herpangina

ヘルパンギーナ

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/10/09 15:32:53」(JST)

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Herpangina
Classification and external resources
ICD-10	B08.5
ICD-9	074.0
DiseasesDB	30777
MedlinePlus	000969
eMedicine	med/1004 article/218502 MeshID = D006557

Herpangina, also called mouth blisters, is the name of a painful mouth infection caused by coxsackieviruses. Usually, herpangina is produced by one particular strain of coxsackie virus A (and the term "herpangina virus" refers to coxsackievirus A) but it can also be caused by coxsackievirus B or echoviruses. Most cases of herpangina occur in the summer, affecting mostly children. However, it occasionally occurs in adolescents and adults. It was first characterized in 1920.

Presentation

Though herpangina can be asymptomatic, symptoms usually associated are high fever and sore throat.

A small number of lesions (usually 2 - 6) form in the back area of the mouth, particularly the soft palate or tonsillar pillars. The lesions progress initially from red macules to vesicles and lastly to ulcerations which can be 2 – 4 mm in size. The lesions heal in 7 – 10 days.

Histologically, the epithelial cells show signs of intracellular and extracellular edema.

Etymology

The term is derived from the Greek herp, creeping, snake like, and Latin angina, a sore throat, literally "a choking."

Clinical features

• Most commonly affects infants and young children
• Typically occurs during the summer
• Typically spreads via the fecal-oral route or via the respiratory droplets.
• Fatigue will last about three to four days after treatment.

Symptoms

Symptoms include sudden fever with sore throat, headache, loss of appetite, and often neck pain. Within two days of onset an average of four or five (but sometimes up to twenty) 1 to 2 mm diameter grayish lumps form and develop into vesicles with red surrounds, and over 24 hours these become shallow ulcers, rarely larger than 5 mm diameter, that heal in one to seven days. These lesions most often appear on the tonsillar pillars (adjacent to the tonsils), but also on the soft palate, tonsils, uvula, or tongue.

A diagnosis can be made from clinical signs and symptoms, and treatment consists of minimizing the discomfort of symptoms.

Treatment

Treatment is usually supportive only, as the disease is self-limiting and usually runs its course in less than a week.

Drinking cold beverages, especially milk and eating ice cream are recommended. Hot and high acidity beverages are to be avoided.

No Antiviral medications exist for Coxsackie A or other Enteroviruses.

See also

• List of cutaneous conditions

References

External links

• Herpangina

UpToDate Contents

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• 1. 手足口病およびヘルパンギーナ：概要 hand foot and mouth disease and herpangina an overview
• 2. エンテロウイルスおよびパレコウイルス感染の臨床症状および診断 clinical manifestations and diagnosis of enterovirus and parechovirus infections
• 3. 小児における口腔軟部組織病変 soft tissue lesions of the oral cavity in children
• 4. 若齢小児におけるヘルペス性歯肉口内炎 herpetic gingivostomatitis in young children
• 5. 小児における咽喉痛の評価 evaluation of sore throat in children

English Journal

• Genetic characterization of human coxsackievirus A6 variants associated with atypical hand, foot and mouth disease: a potential role of recombination in emergence and pathogenicity.

• Gaunt E1, Harvala H2, Österback R3, Sreenu VB4, Thomson E4, Waris M3, Simmonds P5.
• The Journal of general virology.J Gen Virol.2015 May;96(Pt 5):1067-79. doi: 10.1099/vir.0.000062. Epub 2015 Jan 22.
• Human coxsackievirus A6 (CVA6) is an enterically transmitted enterovirus. Until recently, CVA6 infections were considered as being of minor clinical significance, and only rarely aetiologically linked with hand, foot and mouth disease (HFMD) associated with other species A enteroviruses (particularl
• PMID 25614593

• Epidemiology of childhood enterovirus infections in Hangzhou, China.

• Li W1, Zhang X2, Chen X3, Cheng YP4, Wu YD5, Shu Q6, Chen XJ7, Shang SQ8.
• Virology journal.Virol J.2015 Apr 14;12(1):58. [Epub ahead of print]
• BACKGROUND: There are over 100 serotypes of enterovirus species A-D, which are the common cause of various symptoms in infants, such as meningitis, encephalitis and hand foot mouth disease (HFMD). This study aims to investigate the epidemiological characteristics of enteroviruses in Hangzhou, Zhejia
• PMID 25884568

• Proteomics analysis of EV71-infected cells reveals the involvement of host protein NEDD4L in EV71 replication.

• Kuo RL1,2, Lin YH1,2, Wang RY2,3, Hsu CW4, Chiu YT1, Huang HI1,2, Kao LT1,2, Yu JS4, Shih SR1,2,5, Wu CC1,4.
• Journal of proteome research.J Proteome Res.2015 Apr 3;14(4):1818-30. doi: 10.1021/pr501199h. Epub 2015 Mar 26.
• Enterovirus 71 (EV71) is a human enterovirus that has seriously affected the Asia-Pacific area for the past two decades. EV71 infection can result in mild hand-foot-and-mouth disease and herpangina and may occasionally lead to severe neurological complications in children. However, the specific biol
• PMID 25785312

Japanese Journal

• 手足口病,ヘルパンギーナ患者の発生動向およびウイルスの検出動向に関する解析

• 神奈川県衛生研究所研究報告 (46), 22-26, 2016-09
• NAID 40020989452

• 大阪府におけるエンテロウイルスおよびヒトパレコウイルス感染症の流行状況と分子疫学的解析(2014 年度)

• 大阪府立公衆衛生研究所研究報告=Bulletin of Osaka Prefectural Institute of Pubkic Health 53, 7-14, 2015-10
• NAID 110010040251

• 大阪府におけるエンテロウイルス感染症の流行状況と分子疫学的解析(2013 年度)

• 大阪府立公衆衛生研究所研究報告=Bulletin of Osaka Prefectural Institute of Pubkic Health 52, 7-14, 2014-10
• NAID 110010040218

Related Pictures

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★リンクテーブル★

リンク元	「ヘルパンギーナ」「疱疹性口峡炎」

「ヘルパンギーナ」

　　[★]

herp (水疱の) + angina (口峡炎)

英

herpangina

同

ヘルパンギナ、水疱性口峡炎、疱疹性アンギナ、疱疹性口峡炎

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ヘルパンギーナ　 : 約 307,000 件
ヘルパンギナ : 約 691 件
水疱性口峡炎 : 44 件

概念

• エンテロウイルスの感染症。扁桃や軟口蓋に水疱性の粘膜疹を呈し、主に3-10歳で感染が見られる。咽頭の症状が殆どで、嚥下時や発熱を伴う。多くの場合夏場にoutbreakする。

• 病原体としてコクサッキーウイルスA群(group A coxsackieviruses)がある。

疫学

• 4歳以下が多く、特に1歳に多い。

病原体

• エンテロウイルス属(コクサッキーウイルスA群2,4,5,6,8,10) (IRE.765)

潜伏期

• 2-4日ないし2-7日

症状

• 発熱、哺乳低下、流涎、咽頭痛、嚥下困難

身体所見

• 口腔内：灰白色の丘疹と水疱が扁桃腺の前部、軟口蓋、口蓋に認められる。 (IRE.765)

経過

• 4-5日の経過で消失

参考

• 1. [charged] 小児における口腔軟部組織病変 - uptodate [1]
• 2. [charged] エンテロウイルスとパラエコーウイルス感染症の臨床症状と診断 - uptodate [2]

「疱疹性口峡炎」

　　[★]

英

herpangina

関

ヘルパンギナ