遺伝子デリバリー、遺伝子送達

WordNet

utter (an exclamation, noise, etc.); "The students delivered a cry of joy"
carry out or perform; "deliver an attack", "deliver a blow"; "The boxer drove home a solid left" (同)drive_home
throw or hurl from the mound to the batter, as in baseball; "The pitcher delivered the ball" (同)pitch
deliver (a speech, oration, or idea); "The commencement speaker presented a forceful speech that impressed the students" (同)present
save from sins (同)redeem, save
bring to a destination, make a delivery; "our local super market delivers"
the act of delivering or distributing something (as goods or mail); "his reluctant delivery of bad news" (同)bringing
the voluntary transfer of something (title or possession) from one party to another (同)livery, legal transfer
the act of delivering a child (同)obstetrical delivery
the event of giving birth; "she had a difficult delivery"
(genetics) a segment of DNA that is involved in producing a polypeptide chain; it can include regions preceding and following the coding DNA as well as introns between the exons; it is considered a unit of heredity; "genes were formerly called factors" (同)cistron, factor
informal term for information; "give me the gen on your new line of computers"

PrepTutorEJDIC

(人・場所に)〈手紙・荷物など〉'を'『配達する』,届ける;〈伝言など〉'を'伝える《+『名』+『to』+『名』》 / (…に)〈打撃・攻撃など〉'を'『加える』;〈球〉'を'投げる《+『名』+『to』+『名』》 / 〈意見など〉'を'『述べる』,〈判決など〉'を'申し渡す / (…から)〈人〉'を'『朽う』,解放する《+『名』+『from』+『名』》 / (…に)…'を'引き渡す《+『名』+『to』+『名』》 / 〈子〉'を'分娩(ぶんべん)させる;〈妊婦〉‘に'分娩させる
〈U〉〈C〉(…への)(手紙・荷物などの)『配達』,便;配達品《+『for』+『名』》 / 〈U〉《文》(…からの)釈放,解放《+『from』+『名』》 / 〈U〉〈C〉分娩(ぶんべん),出産 / 〈U〉〈C〉話しぶり,弁舌 / 〈U〉(野球の)投球[ぶり],(テニスなどの)打ち方
遺伝子

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/08/24 02:12:36」(JST)

wiki en

Electroporator with square wave and exponential decay waveforms for in vitro, in vivo, adherent cell and 96 well electroporation applications. Manufactured by BTX Harvard Apparatus, Holliston MA USA.

Gene delivery is the process of introducing foreign DNA into host cells. Gene delivery is, for example, one of the steps necessary for gene therapy and the genetic modification of crops. There are many different methods of gene delivery developed for a various types of cells and tissues, from bacterial to mammalian. Generally, the methods can be divided into two categories, non-viral and viral.^[1]

Non-viral methods include physical methods such as electroporation, microinjection, gene gun, impalefection, hydrostatic pressure, continuous infusion, and sonication and chemical, such as lipofection. It can also include the use of polymeric gene carriers (polyplexes).^[2]

Virus mediated gene delivery utilizes the ability of a virus to inject its DNA inside a host cell. A gene that is intended for delivery is packaged into a replication-deficient viral particle. Viruses used to date include retrovirus, adenovirus, adeno-associated virus and herpes simplex virus. However, there are drawbacks to using viruses to deliver genes into cells. Viruses can only deliver very small pieces of DNA into the cells, it is labor-intensive and there are risks of random insertion sites, cytophathic effects and mutagenesis.

References

^ Kamimura K, Suda T, Zhang G et al. (2011). "Advances in Gene Delivery Systems". Pharm Med 25 (5): 293–306. doi:10.2165/11594020-000000000-00000.
^ Saul JM, Linnes MP, Ratner BD, Giachelli CM, Pun SH (November 2007). "Delivery of non-viral gene carriers from sphere-templated fibrin scaffolds for sustained transgene expression". Biomaterials 28 (31): 4705–16. doi:10.1016/j.biomaterials.2007.07.026. PMID 17675152.

