アスパルトキナーゼ・ホモセリン脱水素酵素、アスパルトキナーゼ・ホモセリンデヒドロゲナーゼ
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- 1. ヘキソースリン酸側路およびグルタチオン代謝疾患（グルコース-6-リン酸脱水素酵素欠損症を除く）disorders of the hexose monophosphate shunt and glutathione metabolism other than glucose 6 phosphate dehydrogenase deficiency [show details]
…following. All are extremely rare with the exception of glucose-6-phosphate dehydrogenase deficiency. Glucose-6-phosphate dehydrogenase (G6PD) deficiency – The most common abnormality in this system is G6PD …
- 2. 乳酸脱水素酵素欠損症lactate dehydrogenase deficiency [show details]
…gluconeogenesis by the liver. The M isoform is a product of the lactate dehydrogenase A (LDHA) gene, located at 11p15 . The lactate dehydrogenase B (LDHB) gene that encodes the H isoform has been mapped to chromosome …
- 3. グルコース-6-リン酸脱水素酵素（G6PD）欠損症の遺伝学的特徴および病態生理genetics and pathophysiology of glucose 6 phosphate dehydrogenase g6pd deficiency [show details]
… Glucose-6-phosphate dehydrogenase (G6PD) deficiency, an X-linked disorder, is the most common enzymatic disorder of red blood cells in humans, affecting more than 400 million people worldwide . The clinical …
- 4. グルコース-6-リン酸脱水素酵素（G6PD）欠損症の診断とマネージメントdiagnosis and management of glucose 6 phosphate dehydrogenase g6pd deficiency [show details]
… Glucose-6-phosphate dehydrogenase (G6PD) deficiency is an inherited disorder caused by a genetic defect in the red blood cell (RBC) enzyme G6PD, which generates NADPH and protects RBCs from oxidative …
- 5. 特定の脂肪酸酸化障害specific fatty acid oxidation disorders [show details]
…long-chain acyl-coenzyme A dehydrogenase (VLCAD) Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase (LCHAD) Trifunctional protein (TFP) Medium-chain acyl-coenzyme A dehydrogenase (MCAD) Multiple acyl-coenzyme …
English Journal
- Integrating molecular dynamics and co-evolutionary analysis for reliable target prediction and deregulation of the allosteric inhibition of aspartokinase for amino acid production.
- Chen Z1, Rappert S, Sun J, Zeng AP.
- Journal of biotechnology.J Biotechnol.2011 Jul 20;154(4):248-54. doi: 10.1016/j.jbiotec.2011.05.005. Epub 2011 May 14.
- Deregulation of allosteric inhibition of enzymes is a challenge for strain engineering and has been achieved so far primarily by random mutation and trial-and-error. In this work, we used aspartokinase, an important allosteric enzyme for industrial amino acids production, to demonstrate a predictive
- PMID 21609739
- Systems-wide metabolic pathway engineering in Corynebacterium glutamicum for bio-based production of diaminopentane.
- Kind S1, Jeong WK, Schröder H, Wittmann C.
- Metabolic engineering.Metab Eng.2010 Jul;12(4):341-51. doi: 10.1016/j.ymben.2010.03.005. Epub 2010 Apr 8.
- In the present work the Gram-positive bacterium Corynebacterium glutamicum was engineered into an efficient, tailor-made production strain for diaminopentane (cadaverine), a highly attractive building block for bio-based polyamides. The engineering comprised expression of lysine decarboxylase (ldcC)
- PMID 20381632
- Homologous expression of aspartokinase (ask) gene in Streptomyces clavuligerus and its hom-deleted mutant: effects on cephamycin C production.
- Özcengiz G1, Okay S, Ünsaldı E, Taşkın B, Liras P, Piret J.
- Bioengineered bugs.Bioeng Bugs.2010 May-Jun;1(3):191-7. doi: 10.4161/bbug.1.3.11244. Epub 2010 Jan 11.
- In this study, the effect of homologous multiple copies of the ask gene, which encodes aspartokinase catalyzing the first step of the aspartate pathway, on cephamycin C biosynthesis in S. clavuligerus NRRL 3585 and its hom mutant was investigated. The intracellular pool levels of aspartate pathway a
- PMID 21326925
Japanese Journal
- Role of serine 352 in the allosteric response of Serratia marcescens aspartokinase I-homoserine dehydrogenase I analyzed by using site-directed mutagenesis.
- Nucleotide sequence of the Serratia marcescens threonine operon and analysis of the threonine operon mutations which alter feedback inhibition of both aspartokinase I and homoserine dehydrogenase I.
- The kinetic mechanisms of the bifunctional enzyme aspartokinase-homoserine dehydrogenase I from Excherichia coli.
Related Links
- Publications, Scientific Experts, Species, Research Topics, Research Grants, Genomes and Genes about aspartokinase homoserine dehydrogenase ... Summary: An enzyme complex consisting of aspartokinase, EC 2.7.2.4, and ...
- Aspartokinase Homoserine Dehydrogenase. On-line free medical diagnosis assistant. Ranked list of possible diseases from either several symptoms or a full patient history. A similarity measure between symptoms and diseases is ...
★リンクテーブル★
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- 英
- aspartokinase homoserine dehydrogenase
- 関
- アスパルトキナーゼ・ホモセリンデヒドロゲナーゼ
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- 英
- aspartokinase homoserine dehydrogenase
- 関
- アスパルトキナーゼ・ホモセリン脱水素酵素
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ホモセリン脱水素酵素、ホモセリンデヒドロゲナーゼ
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脱水素酵素 デヒドロゲナーゼ
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脱水素酵素 デヒドロゲナーゼ