WordNet

a complex consisting of an organic base in association with hydrogen chloride

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/12/09 04:57:05」(JST)

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Flavoxate is an anticholinergic with antimuscarinic effects. Its muscle relaxant properties may be due to a direct action on the smooth muscle rather than by antagonizing muscarinic receptors.

Clinical uses

Flavoxate is used to treat urinary bladder spasms. It is available under the trade name Urispas (Paladin),Genurin (by Recordati, Italy) in Italy and KSA,Uritac by El Saad company in Syria, under the name Bladderon by Nippon Shinyaku of Japan, or Bladuril in Chile.

Flavoxate is indicated for symptomatic relief of interstitial cystitis, dysuria, urgency, nocturia, suprapubic pain, frequency and incontinence as may occur in cystitis, prostatitis, urethritis, urethrocystitis/urethrotrigonitis.

Side effects

Flavoxate is generally well tolerated, but can potentially cause, vomiting, upset stomach, dry mouth or throat, blurred vision, eye pain, and increased sensitivity of your eyes to light.

Contraindications

Flavoxate is contraindicated in patients who have any of the following obstructive conditions: pyloric or duodenal obstruction, obstructive intestinal lesions or ileus, achalasia, gastrointestinal hemorrhage and obstructive uropathies of the lower urinary tract.

References

Brenner, G. M. (2000). Pharmacology. Philadelphia, PA: W.B. Saunders Company. ISBN 0-7216-7757-6
Canadian Pharmacists Association (2000). Compendium of Pharmaceuticals and Specialties (25th ed.). Toronto, ON: Webcom. ISBN 0-919115-76-4

U.S. National Library of Medicine, National Institutes of Health. "Flavoxate". PubMed Health. http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0000753

UpToDate Contents

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English Journal

Possible involvement of calcium channels and plasma membrane receptors on Staurosporine-induced neurite outgrowth.

Zhaleh H, Azadbakht M, Bidmeshki Pour A.SourceDepartment of Biology, Faculty of Science, Razi University, Taqe Bostan, Baghe Abrisham, 6714967346, Kermanshah, Iran. Department of Chemical Biotechnology Engneering, Science and Research Branch, Islamic Azad University, Kermanshah, Iran.
Bosnian journal of basic medical sciences / Udruženje basičnih mediciniskih znanosti = Association of Basic Medical Sciences.Bosn J Basic Med Sci.2012 Feb;12(1):20-5.
Staurosporine as a protein kinases inhibitor induced cell death or neurite outgrowth in PC12 cells. We investigated the involvement of calcium channel and plasma membrane receptors on staurosporine inducing neurite outgrowth in PC12 cells. PC12 cells were preincubated with NMDA receptor inhibitors (
PMID 22364299

Molecularly imprinted polymer for selective extraction of 3-methylflavone-8-carboxylic acid from human urine followed by its determination using zwitterionic hydrophilic interaction liquid chromatography.

Rao RN, Maurya PK, Kuntamukkala R, Vitthal WD, Talluri MV.SourceHPLC Group, Analytical Chemistry Division, Discovery Laboratory Indian Institute of Chemical Technology (IICT), Tarnaka, Hyderabad, Andhra Pradesh, India. rnrao@iict.res.in
Journal of separation science.J Sep Sci.2011 Nov;34(22):3265-71. doi: 10.1002/jssc.201100560. Epub 2011 Oct 14.
A novel water-compatible molecularly imprinted SPE combined with zwitterionic hydrophilic interaction liquid chromatography method for selective extraction and determination of 3-methylflavone-8-carboxylic acid (MFA), the main active metabolite of flavoxate in human urine, was developed and validate
PMID 21998024

Japanese Journal

夜間頻尿に対する塩酸フラボキサート就寝前投与の効果

嘉手川豪心,菅谷公男,大城吉則,宮里実,安次富勝博,名嘉栄勝,大城琢磨,田崎新資,西島さおり,諸角誠人,大湾知子
西日本泌尿器科 71(12), 637-642, 2009-12-20
NAID 10026433343

夜間頻尿を有するα1アドレナリン受容体遮断薬投与中の前立腺肥大症患者に対する塩酸フラボキサートの有効性の検討

加藤忍,日下守,白木良一 [他]
泌尿器科紀要 54(3), 173-177, 2008-03
塩酸タムスロシンあるいはナフトピジルを1ヵ月以上投与しても夜間排尿回数が2回以上の前立腺肥大症患者52例(平均年齢72.1歳)を対象として, 塩酸フラボキサート400～600mg/日を8～12週投与し, その有用性と安全性を検討した。塩酸フラボキサート投与前後で夜間排尿回数は3.8回→2.7回へ有意に減少し, 国際前立腺症状スコア, QOLスコア, 前立腺肥大症影響度ス …
NAID 120001178020

「フラボキサート」

Flavoxate
Systematic (IUPAC) name
	2-(1-piperidyl)ethyl 3-methyl-4-oxo-2-phenylchromene-8-carboxylate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a682706
Pregnancy cat.	?
Legal status	?
Identifiers
CAS number	15301-69-6
ATC code	G04BD02
PubChem	CID 3354
DrugBank	DB01148
ChemSpider	3237
UNII	3E74Y80MEY
KEGG	D07961
ChEBI	CHEBI:5088
ChEMBL	CHEMBL1493
Chemical data
Formula	C24H25NO4
Mol. mass	391.46 g/mol
	SMILES O=C(OCCN1CCCCC1)c4cccc2c4O/C(=C(\C2=O)C)c3ccccc3;
	InChI InChI=1S/C24H25NO4/c1-17-21(26)19-11-8-12-20(23(19)29-22(17)18-9-4-2-5-10-18)24(27)28-16-15-25-13-6-3-7-14-25/h2,4-5,8-12H,3,6-7,13-16H2,1H3 ; Key:SPIUTQOUKAMGCX-UHFFFAOYSA-N ;
(what is this?) (verify);

　　[★]

英: flavoxate
同: フラボキセート
化: フラボキサート塩酸塩塩酸フラボキサート flavoxate hydrochloride
商: アポラキート、ウロステート、サワダロン、ジステリンク、ハルニン、フラボサート、フラボネート、ブラダロン、フレキシン、プログット、ボラボラン、ユリナロン、ラトボレール、ルアダン、ロラーム
関: その他の泌尿生殖器官及び肛門用薬

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フラボキサート : 約 11,700 件
フラボキセート : 約 35 件

「フラボキサート塩酸塩」

　　[★]

英: flavoxate hydrochloride
関: フラボキサート、塩酸フラボキサート

「URISPAS」

　　[★]

関: flavoxate hydrochloride

「flavoxate」

　　[★]

フラボキサート、フラボキセート

関: flavoxate hydrochloride

「hydrochloride」

　　[★] 塩酸塩、ハイドロクロライド　

リンク元	「フラボキサート」「フラボキサート塩酸塩」「URISPAS」
関連記事	「flavoxate」「hydrochloride」

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案内

flavoxate hydrochloride