WordNet
- pertaining to or referring to origin; "genetic history reconstructs the origins of a literary work"
- of or relating to the science of genetics; "genetic research" (同)genetical
- the branch of biology that studies heredity and variation in organisms (同)genetic science
- agile Old World viverrine having a spotted coat and long ringed tail (同)Genetta genetta
PrepTutorEJDIC
- 遺伝学
- phenomenonの複数形
UpToDate Contents
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- 1. メンデル遺伝の概要 overview of mendelian inheritance
- 2. 遺伝性疾患の基本原則 basic principles of genetic disease
- 3. 遺伝カウンセリングおよび遺伝子検査 genetic counseling and testing
- 4. 遺伝子検査における偶発的所見 incidental findings from genetic testing
- 5. 遺伝性乳癌・卵巣癌症候群の遺伝カウンセリングおよび遺伝子検査 genetic counseling and testing for hereditary breast and ovarian cancer
English Journal
- The role of mitochondrial electron transport in tumorigenesis and metastasis.
- Tan AS1, Baty JW1, Berridge MV2.Author information 1Malaghan Institute of Medical Research, PO Box 7060, Wellington 6242, New Zealand.2Malaghan Institute of Medical Research, PO Box 7060, Wellington 6242, New Zealand. Electronic address: mberridge@malaghan.org.nz.AbstractBACKGROUND: Tumor formation and spread via the circulatory and lymphatic drainage systems is associated with metabolic reprogramming that often includes increased glycolytic metabolism relative to mitochondrial energy production. However, cells within a tumor are not identical due to genetic change, clonal evolution and layers of epigenetic reprogramming. In addition, cell hierarchy impinges on metabolic status while tumor cell phenotype and metabolic status will be influenced by the local microenvironment including stromal cells, developing blood and lymphatic vessels and innate and adaptive immune cells. Mitochondrial mutations and changes in mitochondrial electron transport contribute to metabolic remodeling in cancer in ways that are poorly understood.
- Biochimica et biophysica acta.Biochim Biophys Acta.2014 Apr;1840(4):1454-1463. doi: 10.1016/j.bbagen.2013.10.016. Epub 2013 Oct 17.
- BACKGROUND: Tumor formation and spread via the circulatory and lymphatic drainage systems is associated with metabolic reprogramming that often includes increased glycolytic metabolism relative to mitochondrial energy production. However, cells within a tumor are not identical due to genetic change,
- PMID 24141138
- (Pro)renin receptor and V-ATPase: from Drosophila to humans.
- Rousselle A1, Sihn G1, Rotteveel M1, Bader M.Author information 1*Max-Delbrück-Center for Molecular Medicine (MDC), Robert-Rössle-Str. 10, D-13125 Berlin-Buch, Germany.AbstractA decade ago, the (P)RR [(pro)renin receptor] was discovered and depicted as a potential activator of the tissue renin-angiotensin system. For this reason, the role of the (P)RR in cardiovascular diseases and diabetes has been particularly studied. However, the discovery of embryonic lethality after (P)RR gene deletion in mouse and zebrafish paved the way for additional roles of (P)RR in cell homoeostasis. Indeed, the (P)RR has been shown to associate with vacuolar H+-ATPase, hence its other name ATP6ap2. Developmental studies in Xenopus and Drosophila have revealed an essential role of this association to promote the canonical and non-canonical Wnt signalling pathways, whereas studies with tissue-specific gene deletion have pointed out a role in autophagy. The present review aims to summarize recent findings on the cellular functions of (P)RR emerging from various mutated and transgenic animal models.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Apr;126(8):529-36. doi: 10.1042/CS20130307.
- A decade ago, the (P)RR [(pro)renin receptor] was discovered and depicted as a potential activator of the tissue renin-angiotensin system. For this reason, the role of the (P)RR in cardiovascular diseases and diabetes has been particularly studied. However, the discovery of embryonic lethality after
- PMID 24400720
- Muscle disuse atrophy is not accompanied by changes in skeletal muscle satellite cell content.
