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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2019/01/08 17:31:25」(JST)

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Gefarnate is a drug used for the treatment of gastric ulcers.^[1]

It also has been proposed for use in the treatment of dry eye syndrome.^[2]^[3]

References

^ Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S (August 2005). "Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone". Biol. Pharm. Bull. 28 (8): 1424–30. doi:10.1248/bpb.28.1424. PMID 16079487.
^ Peral A, Domínguez-Godínez CO, Carracedo G, Pintor J (April 2008). "Therapeutic targets in dry eye syndrome". Drug News Perspect. 21 (3): 166–76. PMID 18560615.
^ Gipson IK, Hori Y, Argüeso P (April 2004). "Character of ocular surface mucins and their alteration in dry eye disease". Ocul Surf. 2 (2): 131–48. doi:10.1016/s1542-0124(12)70149-0. PMID 17216084.^{[permanent dead link]}

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UpToDate Contents

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1. シェーグレン症候群におけるドライアイの治療 treatment of dry eye in sjogrens syndrome

English Journal

Further Insight into Polycyclization Cascades of Acyclic Geranylfarnesol and its Acetate by Squalene-hopene Cyclase from Alicyclobacillus acidocaldarius.

Cheng J, Nakano C, Shi GL, Hoshino T.
Natural product communications.Nat Prod Commun.2016 Feb;11(2):163-7.
The enzymatic reactions of geranylfarnesol (8) and its acetate 9, classified as sesterterpenes (C25), using squalene-hopene cyclase (SHC) were investigated. The enzymatic reaction of 8 afforded 6/6-fused bicyclic 20, 6/6/6-fused tricyclic 21, and 6/6/6/6-fused tetracyclic compounds 22 and 23 as the
PMID 27032191

Multinational, double-blind, randomised, placebo-controlled, prospective study of esomeprazole in the prevention of recurrent peptic ulcer in low-dose acetylsalicylic acid users: the LAVENDER study.

Sugano K1, Choi MG2, Lin JT3, Goto S4, Okada Y5, Kinoshita Y6, Miwa H7, Chiang CE8, Chiba T9, Hori M10, Fukushima Y11, Kim HS12, Chang CY13, Date M14; LAVENDER Study Group.
Gut.Gut.2014 Jul;63(7):1061-8. doi: 10.1136/gutjnl-2013-304722. Epub 2013 Dec 10.
PMID 24326741

Substrate specificity of undecaprenyl diphosphate synthase from the hyperthermophilic archaeon Aeropyrum pernix.

Mori T1, Ogawa T, Yoshimura T, Hemmi H.
Biochemical and biophysical research communications.Biochem Biophys Res Commun.2013 Jun 28;436(2):230-4. doi: 10.1016/j.bbrc.2013.05.081. Epub 2013 May 31.
PMID 23726912

Japanese Journal

内服薬剤の懸濁液によるポリスチレン製器具の溶解現象:-薬剤の懸濁に用いる器具の材質への注意-

医療薬学 36(5), 310-315, 2010
NAID 130004502598

Compound 48/80 惹起急性胃粘膜傷害の進展に対するゲファルナートの抑制効果

潰瘍 = Ulcer research 32(2), 198-201, 2005-11-09
NAID 10016832876

Effect of Gefarnate on Acute Gastric Mucosal Lesion Progression in Rats Treated with Compound 48/80, a Mast Cell Degranulator, in Comparison with That of Teprenone(Pharmacology)

Biological & pharmaceutical bulletin 28(8), 1424-1430, 2005-08-01
NAID 10016666758

Related Pictures

－藥品資訊 Anti ulcer How to Make Cabbage Juice for Ulcers - Health Ambition 潘妥洛克(泮托拉唑肠溶片)说明书,潘妥洛克(泮托拉唑肠溶片)副 GEFARNATE 相關藥品一覽 @ 藥要看 File:Zantac.jpg - Wikimedia Commons 冠心病合并心房颤动患者治疗策略选择_经典病例_医脉通吉法酯杂质 Gefarnate Impurity 对照品标准品_深圳远扬医药科技有限公司

