WordNet

any of a group of compounds that are inactive precursors of enzymes and require some change (such as the hydrolysis of a fragment that masks an active enzyme) to become active (同)zymogen
a substance from which another substance is formed (especially by a metabolic reaction)
a person who goes before or announces the coming of another (同)forerunner
any of several complex proteins that are produced by cells and act as catalysts in specific biochemical reactions

PrepTutorEJDIC

(…の)前朕,前触れ《+『of』+『名』》
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1. レニン－アンギオテンシン系の概要overview of the renin angiotensin system [show details]
…cells called the juxtaglomerular cells These cells synthesize the precursor, prorenin, which is cleaved into the active proteolytic enzyme, renin. Active renin is then stored in and released from secretory …
2. 副腎酵素阻害剤および抗アドレナリン薬の薬理および毒性pharmacology and toxicity of adrenal enzyme inhibitors and adrenolytic agents [show details]
… interfering with one or more of the enzymes in the steroidogenic pathway . These compounds have been used to study the enzymes involved in steroid synthesis,… This tends to override the drug-induced cortisol blockade but can also result in accumulation of precursor steroids. These drugs usually do not cause adrenal insufficiency in patients with normal hypoth …
3. 早産児や正期産児にとっての長鎖多価不飽和脂肪酸（LCPUFA）long chain polyunsaturated fatty acids lcpufa for preterm and term infants [show details]
…of desaturase and elongase enzymes, and the n-6 and n-3 LCPUFAs compete for these enzymes in their biosynthesis . Biosynthesis depends on precursor availability and enzyme activity, which may be limiting …
4. 鉄芽球性貧血の原因および病態生理causes and pathophysiology of the sideroblastic anemias [show details]
… I and IV . tRNA nucleotidyl transferase (TRNT1) – The TRNT1 enzyme is essential for processing all cytosolic and mitochondrial precursor tRNAs by adding the trinucleotide CCA to their 3" end for protein …
5. 心筋炎の病因および発症機序etiology and pathogenesis of myocarditis [show details]
…endomyocardial biopsy specimens show higher levels of a TNFa precursor and the TNFa converting enzyme (TACE), which converts the precursor to its mature form within the myocytes and interstitial cells…

English Journal

Sardine procalcitonin amino-terminal cleavage peptide has a different action from calcitonin and promotes osteoblastic activity in the scales of goldfish.

Kase Y1, Ikari T1, Sekiguchi T1, Sato M1, Ogiso S1, Kawada T2, Matsubara S2, Satake H2, Sasayama Y1, Endo M3, Kitamura KI4, Hattori A5, Watanabe TX6, Maruyama Y5, Watanabe Y7, Funahashi H8, Kambegawa A9, Suzuki N10.
Comparative biochemistry and physiology. Part A, Molecular & integrative physiology.Comp Biochem Physiol A Mol Integr Physiol.2017 Sep;211:77-83. doi: 10.1016/j.cbpa.2017.06.007. Epub 2017 Jun 11.
PMID 28614698

Biotransformation of pyridoxal 5'-phosphate from pyridoxal by pyridoxal kinase (pdxY) to support cadaverine production in Escherichia coli.

Kim JH1, Kim J1, Kim HJ1, Sathiyanarayanan G2, Bhatia SK2, Song HS1, Choi YK1, Kim YG3, Park K4, Yang YH5.
Enzyme and microbial technology.Enzyme Microb Technol.2017 Sep;104:9-15. doi: 10.1016/j.enzmictec.2017.05.002. Epub 2017 May 13.
PMID 28648182

Manuka honey (Leptospermum scoparium) inhibits jack bean urease activity due to methylglyoxal and dihydroxyacetone.

Rückriemen J1, Klemm O1, Henle T2.
Food chemistry.Food Chem.2017 Sep 1;230:540-546. doi: 10.1016/j.foodchem.2017.03.075. Epub 2017 Mar 15.
PMID 28407946

Japanese Journal

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease

Kizuka Yasuhiko,Kitazume Shinobu,Fujinawa Reiko,Saito Takashi,Iwata Nobuhisa,Saido Takaomi C.,Nakano Miyako,Yamaguchi Yoshiki,Hashimoto Yasuhiro,Staufenbiel Matthias,Hatsuta Hiroyuki,Murayama Shigeo,Manya Hiroshi,Endo Tamao,Taniguchi Naoyuki
EMBO Molecular Medicine 7(2), 175-189, 2015-02-01
… The β-site amyloid precursor protein cleaving enzyme-1 (BACE1), an essential protease for the generation of amyloid-β (Aβ) peptide, is a major drug target for Alzheimer's disease (AD). … Analysis of knockout mice lacking the biosynthetic enzyme for bisecting GlcNAc, GnT-III (Mgat3), revealed that cleavage of Aβ-precursor protein (APP) by BACE1 is reduced in these mice, resulting in a decrease in Aβ plaques and improved cognitive function. …
NAID 120005549837

Effect of High Glucose Levels on Amyloid β Production in Retinas of Spontaneous Diabetes Mellitus Otsuka Long-Evans Tokushima Fatty Rats

Nagai Noriaki,Ito Yoshimasa,Tanino Tadatoshi
Biological and Pharmaceutical Bulletin 38(4), 601-610, 2015
… In the retinas of Long-Evans Tokushima Otsuka (LETO) rats used as normal controls and OLETF rats, no expression of neprilysin (NEP), which degrades Aβ, was detected, and the expression levels of genes associated with Aβ production (amyloid precursor protein, β site APP cleaving enzyme, and presenilin) and Aβ1–42 levels in the retinas of 60-week-old OLETF rats with diabetes mellitus were significantly higher than in 60-week-old LETO rat retinas. …
NAID 130005062266

Chitosan-mediated formation of biomimetic silica nanoparticles : An effective method for manganese peroxidase immobilization and stabilization(BIOCHEMICAL ENGINEERING)

Luan Pan-Pan,Jiang Yan-Jun,Zhang Song-Ping [他],Gao Jing,Su Zhi-Guo,Ma Guang-Hui,Zhang Yu-Fei
Journal of bioscience and bioengineering 118(5), 575-582, 2014-11
… Our work here, for the first time, reported the use of chitosan-mediated biomimetic silica nanoparticles in enzyme immobilization. … In order to make clear the relationship among silicification process, silica nanoparticle structure and immobilized enzyme activity, a mechanism of chitosan-mediated silicification using sodium silicate as the silica source was primarily evaluated. … Furthermore, the effect of enzyme on silicification process was also investigated. …
NAID 110009894844