External links

The 10th US-Japan Symposium on Drug Delivery Systems

UpToDate Contents

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1. 遺伝子治療、ゲノム編集、遺伝子発現抑制の概要overview of gene therapy gene editing and gene silencing [show details]
… Insertion of genes that inhibit immune or inflammatory responses (eg, genes from the adenoviral early region 3 [E3] that is responsible for downregulating host responses) . Deletion of viral genes that may …
2. 小児の吸入剤の送達delivery of inhaled medication in children [show details]
…inhaled morphine . In the future, aerosol delivery of gene constructs could be an important component of therapy for genetic diseases . The ideal aerosol delivery device varies depending upon the medication …
3. 帝王切開に対する麻酔anesthesia for cesarean delivery [show details]
…scheduled and non-urgent, non-emergent cesarean delivery, adequate preoperative fasting should be verified. The preoperative assessment for emergent cesarean delivery should be as comprehensive as time permits …
4. 正常な陣痛および分娩のマネージメントmanagement of normal labor and delivery [show details]
… support by a doula during the birthing process may lower intrapartum analgesia requirements, decrease the rate of operative delivery, and increase satisfaction with the birth experience. The appropriate …
5. 先天異常：評価アプローチbirth defects approach to evaluation [show details]
… 20,000 genes simultaneously using next-generation sequencing techniques. This test is extremely valuable for uncovering changes in Mendelian genes (single genes) responsible…causes of birth defects are also discussed separately. Referral to a genetic specialist is suggested for any child that presents with a single major birth defect or a combination of multiple birth defects…

English Journal

Development of Entry-Targeted Oncolytic Measles Viruses.

Mühlebach MD, Cattaneo R.
Methods in molecular biology (Clifton, N.J.). 2020 ;2058()51-75.
This chapter describes the development of recombinant oncolytic measles viruses (MeV) that selectively enter and destroy tumor cells. The envelope of MeV is a favorable targeting substrate because receptor attachment and membrane fusion functions are separated on two proteins: the hemagglutinin (H)
PMID 31486031

Introduction to Oncolytic Virotherapy.

Engeland CE, Bell JC.
Methods in molecular biology (Clifton, N.J.). 2020 ;2058()1-6.
Oncolytic viruses exploit key hallmarks of cancer for replication in malignant cells, leading to tumor cell lysis, modulation of the tumor microenvironment and in situ vaccination effects. Diverse virus platforms have been developed as oncolytic vectors and designed for improved tumor specificity, i
PMID 31486028

Rapid and Effective Electroporation Protocol for Nannochloropsis oceanica.

Li DW, Balamurugan S, Zheng JW, Yang WD, Liu JS, Li HY.
Methods in molecular biology (Clifton, N.J.). 2020 ;2050()175-179.
Electroporation refers to the application of high strength electric pulse to create transient pores in the membrane, thereby enabling the passage of hydrophilic molecules into the cells. Based on the properties of cell and cell wall, the electroporation parameters vary among the algal species. Here,
PMID 31468492

Japanese Journal

Aerosol Delivery of siRNA to the Lungs. Part 1: Rationale for Gene Delivery Systems

Youngren-Ortiz Susanne R.,Gandhi Nishant S.,España-Serrano Laura,Chougule Mahavir B.
KONA Powder and Particle Journal advpub(0), 2016
… This article reviews the pulmonary route of administration, aerosol delivery devices, characterization of pulmonary drug delivery systems, and discusses the rationale for inhaled delivery of siRNA. … The inhalation route of administration provides local delivery of siRNA therapeutics for the treatment of various pulmonary diseases, however barriers to pulmonary delivery and intracellular delivery of siRNA exists. …
NAID 130005102527

細胞内環境応答性脂質様サーファクタントを基盤とした遺伝子・核酸ナノDDS (特集新たな医療のディメンジョンを模索するオレオサイエンス)

秋田英万
オレオサイエンス 15(3), 115-122,105, 2015-03
NAID 40020372543

A neutral lipid envelope-type nanoparticle composed of a pH-activated and vitamin E-scaffold lipid-like material as a platform for a gene carrier targeting renal cell carcinoma

Akita Hidetaka,Ishiba Ryohei,Togashi Ryohei,Tange Kota,Nakai Yuta,Hatakeyama Hiroto,Harashima Hideyoshi
Journal of controlled release 200, 97-105, 2015-02-28
… We previously reported on the development of a plasmid DNA (pDNA)-encapsulating liposomal nanoparticle (LNP) as a hepatic gene delivery system that is applicable to systemic administration. … The main purpose of the present study was to expand its application to a tumor-targeting gene delivery systemin mice bearing tumors established from a RCC (OS-RC-2). …
NAID 120005567732