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「ゲファルナート」

Gefarnate
Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	A02BX07 (WHO) ;
Identifiers
	IUPAC name (2E)-3,7-dimethylocta-2,6-dien-1-yl (4E,8E)-5,9,13-trimethyltetradeca-4,8,12-trienoate;
CAS Number	51-77-4 ;
PubChem CID	5282182;
ChemSpider	4445377 ;
UNII	1ISE2Y6ULA;
KEGG	D01529 ;
ChEMBL	ChEMBL2105085 ;
ECHA InfoCard	100.000.111
Chemical and physical data
Formula	C27H44O2
Molar mass	400.637 g/mol
3D model (JSmol)	Interactive image;
	SMILES CC(C)=CCC/C(C)=C/CC/C(C)=C/CCC(=O)OC/C=C(C)/CCC=C(C)C;
	InChI InChI=1S/C27H44O2/c1-22(2)12-8-14-24(5)16-10-17-25(6)18-11-19-27(28)29-21-20-26(7)15-9-13-23(3)4/h12-13,16,18,20H,8-11,14-15,17,19,21H2,1-7H3/b24-16+,25-18+,26-20+ ; Key:ZPACYDRSPFRDHO-ROBAGEODSA-N ;
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　　[★]

英: gefarnate
化: ゲラニルファルネシルアセテート geranyl farnesylacetate
商: エラシオン、ゲファルト、ゲファニール、サラニール、ヨウファナート
関: 消化性潰瘍用剤

[pmid16079487-1] Ohta Y, Kobayashi T, Imai Y, Inui K, Yoshino J, Nakazawa S (August 2005). "Effect of gefarnate on acute gastric mucosal lesion progression in rats treated with compound 48/80, a mast cell degranulator, in comparison with that of teprenone". Biol. Pharm. Bull. 28 (8): 1424–30. doi:10.1248/bpb.28.1424. PMID 16079487.

[pmid18560615-2] Peral A, Domínguez-Godínez CO, Carracedo G, Pintor J (April 2008). "Therapeutic targets in dry eye syndrome". Drug News Perspect. 21 (3): 166–76. PMID 18560615.

[pmid17216084-3] Gipson IK, Hori Y, Argüeso P (April 2004). "Character of ocular surface mucins and their alteration in dry eye disease". Ocul Surf. 2 (2): 131–48. doi:10.1016/s1542-0124(12)70149-0. PMID 17216084.^{[permanent dead link]}

v t e Drugs for peptic ulcer and GERD/GORD (A02B)
H₂ antagonists ("-tidine")	Cimetidine Famotidine Lafutidine Lavoltidine (loxtidine) Niperotidine Nizatidine Ranitidine^# Roxatidine
Prostaglandins (E)/analogues ("-prost-")	Misoprostol Enprostil
Proton-pump inhibitors ("-prazole")	Azeloprazole Dexlansoprazole Esomeprazole Ilaprazole Lansoprazole Omeprazole^# Pantoprazole Picoprazole Rabeprazole Tenatoprazole Timoprazole
Potassium-competitive acid blockers ("-prazan")	Linaprazan Revaprazan Soraprazan Vonoprazan
Others	Aceglutamide aluminum Acetoxolone Alginic acid Arbaclofen placarbil Bismuth subcitrate Carbenoxolone Cetraxate Gefarnate Lesogaberan Pirenzepine Proglumide Rebamipide Sucralfate Sulglicotide Telenzepine Teprenone Troxipide Zinc L-carnosine Zolimidine
Combinations	Bismuth subcitrate/metronidazole/tetracycline
See also: Helicobacter pylori* eradication protocols*
^#WHO-EM ^‡Withdrawn from market Clinical trials: ^†Phase III ^§Never to phase III

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gefarnate