内在性抗原、内因性抗原

WordNet

of or resembling an endogen
derived or originating internally (同)endogenic
any substance (as a toxin or enzyme) that stimulates an immune response in the body (especially the production of antibodies)

PrepTutorEJDIC

(生物が)内部から成長する,内性の,内因性の
抗原(生物の体内にはいって免疫体を作る物質)

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1. 適応細胞性免疫応答 the adaptive cellular immune response
2. 抗原提示細胞 antigen presenting cells
3. 前立腺癌のスクリーニング screening for prostate cancer
4. 前立腺特異的抗原（PSA）の測定 measurement of prostate specific antigen
5. 免疫グロブリンの機能および臨床応用 function and clinical applications of immunoglobulins

English Journal

DNA fusion vaccine designs to induce tumor-lytic CD8+ T-cell attack via the immunodominant cysteine-containing epitope of NY-ESO 1.

Campos-Perez J, Rice J, Escors D, Collins M, Paterson A, Savelyeva N, Stevenson FK.SourceGenetic Vaccine Group, Cancer Sciences Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
International journal of cancer. Journal international du cancer.Int J Cancer.2013 Sep 15;133(6):1400-7. doi: 10.1002/ijc.28156. Epub 2013 Apr 11.
The cancer/testis antigen NY-ESO-1 contains an immunodominant HLA-A2-binding peptide (SLLMWITQC), designated S9C, an attractive target for vaccination against several human cancers. As cysteine contains a reactive -SH, the oxidation status of exogenous synthetic peptide is uncertain. We have designe
PMID 23494538

Efficacy of DHMEQ, a NF-κB Inhibitor, in Islet Transplantation: II. Induction DHMEQ Treatment Ameliorates Subsequent Alloimmune Responses and Permits Long-Term Islet Allograft Acceptance.

Watanabe M, Yamashita K, Kamachi H, Kuraya D, Koshizuka Y, Shibasaki S, Asahi Y, Ono H, Emoto S, Ogura M, Yoshida T, Ozaki M, Umezawa K, Matsushita M, Todo S.Source1 First Department of Surgery, Hokkaido University School of Medicine, Sapporo, Japan. 2 Department of Transplant Surgery, Hokkaido University School of Medicine, Sapporo, Japan. 3 Department of Molecular Target Medicine Screening, Aichi Medical University, Nagakute, Japan. 4 Address correspondence to: Kenichiro Yamashita, M.D. and Satoru Todo, M.D., Department of Transplant Surgery, Hokkaido University School of Medicine, N-15 W-7, Kita-Ku, Sapporo 060-8638, Japan.
Transplantation.Transplantation.2013 Sep 15;96(5):454-62. doi: 10.1097/TP.0b013e31829b077f.
BACKGROUND: Long-term graft deterioration remains a major obstacle in the success of pancreatic islet transplantation (PITx). Antigen-independent inflammatory and innate immune responses strengthen subsequent antigen-dependent immunity; further, activation of nuclear factor (NF)-κB plays a key role
PMID 23860082

Long-gradient separations coupled with selected reaction monitoring for highly sensitive, large scale targeted protein quantification in a single analysis.

Shi T, Fillmore TL, Gao Y, Zhao R, He J, Schepmoes AA, Nicora CD, Wu C, Chambers JL, Moore RJ, Kagan J, Srivastava S, Liu AY, Rodland KD, Liu T, Camp DG, Smith RD, Qian WJ.AbstractLong-gradient separations coupled to tandem MS were recently demonstrated to provide a deep proteome coverage for global proteomics; however, such long-gradient separations have not been explored for targeted proteomics. Herein, we investigate the potential performance of the long-gradient separations coupled with selected reaction monitoring (LG-SRM) for targeted protein quantification. Direct comparison of LG-SRM (5 h gradient) and conventional LC-SRM (45 min gradient) showed that the long-gradient separations significantly reduced background interference levels and provided an 8- to 100-fold improvement in LOQ for target proteins in human female serum. Based on at least one surrogate peptide per protein, an LOQ of 10 ng/mL was achieved for the two spiked proteins in non-depleted human serum. The LG-SRM detection of seven out of eight endogenous plasma proteins expressed at ng/mL or sub-ng/mL levels in clinical patient sera was also demonstrated. A correlation coefficient of >0.99 was observed for the results of LG-SRM and ELISA measurements for prostate-specific antigen (PSA) in selected patient sera. Further enhancement of LG-SRM sensitivity was achieved by applying front-end IgY14 immunoaffinity depletion. Besides improved sensitivity, LG-SRM potentially offers much higher multiplexing capacity than conventional LC-SRM due to an increase in average peak widths (~3-fold) for a 300-min gradient compared to a 45-min gradient. Therefore, LG-SRM holds great potential for bridging the gap between global and targeted proteomics due to its advantages in both sensitivity and multiplexing capacity.
Analytical chemistry.Anal Chem.2013 Sep 4. [Epub ahead of print]
Long-gradient separations coupled to tandem MS were recently demonstrated to provide a deep proteome coverage for global proteomics; however, such long-gradient separations have not been explored for targeted proteomics. Herein, we investigate the potential performance of the long-gradient separatio
PMID 24004026

Japanese Journal

In vivo imaging in autoimmune diseases in the central nervous system

Allergology International 65(3), 235-242, 2016
NAID 130005165880

Rapid Normalization of High Glutamic Acid Decarboxylase Autoantibody Titers and Preserved Endogenous Insulin Secretion in a Patient with Diabetes Mellitus: A Case Report and Literature Review