WordNet

set the speed, duration, or execution of; "we time the process to manufacture our cars very precisely"
a period of time considered as a resource under your control and sufficient to accomplish something; "take time to smell the roses"; "I didnt have time to finish"; "it took more than half my time"
a suitable moment; "it is time to go"
adjust so that a force is applied and an action occurs at the desired time; "The good player times his swing so as to hit the ball squarely"
an indefinite period (usually marked by specific attributes or activities); "he waited a long time"; "the time of year for planting"; "he was a great actor in his time"
regulate or set the time of; "time the clock"
the continuum of experience in which events pass from the future through the present to the past
an instance or single occasion for some event; "this time he succeeded"; "he called four times"; "he could do ten at a clip" (同)clip
a persons experience on a particular occasion; "he had a time holding back the tears"; "they had a good time together"
assign a time for an activity or event; "The candidate carefully timed his appearance at the disaster scene"
call to mind; "His words echoed John F. Kennedy" (同)recall
the repetition of a sound resulting from reflection of the sound waves; "she could hear echoes of her own footsteps" (同)reverberation, sound reflection, replication
a close parallel of a feeling, idea, style, etc.; "his contention contains more than an echo of Rousseau"; "Napoleon III was an echo of the mighty Emperor but an infinitely better man"
a reflected television or radio or radar beam
an imitation or repetition; "the flower arrangement was created as an echo of a clients still life"
a reply that repeats what has just been said
shrub with terminal tufts of elongated leaves used locally for thatching and clothing; thick sweet roots are used as food; tropical southeastern Asia, Australia and Hawaii (同)Cordyline terminalis
the syllable naming the seventh (subtonic) note of any musical scale in solmization (同)te, si
the regulation of occurrence, pace, or coordination to achieve a desired effect (as in music, theater, athletics, mechanics)
the time when something happens
a more or less definite period of time now or previously present; "it was a sign of the times"

PrepTutorEJDIC

〈U〉《冠詞をつけずに》(空間に対しての)『時間』,時 / 〈U〉(時計で示される)『時刻』 / 〈U〉(ある方式で決められる)『時間』,標準時 / 〈C〉〈U〉(特定の)『時』,おり,ころ / 〈U〉《しばしば A ~》(ある長さの)『時間』,期間 / 〈U〉(要する)『時間』;暇 / 《しばしば複数形で》(歴史上の)『時代』 / 《複数形で》時勢,景気 / 《one's ~》(個人の)一生;若いころ;生涯の特定の時期 / 〈U〉《しばしば A ~》(ある経験をした)『時間』 / 〈C〉『…回』,度 / 〈C〉『…倍』 / …の時間を定める / (…に)…の調子を合わせる《+名+to+名》 / …の時間を計る
〈C〉〈U〉『反響』[音];『こだま』,山びこ / 〈C〉〈U〉(意見・心情などに対する)共鳴,反応 / 〈C〉〈U〉(他人の行為・意見などの)繰り返し,まね《+『of』+『名』》;(…からの)影響《+『from』+『名』》;〈C〉まねをする人 / 〈場所が〉…‘を'『反響させる』 / 〈人の言葉・意見〉‘を'『そのまま繰り返す』,そっくりまねる / (…で)〈場所・音・声が〉『反響する』《+『with』+『名』(do『ing』)》
シ(全音階の第7音)
時間の調節;時間を測定[記録]すること
…掛ける

UpToDate Contents

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1. 三次元心エコー検査 three dimensional echocardiography
2. 冬眠心筋の評価におけるドブタミン負荷心エコー検査 dobutamine stress echocardiography in the evaluation of hibernating myocardium
3. 左心室の評価における経食道心エコー transesophageal echocardiography in the evaluation of the left ventricle
4. 負荷心エコーの概要 overview of stress echocardiography
5. 組織ドップラー心エコー tissue doppler echocardiography

English Journal

Abnormal default-mode network homogeneity in first-episode, drug-naive schizophrenia at rest.

