WordNet
- intend (something) to move towards a certain goal; "He aimed his fists towards his opponents face"; "criticism directed at her superior"; "direct your anger towards others, not towards yourself" (同)aim, place, direct, point
- sports equipment consisting of an object set up for a marksman or archer to aim at (同)butt
- a reference point to shoot at; "his arrow hit the mark" (同)mark
- the location of the target that is to be hit (同)target area
- in the direction of a streams current
PrepTutorEJDIC
- (鉄砲などの)『標的』,的,攻撃目標 / (批評・軽べつなどの)的,種《+of+名》 / (行為などの)目標,到達目標
- 流れを下って,下流に / 下流の,川下の
UpToDate Contents
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- 1. 進行腎明細胞癌または転移性腎明細胞癌に対する抗血管新生療法および分子標的療法 anti angiogenic and molecularly targeted therapy for advanced or metastatic clear cell renal cell carcinoma
- 2. 成人における肝移植：免疫抑制の概要 liver transplantation in adults overview of immunosuppression
- 3. 臨床腫瘍学における遺伝子発現プロファイリング、プロテオミクス、およびマイクロRNAプロファイリングの概要 overview of gene expression profiling proteomics and microrna profiling in clinical oncology
- 4. 棘状細胞（棘状赤血球および有棘赤血球）と標的細胞の原因 causes of spiculated cells echinocytes and acanthocytes and target cells
- 5. 慢性腎疾患における貧血：エリスロポエチン製剤を投与した患者でのヘモグロビン／ヘマトクリットの目標値 anemia of chronic kidney disease target hemoglobin hematocrit for patients treated with erythropoietic agents
English Journal
- Impact of electrode sequence on electrochemical removal of trichloroethylene from aqueous solution.
- Rajic L1, Fallahpour N1, Alshawabkeh AN1.
- Applied catalysis. B, Environmental.Appl Catal B.2015 Sep 1;174-175:427-434.
- The electrode sequence in a mixed flow-through electrochemical cell is evaluated to improve the hydrodechlorination (HDC) of trichloroethylene (TCE) in aqueous solutions. In a mixed (undivided) electrochemical cell, oxygen generated at the anode competes with the transformation of target contaminant
- PMID 25931774
- Antibody targeting of HER2/HER3 signaling overcomes heregulin-induced resistance to PI3K inhibition in prostate cancer.
- Poovassery JS1, Kang JC2, Kim D2,3, Ober RJ2,3, Ward ES1,2,4.
- International journal of cancer. Journal international du cancer.Int J Cancer.2015 Jul 15;137(2):267-77. doi: 10.1002/ijc.29378. Epub 2014 Dec 19.
- Dysregulated expression and/or mutations of the various components of the phosphoinositide 3-kinase (PI3K)/Akt pathway occur with high frequency in prostate cancer and are associated with the development and progression of castration resistant tumors. However, small molecule kinase inhibitors that t
- PMID 25471734
- Characterisation of the adiponectin receptors: Differential cell-surface expression and temporal signalling profiles of AdipoR1 and AdipoR2 are regulated by the non-conserved N-terminal trunks.
- Keshvari S1, Whitehead JP2.
- Molecular and cellular endocrinology.Mol Cell Endocrinol.2015 Jul 5;409:121-9. doi: 10.1016/j.mce.2015.04.003. Epub 2015 Apr 16.
- The adiponectin axis regulates cardiometabolic and inflammatory tone making it an attractive therapeutic focus. Rudimentary understanding of the adiponectin receptors, AdipoR1 and AdipoR2, constrains our ability to target these atypical seven trans-membrane proteins. Here, we aimed to further elabor
- PMID 25892445
Japanese Journal
- A Novel Nrf2-Mediated Antioxidative and Antiinflammatory Mechanism through Ferroportin 1 Induction : A Potential Cytoprotective Mechanism against Ischemia-Reperfusion Injuries
- Harada Nobuhiko,Matsuura Shin,Kanayama Masaya,Yoshida Aruto,Itoh Ken
- 弘前医学 64(Supplement), S74-S80, 2013-04-02
- … To further clarify the mechanisms that act downstream of Nrf2, we performed microarray analysis in the RAW264.7 murine macrophage cell line using endogenous electrophilic prostaglandin 15-deoxy-Δ12,14-prostagrandin J2 （15d-PGJ2）. … As a result, we identified ferroportin 1 （Fpn1） as a novel Nrf2 target gene. …
- NAID 120005230055
- Ligand-triggered resistance to molecular targeted drugs in lung cancer: Roles of hepatocyte growth factor and epidermal growth factor receptor ligands
- Yano Seiji,Takeuchi Shinji,Nakagawa Takayuki,Yamada Tadaaki
- Cancer Science 103(7), 1189-1194, 2012-07-00
- … Known major mechanisms for resistance to molecular targeted drugs include gatekeeper mutations in the target gene and activation of bypass survival signal via receptors other than the target receptors. … For example, hepatocyte growth factor (HGF), the ligand of a tyrosine kinase receptor Met, activates Met and the downstream PI3K/Akt pathway and triggers resistance to EGFR inhibitors in EGFR mutant lung cancer cells. …
- NAID 120004140852
- Aberrant activation of the mTOR pathway and anti-tumour effect of everolimus on oesophageal squamous cell carcinoma
- Hirashima Kotaro,Baba Yoshifumi,Watanabe Masayuki,Karashima Ryu-ichi,Sato Nobutaka,Imamura Yu,Nagai Yohei,Hayashi Naoko,Iyama Ken-ichi,Baba Hideo,ヒラシマ コウタロウ,ババ ヨシフミ,ワタナベ マサユキ,カラシマ リュウイチ,サトウ ノブタカ,イマムラ ユウ,ナガイ ヨウヘイ,ハヤシ ナオコ,イヤマ ケンイチ,ババ ヒデオ,平島 浩太郎,馬場 祥史,渡邊 雅之,辛島 龍一,佐藤 伸隆,今村 裕,長井 洋平,林 尚子,猪山 賢一,馬場 秀夫
- British Journal of Cancer 106(5), 876-882, 2012-02-28
- … Background: The mammalian target of rapamycin (mTOR) protein is important for cellular growth and homeostasis. … Mammalian target of rapamycin inhibitors, such as everolimus (RAD001), are in development and show promise as anti-cancer drugs; …
- NAID 120005148224
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- Abstract Temporal expression profiling was utilized to define transcriptional regulatory pathways in vivo in a mouse muscle regeneration model. Potential downstream targets of MyoD were identified by temporal expression ...
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★リンクテーブル★
| リンク元 | 「下流因子」「下流標的」「下流ターゲット」「downstream factor」 |
| 関連記事 | 「target」「targeting」 |
「下流因子」
「下流標的」
「下流ターゲット」
「downstream factor」
「target」
- n.
- v.