English Journal

Multinational, double-blind, randomised, placebo-controlled, prospective study of esomeprazole in the prevention of recurrent peptic ulcer in low-dose acetylsalicylic acid users: the LAVENDER study.

Sugano K1, Choi MG2, Lin JT3, Goto S4, Okada Y5, Kinoshita Y6, Miwa H7, Chiang CE8, Chiba T9, Hori M10, Fukushima Y11, Kim HS12, Chang CY13, Date M14; LAVENDER Study Group.
Gut.Gut.2014 Jul;63(7):1061-8. doi: 10.1136/gutjnl-2013-304722. Epub 2013 Dec 10.
OBJECTIVES: To evaluate if esomeprazole prevents recurrent peptic ulcer in adult patients with a history of peptic ulcer receiving low-dose acetylsalicylic acid (ASA, aspirin) for cardiovascular protection in East Asia.METHODS: In this prospective, randomised, double-blind, placebo-controlled trial
PMID 24326741

Substrate specificity of undecaprenyl diphosphate synthase from the hyperthermophilic archaeon Aeropyrum pernix.

Mori T1, Ogawa T, Yoshimura T, Hemmi H.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Jun 28;436(2):230-4. doi: 10.1016/j.bbrc.2013.05.081. Epub 2013 May 31.
Cis-prenyltransferase from a hyperthermophilic archaeon Aeropyrum pernix was expressed in Escherichia coli and purified for characterization. Properties such as substrate specificity, product chain-length, thermal stability and cofactor requirement were investigated using the recombinant enzyme. In
PMID 23726912

Endoscopic evaluation of low-dose aspirin-induced gastric and duodenal ulcers during prophylaxis with lansoprazole.

Sakaki N, Ashida K, Mizokami Y, Chiba T, Matsui S, Kanto T, Uemura N, Hiramatsu N, Sugano K.
Hepato-gastroenterology.Hepatogastroenterology.2013 Jun;60(124):762-7. doi: 10.5754/hge12920. Epub 2013 Mar 11.
BACKGROUND/AIMS: To compare the endoscopic features of LDA-induced ulcers developing during secondary prophylaxis with lansoprazole (LPZ) and gefarnate (GFN).METHODOLOGY: All ulcers that had developed during prophylaxis with LPZ (15mg once daily) and GFN (50mg twice daily) in a prospective, randomiz
PMID 23478070

Japanese Journal

Effect of Gefarnate on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator, in Comparison with That of Teprenone(Pharmacology)

リンク元