appl Microbiol Biotechnol.2015 Aug 7. [Epub ahead of print]
• Biofilm-forming and acyl homoserine lactone (AHL) synthase-positive Pseudomonas aeruginosa N6P6 was isolated from seawater after selective enrichment with two polycyclic aromatic hydrocarbons (PAHs), viz. phenanthrene and pyrene. AHL synthesis was detected qualitatively using bioreporter strains. Th
• PMID 26245683

Japanese Journal

• Membrane vesicle-mediated bacterial communication

• The ISME journal 11(6), 1504-1509, 2017-06
• NAID 120006306132

• Identification and characterization of a novel N-acyl-homoserine lactonase gene in Sphingomonas ursincola isolated from industrial cooling water systems

• Journal of bioscience and bioengineering 123(5), 569-575, 2017-05
• NAID 40021205348

• Complete Genome Sequence of <i>Pseudomonas chlororaphis</i> subsp. <i>aurantiaca</i> Reveals a Triplicate Quorum-Sensing Mechanism for Regulation of Phenazine Production

• Ｍｉｃｒｏｂｅｓ　ａｎｄ　ｅｎｖｉｒｏｎｍｅｎｔｓ 32(1), 47-53, 2017
• NAID 130005519590

Related Links

• L-Homoserine | Sigma-Aldrich

Sigma-Aldrich offers Sigma-H6515, L-Homoserine for your research needs. Find product specific information including CAS, MSDS, protocols and references. ... Packaging 1, 5 g in poly bottle 10, 250 mg in poly bottle

• Showing metabocard for L-Homoserine (HMDB00719)

Record Information Version 3.6 Creation Date 2005-11-16 15:48:42 UTC Update Date 2016-02-11 01:03:16 UTC HMDB ID HMDB00719 Secondary Accession Numbers None Metabolite Identification Common Name L-Homoserine

Related Pictures

---

★リンクテーブル★

リンク元	「ホモセリン」
拡張検索	「aspartokinase homoserine dehydrogenase」「homoserine dehydrogenase」「homoserine O-succinyltransferase」

「ホモセリン」

　　[★]

英

homoserine

関

メチオニン

「aspartokinase homoserine dehydrogenase」

　　[★]

アスパルトキナーゼ・ホモセリン脱水素酵素、アスパルトキナーゼ・ホモセリンデヒドロゲナーゼ

「homoserine dehydrogenase」

　　[★]

ホモセリン脱水素酵素、ホモセリンデヒドロゲナーゼ

「homoserine O-succinyltransferase」

　　[★]

ホモセリン-O-サクシニルトランスフェラーゼ