ヘテロ核リボヌクレオタンパク質K
- 関
- hnRNP K
WordNet
- of or relating to or constituting the nucleus of an atom; "nuclear physics"; "nuclear fission"; "nuclear forces"
- (weapons) deriving destructive energy from the release of atomic energy; "nuclear war"; "nuclear weapons"; "atomic bombs" (同)atomic
- constituting or like a nucleus; "annexation of the suburban fringe by the nuclear metropolis"; "the nuclear core of the congregation"
- of or relating to or constituting the nucleus of a cell; "nuclear membrane"; "nuclear division"
- consisting of elements that are not of the same kind or nature; "the population of the United States is vast and heterogeneous" (同)heterogenous
- United States guitar player and singer of the blues (born in 1925) (同)B. B. King, Riley B King
- United States woman tennis player (born in 1943) (同)Billie Jean King, Billie Jean Moffitt King
- United States charismatic civil rights leader and Baptist minister who campaigned against the segregation of Blacks (1929-1968) (同)Martin Luther King, Martin Luther King Jr.
- street names for ketamine (同)jet, super acid, special K, honey oil, green, cat valium, super C
- the 11th letter of the Roman alphabet (同)k
PrepTutorEJDIC
- 『核の』,細胞核の / [『原子』]『核の』
- 異種の,異質の / 異成分から成る,不均質の
- Kelvin / Kindergarten / (チェスの)King / kalium(ラテン語)(=potassium)の化学記号
UpToDate Contents
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English Journal
- S100A7 overexpression is a predictive marker for high risk of malignant transformation in oral dysplasia.
- Kaur J, Matta A, Kak I, Srivastava G, Assi J, Leong I, Witterick I, Colgan TJ, Macmillan C, Siu KW, Walfish PG, Ralhan R.Author information Alex and Simona Shnaider Laboratory in Molecular Oncology, Mount Sinai Hospital, Joseph & Wolf Lebovic Health Complex, Toronto, ON, Canada.AbstractEarly detection of oral lesions (OLs) at high risk of cancer development is of utmost importance for intervention. There is an urgent unmet clinical need for biomarkers that allow identification of high-risk OLs. Recently, we identified and verified a panel of five candidate protein biomarkers namely S100A7, prothymosin alpha, 14-3-3ζ, 14-3-3σ and heterogeneous nuclear ribonucleoprotein K using proteomics to distinguish OLs with dysplasia and oral cancers from normal oral tissues. The objective of our study was to evaluate the potential of these candidate protein biomarkers for identification of oral dysplastic lesions at high risk of cancer development. Using immunohistochemistry, we analyzed expressions of these five candidate protein biomarkers in 110 patients with biopsy-proven oral dysplasia and known clinical outcome and determined their correlations with p16 expression and HPV 16/18 status. Kaplan-Meier survival analysis showed reduced oral cancer-free survival (OCFS) of 68.6 months (p = 0.007) in patients showing cytoplasmic S100A7 overexpression when compared to patients with weak or no S100A7 immunostaining in cytoplasm (mean OCFS = 122.8 months). Multivariate Cox regression analysis revealed cytoplasmic S100A7 overexpression as the most significant candidate marker associated with cancer development in dysplastic lesions (p = 0.041, hazard ratio = 2.36). In conclusion, our study suggested the potential of S100A7 overexpression in identifying OLs with dysplasia at high risk of cancer development.
- International journal of cancer. Journal international du cancer.Int J Cancer.2014 Mar 15;134(6):1379-88. doi: 10.1002/ijc.28473. Epub 2013 Oct 8.
- Early detection of oral lesions (OLs) at high risk of cancer development is of utmost importance for intervention. There is an urgent unmet clinical need for biomarkers that allow identification of high-risk OLs. Recently, we identified and verified a panel of five candidate protein biomarkers namel
- PMID 24122701
- Long noncoding RNAs: Novel insights into hepatocelluar carcinoma.
- He Y1, Meng XM1, Huang C1, Wu BM1, Zhang L1, Lv XW1, Li J2.Author information 1School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China.2School of Pharmacy, Anhui Key Laboratory of Bioactivity of Natural Products, Anhui Medical University, Hefei 230032, China; The Key Laboratory of Anti-Inflammatory and Immune Medicine (Anhui Medical University), Ministry of Education, China; Institute for Liver Diseases of Anhui Medical University (ILD-AMU), Anhui Medical University, Hefei 230032, China. Electronic address: heyongR99@163.com.AbstractRecent advances in non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack of coding protein function, termed long noncoding RNAs (lncRNAs). It is becoming evident that lncRNAs may be an important class of pervasive genes involved in carcinogenesis and metastasis. However, the biological and molecular mechanisms of lncRNAs in diverse diseases are not yet fully understood. Thus, it is anticipated that more efforts should be made to clarify the lncRNAs world. Moreover, accumulating studies have demonstrated that a class of lncRNAs are dysregulated in hepatocellular carcinoma(HCC) and closely related with tumorigenesis, metastasis, prognosis or diagnosis. In this review, we will briefly discuss the regulation and functional role of lncRNAs in HCC, therefore evaluating the potential of lncRNAs as prospective novel therapeutic targets in HCC.
