The Journal of organic chemistry.J Org Chem.2015 Jun 19;80(12):6250-8. doi: 10.1021/acs.joc.5b00685. Epub 2015 Jun 1.
To enable in vivo analysis of the kinetics of vitamin B1 (thiamine) and its derivatives by positron emission tomography (PET), (11)C-labeled thiamine ([(11)C]-1) has been synthesized. This was carried out via a rapid, multistep synthesis consisting of Pd(0)-mediated C-[(11)C]methylation of a thiazol
High-throughput screening of small molecules identifies hepcidin antagonists.
Fung E1, Sugianto P, Hsu J, Damoiseaux R, Ganz T, Nemeth E.
Molecular pharmacology.Mol Pharmacol.2013 Mar;83(3):681-90. doi: 10.1124/mol.112.083428. Epub 2013 Jan 4.
Anemia of inflammation (AI) is common in patients with infection, autoimmune diseases, cancer, and chronic kidney disease. Unless the underlying condition can be reversed, treatment options are limited to erythropoiesis-stimulating agents with or without intravenous iron therapy, modalities that are
Due to genetic defects or illness some individuals require higher amounts of thiamin than are typically provided by the diet. Lipid-soluble thiamin precursors can achieve high blood levels of thiamin and result in increased concentrations in the central nervous system. High intakes of thiamin have b
Fursultiamin information including symptoms, causes, diseases, symptoms, treatments, and other medical and health issues. ... Introduction: Fursultiamin Description of Fursultiamin Fursultiamin: Compound used for therapy of ...
Fursultiamin (Science: chemical) N-((4-amino-2-methyl-5-pyrimidinyl)methyl)-n-(4-hydroxy-1-methyl-2-(((tetrahydro-2-furanyl)methyl)dithio)-1-butenyl)formamide. Compound used for therapy of thiamine deficiency. It has also been ...