WordNet

come on stage
to come or go into; "the boat entered an area of shallow marshes" (同)come_in, get_into, get_in, go_into, go in, move into
become a participant; be involved in; "enter a race"; "enter an agreement"; "enter a drug treatment program"; "enter negotiations" (同)participate
a thin layer covering something; "a second coat of paint" (同)coat
a decorative texture or appearance of a surface (or the substance that gives it that appearance); "the boat had a metallic finish"; "he applied a coat of a clear finish"; "when the finish is too thin it is difficult to apply evenly" (同)finish, finishing
a heavy fabric suitable for coats
omnivorous mammal of Central America and South America (同)coati-mondi, coati-mundi, coon cat, Nasua narica
of or relating to the enteron (同)enteral

PrepTutorEJDIC

…‘に'『入る』,入り込む / 〈弾丸などが〉…‘を'突き通す,‘に'入り込む(penetrate) / …‘の'『一員となる』,‘に'入る;…‘に'参加する / (…に)〈人〉‘を'入学させる;(競争などに)〈人・動物など〉‘を'参加させる《+『名』+『in』(『for』)+『名』》 / (…に)…‘を'記入する,登録する《+『名』+『in』(『into, on』)+『名』》 / 〈新しい生活・局面など〉‘に'入る / 〈異議など〉‘を'正式に申し出る / 『入る』 / 登場する
〈C〉(ペンキなどの)上塗り,塗装;(食物の)ころも,皮 / 〈U〉上旦用の布地
ハナグマ(熱帯アメリカに住むアライグマ類の肉食動物)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/28 01:07:08」(JST)

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An enteric coating is a polymer barrier applied on oral medication. This helps by protecting drugs from the acidity of the stomach.^[1]

Most enteric coatings work by presenting a surface that is stable at the highly acidic pH found in the stomach, but breaks down rapidly at a less acidic (relatively more basic) pH. For example, they will not dissolve in the gastric acids of the stomach (pH ~3), but they will in the alkaline (pH 7-9) environment present in the small intestine. Materials used for enteric coatings include fatty acids, waxes, shellac, plastics, and plant fibers.

Drugs that have an irritant effect on the stomach, such as aspirin, can be coated with a substance that will dissolve only in the small intestine. Likewise, certain groups of proton pump inhibitors (esomeprazole, omeprazole, pantoprazole and all grouped azoles) are acid-activated. For such types of drugs, enteric coating added to the formulation tends to avoid activation in the mouth and esophagus. However, it has been shown that this may lead to incomplete inhibition of platelets.^[2]

Recently, some companies have begun to utilize enteric coatings on fish oil (omega-3 fatty acids) supplements. The coating prevents the fish oil capsules from being digested in the stomach, which has been known to cause a fishy reflux.

Sometimes the abbreviation "EC" is added beside the name of the drug to indicate that it has an enteric coating.

Composition of coatings

Methyl acrylate-methacrylic acid copolymers
Cellulose acetate succinate
Hydroxy propyl methyl cellulose phthalate
hydroxy propyl methyl cellulose acetate succinate (hypromellose acetate succinate)
polyvinyl acetate phthalate (PVAP)
methyl methacrylate-methacrylic acid copolymers
Shellac
Cellulose acetate trimellitate
Sodium alginate
Zein

References

^ http://www.wellnessletter.com/ucberkeley/feature/should-your-aspirin-wear-a-coat/#
^ http://circ.ahajournals.org/content/early/2012/12/04/CIRCULATIONAHA.112.117283.abstract

UpToDate Contents

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1. 非ステロイド性抗炎症剤（NSAIDs）（アスピリンを含む）：胃十二指腸障害の一次予防 nsaids including aspirin primary prevention of gastroduodenal toxicity
2. アスピリンの無効および耐性 nonresponse and resistance to aspirin
3. 心血管疾患の二次および一次予防におけるアスピリンの利益とリスク benefits and risks of aspirin in secondary and primary prevention of cardiovascular disease
4. 小児および思春期におけるクローン病マネージメントの概要 overview of the management of crohn disease in children and adolescents
5. Diagnostic peritoneal lavage

English Journal

Novel starch based nano scale enteric coatings from soybean meal for colon-specific delivery.

Sivapragasam N1, Thavarajah P2, Ohm JB3, Ohm JB3, Margaret K4, Thavarajah D5.
Carbohydrate polymers.Carbohydr Polym.2014 Oct 13;111:273-9. doi: 10.1016/j.carbpol.2014.04.091. Epub 2014 May 2.
Soybean meal was used to isolate resistant starch and produce nanoparticles, which could be potential coating materials for colonic nutrient and drug deliveries. The nanoparticles were in 40±33.2nm ranges. These nanoparticles were stable under simulated human physiological conditions. The degrees o
PMID 25037352

Design of lipotomes as a novel dual functioning nanocarrier for bioavailability enhancement of lacidipine: In-vitro and in-vivo characterization.

ElKasabgy NA1, Elsayed I2, Elshafeey AH3.
International journal of pharmaceutics.Int J Pharm.2014 Sep 10;472(1-2):369-79. doi: 10.1016/j.ijpharm.2014.06.048. Epub 2014 Jun 27.
Lipotomes were designed to enhance lacidipine's oral bioavailability by improving its solubility and enhancing the oral lymphatic uptake. Lipotomes were prepared using cetyl alcohol and Tween(®) 80 using a thin film hydration technique. Cetyl alcohol was chosen for imparting a lipophilic environmen
PMID 24979531