関: ascorbic acid、L-ascorbic acid、vitamin C

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1. 成人における鉄欠乏性貧血の治療treatment of iron deficiency anemia in adults [show details]
…over-the-counter preparations include heme iron polypeptide, carbonyl iron, ferric citrate, ferrous ascorbate, and ferrous succinate . Among these, there is no evidence that one is more effective than another …
2. Anesthesia for placement of ventricular assist devicesanesthesia for placement of ventricular assist devices [show details]
…treatment include norepinephrine and vasopressin; in refractory cases, methylene blue, angiotensin II, vitamin C, or hydroxycobalamin have been administered . Persistent postoperative vasoplegia has been associated …
3. Prevention of contrast-induced acute kidney injury associated with computed tomographyprevention of contrast induced acute kidney injury associated with computed tomography [show details]
4. 水溶性ビタミンの概要overview of water soluble vitamins [show details]
…determinants of functional vitamin C status. However, plasma and leukocyte vitamin C levels are the mainstay for assessment and are reasonably well correlated with vitamin C intake. High-performance liquid …
5. メトヘモグロビン血症の臨床的特徴、診断、および治療clinical features diagnosis and treatment of methemoglobinemia [show details]
… hemoglobin with its iron in the ferrous [reduced; Fe⁺⁺] state) or a mutant globin that facilitates spontaneous oxidation of the ferrous iron to ferric state.… options include methylene blue (MB) orally at a dose of 100 to 300 mg/day orally or ascorbic acid (vitamin C), typically 1000 mg three times per day; however, controlled studies have not been performed, and …

English Journal

Combinatorial therapeutic approach for treatment of oral squamous cell carcinoma.

Bharadwaj R, Sahu BP, Haloi J, Laloo D, Barooah P, Keppen C, Deka M, Medhi S.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)572-585.
Oral squamous cell carcinoma (OSCC) is one of the common type of cancer in humans. A combinatorial approach has been done by using paclitaxel (PTX), 5-fluorouracil (5-FU) and ascorbic acid (AA) loaded solid lipid nanoparticles (SLN) for its treatment. SLN were made by high-speed homogenization and u
PMID 30831033

Therapeutic hypothermia effectively reduces elevated extracellular ascorbate concentrations caused by acute spinal cord injury.

Zhang Y, Lv Y, Ji W, Zhou R, Gao S, Zhou F.
Artificial cells, nanomedicine, and biotechnology. 2019 Dec;47(1)22-29.
In recent years, systemic hypothermia has taken the spotlight for its use in spinal cord injury (SCI) research fields, but detailed molecular mechanisms are still not fully understood. In this study, we use an online-electrochemical system (OECS) to in vivo continuously monitor the ascorbate of the
PMID 30526134

Antioxidant activity and antibacterial evaluation of new thiazolin-4-one derivatives as potential tryptophanyl-tRNA synthetase inhibitors.

Stana A, Vodnar DC, Marc G, Benedec D, Tiperciuc B, Tamaian R, Oniga O.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)898-908.
The rapid emergence of bacterial resistance to antibiotics currently available for treating infectious diseases requires effective antimicrobial agents with new structural profiles and mechanisms of action. Twenty-three thiazolin-4-one derivatives were evaluated for their antibacterial activity by d
PMID 30938216

Japanese Journal

Monoamine-dependent Production of Reactive Oxygen Species Catalyzed by Pseudoperoxidase Activity of Human Hemoglobin(Biochemistry & Molecular Biology)

KAWANO Tomonori,PINONTOAN Reinhard,HOSOYA Hishoshi,MUTO Sshoshi
Bioscience, biotechnology, and biochemistry 66(6), 1224-1232, 2002-06-23
… However, the cell-free Hb molecule has intrinsic toxicity to the tissue since harmful reactive oxygen species (ROS) are readily produced during autoxidation of Hb from the ferrous state to the ferric state, and the cell-free Hb also causes distortion in the oxidant/antioxidant balance in the tissues. … We also observed that PEA increases the Hb-catalyzed monovalent oxidation of ascorbate to ascorbate free radicals (Asc^・). …
NAID 110002693810

Antioxidant Effects of Albumin-bound Sulfur in Lipid Peroxidation of Rat Liver Microsomes

OGASAWARA Yuki,ISODA Shinji,TANABE Shinzou
Biological & pharmaceutical bulletin 22(5), 441-445, 1999-05-15
… Lipid peroxidation was induced either chemically by ferrous ions and ascorbate or enzymatically by carbon tetrachloride or tert-butyl hydroperoxide as indicated by the increase in thiobarbituric acid reactive substances (TBA-RS) and oxygen consumption. …
NAID 110003639688

Microencapsulated Ferrous Sulfate to Fortify Cow Milk: Absorption and Distribution in Mice.

BOCCIO Jose R.,ZUBILLAGA Marcela B.,CARO Ricardo A.,LYSIONEK Alexis E.,SALGUEIRO María J.,CALMANOVICI Gabriela P.,SARABIA María I.,WEILL Ricardo
Ｊｏｕｒｎａｌ　ｏｆ　Ｎｕｔｒｉｔｉｏｎａｌ　Ｓｃｉｅｎｃｅ　ａｎｄ　Ｖｉｔａｍｉｎｏｌｏｇｙ　 44(3), 381-389, 1998
… To determine the absorption and biodistribution of iron from microencapsulated ferrous sulfate (SFE-171), used to fortify dairy products with iron, a comparative study in four groups of 30 mice each was carried out. … In two of the groups, the absorption of iron from ferrous ascorbate in water (13.3±4.3%) and from ferrous sulfate in water (12.7±3.9%) was determined and taken as reference standards. …
NAID 130001370434