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TRAIL-Induced Caspase Activation Is a Prerequisite for Activation of the Endoplasmic Reticulum Stress-Induced Signal Transduction Pathways.

Lee DH1,2, Sung KS3,4, Guo ZS1, Kwon WT1, Bartlett DL1, Oh SC2, Kwon YT4, Lee YJ1,5.
Journal of cellular biochemistry.J Cell Biochem.2016 May;117(5):1078-91. doi: 10.1002/jcb.25289. Epub 2016 Feb 5.
It is well known that tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-induced apoptosis can be initially triggered by surface death receptors (the extrinsic pathway) and subsequently amplified through mitochondrial dysfunction (the intrinsic pathway). However, little is known about s
PMID 26212606

Repression of the eIF2α kinase PERK alleviates mGluR-LTD impairments in a mouse model of Alzheimer's disease.

Yang W1, Zhou X1, Zimmermann HR1, Cavener DR2, Klann E3, Ma T4.
Neurobiology of aging.Neurobiol Aging.2016 May;41:19-24. doi: 10.1016/j.neurobiolaging.2016.02.005. Epub 2016 Feb 13.
Mounting evidence indicates that impairments of synaptic efficacy and/or plasticity may be a key step in the development of Alzheimer's disease (AD) pathophysiology. Among the 2 major forms of synaptic plasticity, long-term potentiation and long-term depression (LTD), much less is known about how LT
PMID 27103515

Downregulation of protein kinase PKR activation by porcine reproductive and respiratory syndrome virus at its early stage infection.

Xiao Y1, Ma Z2, Wang R2, Yang L2, Nan Y2, Zhang YJ3.
Veterinary microbiology.Vet Microbiol.2016 May 1;187:1-7. doi: 10.1016/j.vetmic.2016.03.004. Epub 2016 Mar 7.
The interferon-induced double-strand RNA activated protein kinase (PKR) plays an important role in antiviral response. The objective of this study was to assess the effect of porcine reproductive and respiratory syndrome virus (PRRSV) on PKR activation. Here we report that PRRSV inhibited PKR activa
PMID 27066702

Methylglyoxal activates Gcn2 to phosphorylate eIF2α independently of the TOR pathway in Saccharomyces cerevisiae.

Nomura Wataru,Maeta Kazuhiro,Kita Keiko,Izawa Shingo,Inoue Yoshiharu
Applied microbiology and biotechnology 86(6), 1887-1894, 2010-05
… Previously, we have reported that methylglyoxal attenuates the rate of overall protein synthesis in Saccharomyces cerevisiae through phosphorylation of the alpha subunit of translation initiation factor 2 (eIF2alpha) in a Gcn2-dependent manner. … Phosphorylation of eIF2alpha impedes the formation of a translation initiation complex, and subsequently, overall protein synthesis is reduced. …
NAID 120002383972