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1. ビタミンＫとγカルボキシグルタミン酸の合成および機能 vitamin k and the synthesis and function of gamma carboxyglutamic acid
2. 第VIII因子および第IX因子の生物学と正常な機能 biology and normal function of factor viii and factor ix
3. ビタミンKの概要 overview of vitamin k
4. プロテインC欠乏症：臨床症状および診断 protein c deficiency clinical manifestations and diagnosis
5. プロテインS欠乏症：臨床症状および診断 protein s deficiency clinical manifestations and diagnosis

English Journal

Decreased Sensory Responses in Osteocalcin Null Mutant Mice Imply Neuropeptide Function.

Patterson-Buckendahl P, Sowinska A, Yee S, Patel D, Pagkalinawan S, Shahid M, Shah A, Franz C, Benjamin DE, Pohorecky LA.SourceCenter of Alcohol Studies Rutgers, The State University of New Jersey, 607 Allison Road, Piscataway, NJ, 08854, USA, buckendp@rci.rutgers.edu.
Cellular and molecular neurobiology.Cell Mol Neurobiol.2012 Feb 17. [Epub ahead of print]
Osteocalcin, the most abundant member of the family of extracellular mineral binding gamma-carboxyglutamic acid proteins is synthesized primarily by osteoblasts. Its affinity for calcium ions is believed to limit bone mineralization. Several of the numerous hormones that regulate synthesis of osteoc
PMID 22350212

A fluorescent method to determine vitamin K-dependent gamma-glutamyl carboxylase activity.

Kaesler N, Schettgen T, Mutucumarana VP, Brandenburg V, Jahnen-Dechent W, Schurgers LJ, Krüger T.SourceDivision of Nephrology and Clinical Immunology, University Hospital of the RWTH Aachen, Pauwelsstrasse 30, 52074 Aachen, Germany.
Analytical biochemistry.Anal Biochem.2012 Feb 15;421(2):411-6. Epub 2011 Dec 2.
The gamma (γ)-glutamyl carboxylase is a key enzyme in vitamin K-dependent carboxylation of proteins involved in hemostasis and inflammation. It is an endoplasmic enzyme posttranslationally converting glutamic acid residues into γ-carboxyglutamic acid residues in proteins. The activity of tissue de
PMID 22210513

Akitake-Kawano Reiko,Seno Hiroshi,Nakatsuji Masato,Kimura Yuto,Nakanishi Yuki,Yoshioka Takuto,Kanda Keitaro,Kawada Mayumi,Kawada Kenji,Sakai Yoshiharu,Chiba Tsutomu
Carcinogenesis 34(7), 1567-1574, 2013-07
… Growth arrest-specific gene (Gas) 6 is a γ-carboxyglutamic acid domain-containing protein, which shares 43% amino acid identity with protein S. …
NAID 120005477205

須原義智,和田昭盛,中川公恵 [他],鎌尾まや,津川尚子,岡野登志夫
ビタミン 85(5・6), 271-279, 2011-06-25
… Vitamin K is a fat-soluble vitamin and a well-known cofactor for γ-glutamyl carboxylase (GGCX), an enzyme that converts specific glutamic acid residues in several proteins to γ-carboxyglutamic acid (Gla) residues related to blood coagulation and bone formation in the vitamin K cycle. …
NAID 110008686087

加藤徳介,渡辺誠,黒木亜紀 [他],小椋陽介,杉崎徹三,秋澤忠男
昭和医学会雑誌 69(2), 174-181, 2009
慢性腎不全患者における最大の死因は心血管系合併症であり，その機序として動脈石灰化が注目されている．また近年，ビタミンK（VitK）の血管石灰化予防効果が報告されている．しかし，尿毒症下での血管石灰化機序とVitKの役割はいまだ不明な点が多い．そこで活性型ビタミンD3（VitD3）誘導血管石灰化腎不全モデルを作成し，腎不全病態下におけるVitK2の血管石灰化抑制作用をin vivoで検討した．方法と …
NAID 130000852967