English Journal

Successful treatment of empyema thoracis with polymethylmethacrylate antibiotic-impregnated beads in the guinea pig.

Mavroudis C, Katzmark SL, Ganzel BL, Gray LA, Polk HC.
The Annals of thoracic surgery. 1988 Dec;46(6)615-8.
Two hundred nine Duncan-Harley guinea pigs had intrathoracic inoculation with 10(8) Staphylococcus aureus, accompanied by blood and umbilical tape. One hundred fifty-two animals were excluded because of clinical recovery, early death, or complications related to intrathoracic polymethylmethacrylate
PMID 3196101

Effect of hemothorax on experimental empyema thoracis in the guinea pig.

Mavroudis C, Ganzel BL, Katzmark S, Polk HC.
The Journal of thoracic and cardiovascular surgery. 1985 Jan;89(1)42-9.
An experimental model for empyema thoracis in the Duncan-Harley guinea pig is introduced. Empyema thoracis development and early death (less than 14 days after bacterial inoculation) were noted after various concentrations and species were inoculated into the pleural space with a piece of umbilical
PMID 3880847

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