- Snijders T1, Wall BT1, Dirks ML1, Senden JM1, Hartgens F2, Dolmans J3, Losen M4, Verdijk LB1, van Loon LJ1.Author information 1*Department of Human Movement Sciences, School for Nutrition, Toxicology and Metabolism (NUTRIM), Maastricht University, Maastricht, The Netherlands.2†Departments of Epidemiology and Surgery, School for Public Health and Primary Care (CAPHRI), Maastricht University Medical Centre+, Maastricht, The Netherlands.3‡Department of Surgery, Maastricht University Medical Centre+, Maastricht, The Netherlands.4§Department of Neuroscience, School of Mental Health and Neuroscience, Maastricht University, Maastricht, The Netherlands.AbstractMuscle disuse leads to a considerable loss in skeletal muscle mass and strength. However, the cellular mechanisms underlying disuse-induced muscle fibre atrophy remain to be elucidated. Therefore we assessed the effect of muscle disuse on the CSA (cross-sectional area), muscle fibre size, satellite cell content and associated myocellular signalling pathways of the quadriceps muscle. A total of 12 healthy young (24±1 years of age) men were subjected to 2 weeks of one-legged knee immobilization via a full-leg cast. Before and immediately after the immobilization period and after 6 weeks of natural rehabilitation, muscle strength [1RM (one-repetition maximum)], muscle CSA [single slice CT (computed tomography) scan] and muscle fibre type characteristics (muscle biopsies) were assessed. Protein and/or mRNA expression of key genes [i.e. MYOD (myogenic differentiation), MYOG (myogenin) and MSTN (myostatin)] in the satellite cell regulatory pathways were determined using Western blotting and RT-PCR (real-time PCR) analyses respectively. The present study found that quadriceps CSA declined following immobilization by 8±2% (P<0.05). In agreement, both type I and type II muscle fibre size decreased 7±3% and 13±4% respectively (P<0.05). No changes were observed in satellite cell content following immobilization in either type I or type II muscle fibres. Muscle MYOG mRNA expression doubled (P<0.05), whereas MSTN protein expression decreased 30±9% (P<0.05) following immobilization. Muscle mass and strength returned to the baseline values within 6 weeks of recovery without any specific rehabilitative programme. In conclusion, 2 weeks of muscle disuse leads to considerable loss in skeletal muscle mass and strength. The loss in muscle mass was attributed to both type I and type II muscle fibre atrophy, and was not accompanied by a decline in satellite cell content.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Apr;126(8):557-66. doi: 10.1042/CS20130295.
- Muscle disuse leads to a considerable loss in skeletal muscle mass and strength. However, the cellular mechanisms underlying disuse-induced muscle fibre atrophy remain to be elucidated. Therefore we assessed the effect of muscle disuse on the CSA (cross-sectional area), muscle fibre size, satellite
- PMID 24215591
Japanese Journal
- 代謝を生きる : 移動性をめぐる実験的考察(<特集>身体のハイブリッド)
- モハーチ ゲルゲイ
- 文化人類学 76(3), 288-307, 2011-12-31
- 今日の日本において病気そのものの民族誌を描き出すことを目的とするならば、遅かれ早かれ、科学の現場にたどり着くことになるだろう。本論文では、種々の民族誌的ならびに科学的な材料をもとに、医学の二つの現場である臨床と研究所で行われるさまざまな実践を描く試みを展開し、そこで生活習慣と倹約遺伝子という、糖尿病学のそれぞれ異なる標的を行き来する代謝の動きを追いかけていく。糖尿病などの慢性病を患っている多くの人 …
- NAID 110008897504
- シンポジウム「統合医科学研究所(TIIMS)の紹介と今後の展望」(3)遺伝子機能解析から疾患解析へ
- 三谷 昌平
- 東京女子医科大学雑誌 81(3), 204-209, 2011-06-25
- 疾患の発症には遺伝要因が関与することが多いし、環境要因も、生体の生理機能の理解なしには解明できない。我々は、主として線虫と培養細胞を用いて遺伝子機能解析を行っている。線虫には約20,000の遺伝子が存在しており、ヒトゲノム解読に先立って解読が行われた。形態が全く異なるにも関わらず、約6割の遺伝子は、ヒトなどの他の生物のホモログであると考えられており、既知の疾患遺伝子のホモログも多数存在する。ヒトな …
- NAID 110008585265
Related Links
- Definition of genetic phenomena in the Definitions.net dictionary. Meaning of genetic phenomena. What does genetic phenomena mean? Information and translations of genetic phenomena in the most comprehensive dictionary ...
- Another theory says that people went out into the woods and deliberately trapped wolf pups, with the goal of training them to be sentinels or hunters. Still other scholars say the co-evolution of wolves and humans was mutually beneficial ...
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★リンクテーブル★
| リンク元 | 「遺伝現象」「genetic phenomenon」 |
| 関連記事 | 「genetic」「phenomena」「genet」 |
「遺伝現象」
「genetic phenomenon」
「genetic」
- adj.
- 遺伝的な、遺伝学的な、遺伝子の、ジェネティックな
「phenomena」
- np.
「genet」
- n.