Guo W1, Yao D2, Jiang J2, Su Q2, Zhang Z2, Zhang J2, Yu L2, Xiao C2.Author information 1Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China. Electronic address: guowenbin76@163.com.2Mental Health Center, the First Affiliated Hospital, Guangxi Medical University, Nanning, Guangxi 530021, China.AbstractBACKGROUND: Dysconnectivity hypothesis posits that schizophrenia relates to abnormal resting-state connectivity within the default-mode network (DMN) and this aberrant connectivity is considered as contribution of difficulties in self-referential and introspective processing. However, little is known about the alterations of the network homogeneity (NH) of the DMN in schizophrenia. In the present study, we used an automatic NH method to investigate the NH of the DMN in schizophrenia patients at rest.
Progress in neuro-psychopharmacology & biological psychiatry.Prog Neuropsychopharmacol Biol Psychiatry.2014 Mar 3;49:16-20. doi: 10.1016/j.pnpbp.2013.10.021. Epub 2013 Nov 9.
BACKGROUND: Dysconnectivity hypothesis posits that schizophrenia relates to abnormal resting-state connectivity within the default-mode network (DMN) and this aberrant connectivity is considered as contribution of difficulties in self-referential and introspective processing. However, little is know
PMID 24216538

Dexamethasone exacerbates cerebral edema and brain injury following lithium-pilocarpine induced status epilepticus.

Duffy BA1, Chun KP2, Ma D3, Lythgoe MF4, Scott RC5.Author information 1Centre for Advanced Biomedical Imaging (CABI), Department of Medicine, University College London (UCL), UK. Electronic address: ben.duffy.09@ucl.ac.uk.2School of Environment and Sustainability, University of Saskatchewan, Canada.3Centre for Advanced Biomedical Imaging (CABI), Department of Medicine, University College London (UCL), UK; Centre for Medical Image Computing (CMIC), University College London (UCL), UK.4Centre for Advanced Biomedical Imaging (CABI), Department of Medicine, University College London (UCL), UK. Electronic address: m.lythgoe@ucl.ac.uk.5Department of Neurological Sciences, College of Medicine, University of Vermont, Burlington 05405, VT, USA; UCL Institute of Child Health, University College London, London, UK.AbstractAnti-inflammatory therapies are the current most plausible drug candidates for anti-epileptogenesis and neuroprotection following prolonged seizures. Given that vasogenic edema is widely considered to be detrimental for outcome following status epilepticus, the anti-inflammatory agent dexamethasone is sometimes used in clinic for alleviating cerebral edema. In this study we perform longitudinal magnetic resonance imaging in order to assess the contribution of dexamethasone on cerebral edema and subsequent neuroprotection following status epilepticus. Lithium-pilocarpine was used to induce status epilepticus in rats. Following status epilepticus, rats were either post-treated with saline or with dexamethasone sodium phosphate (10mg/kg or 2mg/kg). Brain edema was assessed by means of magnetic resonance imaging (T2 relaxometry) and hippocampal volumetry was used as a marker of neuronal injury. T2 relaxometry was performed prior to, 48h and 96h following status epilepticus. Volume measurements were performed between 18 and 21days after status epilepticus. Unexpectedly, cerebral edema was worse in rats that were treated with dexamethasone compared to controls. Furthermore, dexamethasone treated rats had lower hippocampal volumes compared to controls 3weeks after the initial insult. The T2 measurements at 2days and 4days in the hippocampus correlated with hippocampal volumes at 3weeks. Finally, the mortality rate in the first week following status epilepticus increased from 14% in untreated rats to 33% and 46% in rats treated with 2mg/kg and 10mg/kg dexamethasone respectively. These findings suggest that dexamethasone can exacerbate the acute cerebral edema and brain injury associated with status epilepticus.
Neurobiology of disease.Neurobiol Dis.2014 Mar;63:229-36. doi: 10.1016/j.nbd.2013.12.001. Epub 2013 Dec 12.
Anti-inflammatory therapies are the current most plausible drug candidates for anti-epileptogenesis and neuroprotection following prolonged seizures. Given that vasogenic edema is widely considered to be detrimental for outcome following status epilepticus, the anti-inflammatory agent dexamethasone
PMID 24333865

Longitudinal assessment of blood-brain barrier leakage during epileptogenesis in rats. A quantitative MRI study.