- Cancer letters.Cancer Lett.2014 Mar 1;344(1):20-7. doi: 10.1016/j.canlet.2013.10.021. Epub 2013 Oct 30.
- Recent advances in non-protein coding part of human genome analysis have discovered extensive transcription of large RNA transcripts that lack of coding protein function, termed long noncoding RNAs (lncRNAs). It is becoming evident that lncRNAs may be an important class of pervasive genes involved i
- PMID 24183851
- A Human Proteome Microarray Identifies that the Heterogeneous Nuclear Ribonucleoprotein K (hnRNP K) Recognizes the 5' Terminal Sequence of the Hepatitis C Virus RNA.
- Fan B, Lu KY, Reymond Sutandy FX, Chen YW, Konan K, Zhu H, Kao CC, Chen CS.Author information Department of Molecular and Cellular Biochemistry, Indiana University, Bloomington, Indiana 47405;AbstractStem-loop I (SL1) located in the 5' untranslated region of the hepatitis C virus (HCV) genome initiates binding to miR-122, a microRNA required for hepatitis HCV replication. However, proteins that bind SL1 remain elusive. In this study, we employed a human proteome microarray, comprised of ∼17,000 individually purified human proteins in full-length, and identified 313 proteins that recognize HCV SL1. Eighty-three of the identified proteins were annotated as liver-expressing proteins, and twelve of which were known to be associated with hepatitis virus. siRNA-induced silencing of eight out of 12 candidate genes led to at least 25% decrease in HCV replication efficiency. In particular, knockdown of heterogeneous nuclear ribonucleoprotein K (hnRNP K) reduced HCV replication in a concentration-dependent manner. Ultra-violet-crosslinking assay also showed that hnRNP K, which functions in pre-mRNA processing and transport, showed the strongest binding to the HCV SL1. We observed that hnRNP K, a nuclear protein, is relocated in the cytoplasm in HCV-expressing cells. Immunoprecipitation of the hnRNP K from Huh7.5 cells stably expressing HCV replicon resulted in the co-immunoprecipitation of SL1. This work identifies a cellular protein that could have an important role in the regulation of HCV RNA gene expression and metabolism.
- Molecular & cellular proteomics : MCP.Mol Cell Proteomics.2014 Jan;13(1):84-92. doi: 10.1074/mcp.M113.031682. Epub 2013 Oct 10.
- Stem-loop I (SL1) located in the 5' untranslated region of the hepatitis C virus (HCV) genome initiates binding to miR-122, a microRNA required for hepatitis HCV replication. However, proteins that bind SL1 remain elusive. In this study, we employed a human proteome microarray, comprised of ∼17,00
- PMID 24113282
Japanese Journal
- An X-chromosome RNA-binding motif protein (RBMX) is required for proper kinetochore formation
- LEE Mei Hann,LIN Linyen,TAKATA Hideaki,MORIMOTO Akihiro,UCHIYAMA Susumu,MATSUNAGA Sachihiro,FUKUI Kiichi
- Chromosome science 14(1), 17-21, 2012-03-01
- RBMX is an RNA-binding motif protein identified as a component of purified human metaphase chromosomes. We have analyzed the functional significance of RBMX by electron microscopy (EM) in combination …
- NAID 10030317380
- 二次元Phos-tag親和性電気泳動 (特集 リン酸化生体分子解析のためのフォスタグテクノロジー)
- 木村 弥生,永田 佳代子,平野 久 [他]
- 生物物理化学 = Journal of electrophoresis 56(-) (Sppl.1), s21-24, 2012-01
- NAID 40019214161
- リン酸化アフィニティー二次元電気泳動を用いた Heterogeneous nuclear ribonucleoprotein K の質的・量的変動モニタリング
- 木村 弥生,永田 佳代子,鈴木 信勇,横山 亮,山中 結子,平野 久,北村 浩,小原 收
- 生物物理化學 53(3), 77, 2009-08-10
- NAID 10025708102
Related Links
- This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA).
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★リンクテーブル★
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- 関
- heterogeneous-nuclear ribonucleoprotein K
[★]
- 英
- heterogeneous-nuclear ribonucleoprotein K、hnRNP K
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- 不均一な、不均一性の、異種性の、異種起源の、異質な
- 関
- alien、foreign、hetero、heterogeneity、heterogeneously、heterogenous、heterogenously、heterologous、heterologously、nonuniform、nonuniformity、ununiform、ununiformity、ununiformly
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- 関
- cell nuclei、cell nucleus、nuclei、nucleo、nucleus
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リボ核タンパク質、リボヌクレオタンパク質、リボ核タンパク、RNAタンパク質
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[★]
- 関
- binding dissociation constant、dissociation constant