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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/07/15 08:05:53」(JST)

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English Journal

Preparation and properties of a pH sensitive carrier based on three kinds of polymer blend to control the release of 5-amino salicylic acid.

Dong Y, Zhou Z, Ding H, Zhang S.Author information Jiangsu Provincial Key Laboratory for Interventional Medical Devices, Huaiyin Institute of Technology , Huaian, Jiangsu Province , P.R. China .AbstractAbstract Context: High concentration of 5-amino salicylic acid (5-ASA) in the distal ileum and colon is necessary for the treatment of inflammatory bowel disease (IBD). The control of small molecules, drugs, released from a polymeric matrix remains a great challenge. Objective: To study the preparation and properties of a pH-sensitive carrier for targeting delivery of 5-ASA. Materials and methods: The carrier was prepared by ternary blends method based on polyvinyl alcohol (PVA), sodium alginate (SA) and polylactic acid. It was characterized by infrared spectrometry and scanning electronic microscopy. The adsorption and release of 5-ASA in different pH media were investigated. Results: We found out the best ratio of the materials for synthetic carrier. The vector exhibited good performance by the controlled release of the target drug experiment. The adsorption capacity of the carrier for 5-ASA was 70.34% in phosphate buffer saline at pH 1.00, and the release rate was 100.49% in phosphate buffer solution at pH 6.80. Discussion and conclusion: PVA is vector backbone of the carrier, and SA plays key role in its pH performance. It is a promising material to effectively deliver 5-ASA to the specific sites of IBD.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Dec;19(8):960-7. doi: 10.3109/10837450.2013.846372.
Abstract Context: High concentration of 5-amino salicylic acid (5-ASA) in the distal ileum and colon is necessary for the treatment of inflammatory bowel disease (IBD). The control of small molecules, drugs, released from a polymeric matrix remains a great challenge. Objective: To study the preparat
PMID 24320757

Evidence and uptake routes for Zinc oxide nanoparticles through the gastrointestinal barrier in Xenopus laevis.

Bacchetta R, Moschini E, Santo N, Fascio U, Del Giacco L, Freddi S, Camatini M, Mantecca P.Author information Department of Biosciences, Università degli Studi di Milano , Milano , Italy.AbstractAbstract The developmental toxicity of nanostructured materials, as well as their impact on the biological barriers, represents a crucial aspect to be assessed in a nanosafety policy framework. Nanosized metal oxides have been demonstrated to affect Xenopus laevis embryonic development, with nZnO specifically targeting the digestive system. To study the mechanisms of the nZnO-induced intestinal lesions, we tested two different nominally sized ZnO nanoparticles (NPs) at effective concentrations. Advanced microscopy techniques and molecular marker analyses were applied in order to describe the NP-epithelial cell interactions and the mechanisms driving NP toxicity and translocation through the intestinal barrier. We attributed the toxicity to NP-induced cell oxidative damage, the small-sized NPs being the more effective. This outcome is sustained by a marked increase in anti-oxidant genes' expression and high lipid peroxidation level in the enterocytes, where disarrangement of the cytoskeleton and cell junctions' integrity were evidenced. These events led to diffuse necrotic changes in the intestinal barrier, and trans- and paracellular NP permeation through the mucosa. The uptake routes, leading NPs to cross the intestinal barrier and reach secondary target tissues, have been documented. nZnOs embryotoxicity was confirmed to be crucially mediated by the NPs' reactivity rather than their dissolved ions. The ZnO NPs' ability to overwhelm the intestinal barrier must be taken into high consideration for a future design of safer ZnO NPs.
Nanotoxicology.Nanotoxicology.2014 Nov;8:728-44. doi: 10.3109/17435390.2013.824128. Epub 2013 Aug 6.
Abstract The developmental toxicity of nanostructured materials, as well as their impact on the biological barriers, represents a crucial aspect to be assessed in a nanosafety policy framework. Nanosized metal oxides have been demonstrated to affect Xenopus laevis embryonic development, with nZnO sp
PMID 23848496

Calculating osmotic pressure of xylitol solutions from molality according to UNIFAC model and measuring it with air humidity osmometry.

Yu L, Zhan T, Zhan X, Wei G, Tan X, Wang X, Li C.Author information Key Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University , Chengdu, Sichuan , PR China and.AbstractAbstract The osmotic pressure of xylitol solution at a wide concentration range was calculated according to the UNIFAC model and experimentally determined by our newly reported air humidity osmometry. The measurements from air humidity osmometry were compared with UNIFAC model calculations from dilute to saturated solution. Results indicate that air humidity osmometry measurements are comparable to UNIFAC model calculations at a wide concentration range by two one-sided test and multiple testing corrections. The air humidity osmometry is applicable to measure the osmotic pressure and the osmotic pressure can be calculated from the concentration.
Pharmaceutical development and technology.Pharm Dev Technol.2014 Nov;19(7):853-5. doi: 10.3109/10837450.2013.836221. Epub 2013 Sep 13.
Abstract The osmotic pressure of xylitol solution at a wide concentration range was calculated according to the UNIFAC model and experimentally determined by our newly reported air humidity osmometry. The measurements from air humidity osmometry were compared with UNIFAC model calculations from dilu
PMID 24032449