van Vliet EA1, Otte WM2, Gorter JA3, Dijkhuizen RM4, Wadman WJ3.Author information 1Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; Epilepsy Institute in The Netherlands Foundation (Stichting Epilepsie Instellingen Nederland, SEIN), Heemstede, The Netherlands. Electronic address: e.a.vanvliet@uva.nl.2Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands; Department of Pediatric Neurology, Rudolf Magnus Institute of Neuroscience, University medical Center Utrecht, Utrecht, The Netherlands.3Center for Neuroscience, Swammerdam Institute for Life Sciences, University of Amsterdam, Amsterdam, The Netherlands; Epilepsy Institute in The Netherlands Foundation (Stichting Epilepsie Instellingen Nederland, SEIN), Heemstede, The Netherlands.4Biomedical MR Imaging and Spectroscopy Group, Image Sciences Institute, University Medical Center Utrecht, Utrecht, The Netherlands.AbstractThe blood-brain barrier (BBB) plays an important role in the homeostasis of the brain. BBB dysfunction has been implicated in the pathophysiology of various neurological disorders, including epilepsy in which it may contribute to disease progression. Precise understanding of BBB dynamics during epileptogenesis may be of importance for the assessment of future therapies, including BBB leakage blocking-agents. Longitudinal changes in BBB integrity can be studied with in vivo magnetic resonance imaging (MRI) in combination with paramagnetic contrast agents. Although this approach has shown to be suitable to detect major BBB leakage during the acute phase in experimental epilepsy models, so far no studies have provided information on dynamics of the extent of BBB leakage towards later phases. Therefore a sensitive and quantitative approach was used in the present study, involving fast T1 mapping (dynamic approach) during a steady-state infusion of gadobutrol, as well as pre- and post-contrast T1-weighted MRI (post-pre approach). This was applied in an experimental epilepsy model in which previous MRI studies failed to detect BBB leakage during epileptogenesis. Adult male Sprague-Dawley rats were injected with kainic acid to induce status epilepticus (SE). MRI experiments were performed before SE (control) and during the acute (1day) and chronic epileptic phases (6weeks after SE). BBB leakage was quantified by fast T1 mapping (Look-Locker gradient echo MRI) with a time resolution of 48s from 5min before up to 45min after 20min step-down infusion of 0.2M gadobutrol. In addition, T1-weighted MRI was acquired before and 45min after infusion. MRI data were compared to post-mortem microscopic analysis using the BBB tracer fluorescein. Our MRI data showed BBB leakage, which was evident at 1day and 6weeks after SE in the hippocampus, entorhinal cortex, amygdala and piriform cortex. These findings were confirmed by microscopic analysis of fluorescein leakage. Furthermore, our MRI data revealed non-uniform BBB leakage throughout epileptogenesis. This study demonstrates BBB leakage in specific brain regions during epileptogenesis, which can be quantified using MRI. Therefore, MRI may be a valuable tool for experimental or clinical studies to elucidate the role of the BBB in epileptogenesis.
Neurobiology of disease.Neurobiol Dis.2014 Mar;63:74-84. doi: 10.1016/j.nbd.2013.11.019. Epub 2013 Dec 7.
The blood-brain barrier (BBB) plays an important role in the homeostasis of the brain. BBB dysfunction has been implicated in the pathophysiology of various neurological disorders, including epilepsy in which it may contribute to disease progression. Precise understanding of BBB dynamics during epil
PMID 24321435

Japanese Journal

PSO Based Deterministic ESN Models for Stock Price Forecasting

Dan Jingpei,Guo Wenbo,Shi Weiren [他]
Journal of advanced computational intelligence and intelligent informatics 19(2), 312-318, 2015-03
NAID 40020443970

The Technical and Clinical Features of 3D-FLAIR in Neuroimaging

Magnetic Resonance in Medical Sciences 14(2), 93-106, 2015
… In clinical MR neuroimaging, 3D fluid-attenuated inversion recovery (3D-FLAIR) with a variable-flip-angle turbo spin echo sequence is becoming popular. … In addition, 3D-FLAIR can be obtained within a clinically reasonable scan time. …
NAID 130005069923

鈍的多発外傷に合併した胆石を伴う胆囊破裂の1例

野坂涼子,山野修平,猪熊孝実,泉野浩生,井上悠介,三島壯太,虎島泰洋,藤田文彦,金高賢悟,高槻光寿,黒木保,江口晋,田崎修
日本腹部救急医学会雑誌 35(1), 115-118, 2015
… 来院時ショック状態でFASTではMorrison窩・脾周囲にecho free spaceを認めた。 … CT検査後，FASTでecho free spaceの増大を認め，CTで肝損傷と門脈損傷の疑いもあったため緊急開腹手術を施行した。 …
NAID 130005069703

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