ホモセリン-O-サクシニルトランスフェラーゼ
WordNet
- the 15th letter of the Roman alphabet (同)o
- the blood group whose red cells carry neither the A nor B antigens; "people with type O blood are universal donors" (同)type_O, group O
PrepTutorEJDIC
- 《呼び掛けの名前の前につけて》『おお』,あ / (驚き・恐れ・喜び・苦痛などを表して)『おお』,ああ,まあ / 《肯定・否定を強めて》
- oxygenの化学記号
- ohmオーム / Old
- osmiumの化学記号
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/07/10 01:14:30」(JST)
[Wiki en表示]
| homoserine O-succinyltransferase |
| Identifiers |
| EC number |
2.3.1.46 |
| CAS number |
62213-51-8 |
| Databases |
| IntEnz |
IntEnz view |
| BRENDA |
BRENDA entry |
| ExPASy |
NiceZyme view |
| KEGG |
KEGG entry |
| MetaCyc |
metabolic pathway |
| PRIAM |
profile |
| PDB structures |
RCSB PDB PDBe PDBsum |
| Gene Ontology |
AmiGO / EGO |
| Search |
| PMC |
articles |
| PubMed |
articles |
| NCBI |
proteins |
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In enzymology, a homoserine O-succinyltransferase (EC 2.3.1.46) is an enzyme that catalyzes the chemical reaction
- succinyl-CoA + L-homoserine CoA + O-succinyl-L-homoserine
Thus, the two substrates of this enzyme are succinyl-CoA and L-homoserine, whereas its two products are CoA and O-succinyl-L-homoserine.
This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups. The systematic name of this enzyme class is succinyl-CoA:L-homoserine O-succinyltransferase. Other names in common use include homoserine O-transsuccinylase, and homoserine succinyltransferase. This enzyme participates in methionine metabolism and sulfur metabolism.
Structural studies
As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 2GHR and 2H2W.
References
- Rowbury RJ; Woods DD (1964). "O-Succinylhomoserine as an intermediate in the synthesis of cystathionine by Escherichia coli". J. Gen. Microbiol. 36: 341–358. doi:10.1099/00221287-36-3-341. PMID 14217349.
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Transferases: acyltransferases (EC 2.3)
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| 2.3.1: other than amino-acyl groups |
- acetyltransferases: Acetyl-Coenzyme A acetyltransferase
- N-Acetylglutamate synthase
- Choline acetyltransferase
- Dihydrolipoyl transacetylase
- Acetyl-CoA C-acyltransferase
- Beta-galactoside transacetylase
- Chloramphenicol acetyltransferase
- N-acetyltransferase
- Serotonin N-acetyl transferase
- HGSNAT
- ARD1A
- Histone acetyltransferase
- palmitoyltransferases: Carnitine O-palmitoyltransferase
- Serine C-palmitoyltransferase
- other: Acyltransferase like 2
- Aminolevulinic acid synthase
- Beta-ketoacyl-ACP synthase
- Glyceronephosphate O-acyltransferase
- Lecithin—cholesterol acyltransferase
- Glycerol-3-phosphate O-acyltransferase
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- ABHD5
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| 2.3.2: Aminoacyltransferases |
- Gamma-glutamyl transpeptidase
- Peptidyl transferase
- Transglutaminase
- Tissue transglutaminase
- Keratinocyte transglutaminase
- Factor XIII
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| 2.3.3: converted into alkyl on transfer |
- Citrate synthase
- ATP citrate lyase
- HMG-CoA synthase
- Malate synthase
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Enzymes
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| Activity |
- Active site
- Binding site
- Catalytic triad
- Oxyanion hole
- Enzyme promiscuity
- Catalytically perfect enzyme
- Coenzyme
- Cofactor
- Enzyme catalysis
- Enzyme kinetics
- Lineweaver–Burk plot
- Michaelis–Menten kinetics
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| Regulation |
- Allosteric regulation
- Cooperativity
- Enzyme inhibitor
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| Classification |
- EC number
- Enzyme superfamily
- Enzyme family
- List of enzymes
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| Types |
- EC1 Oxidoreductases(list)
- EC2 Transferases(list)
- EC3 Hydrolases(list)
- EC4 Lyases(list)
- EC5 Isomerases(list)
- EC6 Ligases(list)
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UpToDate Contents
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- 1. 高IgD症候群：病態生理 hyperimmunoglobulin d syndrome pathophysiology
English Journal
- Identification of the potentiating mutations and synergistic epistasis that enabled the evolution of inter-species cooperation.
- Douglas SM1,2, Chubiz LM2,3, Harcombe WR2,4, Marx CJ2,5,6,7.
- PloS one.PLoS One.2017 May 11;12(5):e0174345. doi: 10.1371/journal.pone.0174345. eCollection 2017.
- PMID 28493869
- Metabolic engineering of Escherichia coli for microbial production of L-methionine.
- Huang JF1,2, Liu ZQ1,2, Jin LQ1,2, Tang XL1,2, Shen ZY1,2, Yin HH1,2, Zheng YG1,2.
- Biotechnology and bioengineering.Biotechnol Bioeng.2017 Apr;114(4):843-851. doi: 10.1002/bit.26198. Epub 2016 Oct 21.
- PMID 27723097
- Stabilization of homoserine-O-succinyltransferase (MetA) decreases the frequency of persisters in Escherichia coli under stressful conditions.
- Mordukhova EA1, Pan JG1.
- PloS one.PLoS One.2014 Oct 17;9(10):e110504. doi: 10.1371/journal.pone.0110504. eCollection 2014.
- PMID 25329174
Related Links
- Homoserine O-succinyltransferase (EC:2.3.1.46) Alternative name(s): Homoserine O-transsuccinylase Short name: HTS Gene names i Name ...
- Subunit composition of homoserine O-succinyltransferase = [MetA] 2 homoserine O-succinyltransferase = MetA Summary: Homoserine O-succinyltransferase (MetA) catalyzes the first unique step in the de novo methionine biosynthesis pathway in ...
★リンクテーブル★
[★]
- 英
- homoserine O-succinyltransferase
[★]
- 同
- 食道入口部
[★]
オスミウム osmium