gamma-carboxyglutamic acid

• γカルボキシグルタミン酸

関

1-carboxyglutamic acid、gamma-carboxyglutamate、Gla

WordNet

1. street name for lysergic acid diethylamide (同)back breaker, battery-acid, dose, dot, Elvis, loony toons, Lucy in the sky with diamonds, pane, superman, window pane, Zen
2. any of various water-soluble compounds having a sour taste and capable of turning litmus red and reacting with a base to form a salt
3. having the characteristics of an acid; "an acid reaction"
4. a unit of magnetic field strength equal to one-hundred-thousandth of an oersted
5. the 3rd letter of the Greek alphabet
6. a herd of whales

PrepTutorEJDIC

1. 酸性の / 酸味のある,すっぱい(sour) / (言葉・態度などが)厳しい,しんらつな / 酸 / すっぱいもの / 《俗》=LSD
2. ガンマ(ギリシア語アルファベットの第3字Γ,γ;英語のG,gに相当)
3. (特に女性の)魅力的な脚,すんなりした脚

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2014/01/14 23:22:56」(JST)

wiki en

[Wiki en表示]

Carboxyglutamic acid
IUPAC name 3-Aminopropane-1,1,3-tricarboxylic acid
Other names γ-Carboxyglutamate
Identifiers
CAS number	53445-96-8
PubChem	40772
ChemSpider	37241
Jmol-3D images	Image 1
SMILES O=C(O)C(C(=O)O)CC(N)C(=O)O
InChI InChI=1/C6H9NO6/c7-3(6(12)13)1-2(4(8)9)5(10)11/h2-3H,1,7H2,(H,8,9)(H,10,11)(H,12,13) Key: UHBYWPGGCSDKFX-UHFFFAOYAH
Properties
Molecular formula	C6H9NO6
Molar mass	191.14 g/mol
Density	1.649 g/mL
Boiling point	418 °C; 784 °F; 691 K
Except where noted otherwise, data are given for materials in their standard state (at 25 °C (77 °F), 100 kPa)
Infobox references

Carboxyglutamic acid (or the conjugate base, carboxyglutamate), is an uncommon amino acid introduced into proteins by a post-translational carboxylation of glutamic acid residues. This modification is found, for example, in clotting factors and other proteins of the coagulation cascade. This modification introduces an affinity for calcium ions. In the blood coagulation cascade, Vitamin K is required to introduce gamma-carboxylation of clotting factors II, VII, IX, X and protein Z.

References

See also

• Gamma-glutamyl carboxylase

UpToDate Contents

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• 1. ビタミンＫおよびγカルボキシグルタミン酸の合成 vitamin k and the synthesis of gamma carboxyglutamic acid
• 2. ビタミンＫ、γカルボキシグルタミン酸、および凝固剤と他のタンパク質の機能 vitamin k gamma carboxyglutamic acid and the function of coagulation and other proteins
• 3. 第VIII因子および第IX因子の生物学と正常な機能 biology and normal function of factor viii and factor ix
• 4. プロテインＣ欠乏症 protein c deficiency
• 5. プロテインＳ欠乏症 protein s deficiency

English Journal

• Association of matrix γ-carboxyglutamic acid protein levels with insulin resistance and Lp(a) in diabetes: A cross-sectional study.

• Antonopoulos S1, Mylonopoulou M2, Angelidi AM3, Kousoulis AA4, Tentolouris N5.
• Diabetes research and clinical practice.Diabetes Res Clin Pract.2017 Aug;130:252-257. doi: 10.1016/j.diabres.2017.06.015. Epub 2017 Jun 19.
• PMID 28654853

• Calcification in dermal fibroblasts from a patient with GGCX syndrome accompanied by upregulation of osteogenic molecules.

• Okubo Y1,2, Masuyama R3, Iwanaga A1, Koike Y1, Kuwatsuka Y1, Ogi T4, Yamamoto Y5,6, Endo Y6, Tamura H7, Utani A1.
• PloS one.PLoS One.2017 May 11;12(5):e0177375. doi: 10.1371/journal.pone.0177375. eCollection 2017.
• PMID 28494010

• Effects of the combined Herba Epimedii and Fructus Ligustri Lucidi on bone turnover and TGF-β1/Smads pathway in GIOP rats.

• Yang Y1, Nian H1, Tang X1, Wang X2, Liu R3.
• Journal of ethnopharmacology.J Ethnopharmacol.2017 Apr 6;201:91-99. doi: 10.1016/j.jep.2017.02.033. Epub 2017 Feb 27.
• PMID 28254481

Japanese Journal

• A polymorphism of the human matrix gamma-carboxyglutamic acid protein promoter alters binding of an activating protein-1 complex and is associated with altered transcription and serum levels

• FARZANEH-FAR A
• J Biol Chem 276, 32466-32473, 2001
• NAID 80012639128

• Requirement of gamma-carboxyglutamic acid residues for the biological activity of Gas6 : contribution of endogenous Gas6 to the proliferation of vascular smooth muscle cells

• NAKANO T.
• Biochem J 323, 387-392, 1997
• NAID 80009585067

• Cellular Basis for Protein C Deficiency Caused by a Single Amino Acid Substitution at Argl5 in the .GAMMA.-Carboxyglutamic Acid Domain.

• , ,
• The Journal of Biochemistry 120(2), 360-368, 1996
• … It is characteristic of protein C deficiency that most single amino acid replacements result in type I (secretion defect) deficiency. … Arg15 is one of the conservative residues in the γ-carboxyglutamic acid (Gla) domains of the vitamin K-dependent coagulation factors, and is also one of the high frequency multiple mutation sites in protein C deficiency. …
• NAID 130003532970

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★リンクテーブル★

リンク元	「γカルボキシグルタミン酸」「gamma-carboxyglutamate」「1-carboxyglutamic acid」
関連記事	「carboxyglutamic」「gamma」

「γカルボキシグルタミン酸」

　　[★]

英

gamma-carboxyglutamic acid、gamma-carboxyglutamate、1-carboxyglutamic acid、Gla

関

γ-カルボキシグルタミン酸、1-カルボキシグルタミン酸

「gamma-carboxyglutamate」

　　[★]

• γカルボキシグルタミン酸、γ-カルボキシグルタミン酸

関

1-carboxyglutamic acid、gamma-carboxyglutamic acid、Gla

「1-carboxyglutamic acid」

　　[★]

• 1-カルボキシグルタミン酸、γカルボキシグルタミン酸

関

gamma-carboxyglutamate、gamma-carboxyglutamic acid、Gla

「carboxyglutamic」

　　[★]

• gamma-carboxyglutamic acid

「gamma」

　　[★] γ ガンマ