- 日
- 関
WordNet
- any of the salts of hydrobromic acid; formerly used as a sedative but now generally replaced by safer drugs
PrepTutorEJDIC
- 〈U〉臭化物(鎮静剤・睡眠剤として用いる) / 〈C〉《話》陳腐なことば
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2013/11/16 02:38:24」(JST)
[Wiki en表示]
Domiphen bromide
|
Systematic (IUPAC) name |
N,N-dimethyl-N-(2-phenoxyethyl)dodecan-1-aminium bromide |
Clinical data |
AHFS/Drugs.com |
International Drug Names |
Pregnancy cat. |
? |
Legal status |
? |
Identifiers |
CAS number |
538-71-6 Y |
ATC code |
A01AB06 |
PubChem |
CID 10866 |
ChemSpider |
10406 Y |
UNII |
R4CY19YS7C Y |
KEGG |
D01588 Y |
ChEMBL |
CHEMBL486696 Y |
Chemical data |
Formula |
C22H40BrNO |
Mol. mass |
414.463 g/mol |
SMILES
- [Br-].O(c1ccccc1)CC[N+](CCCCCCCCCCCC)(C)C
|
InChI
-
InChI=1S/C22H40NO.BrH/c1-4-5-6-7-8-9-10-11-12-16-19-23(2,3)20-21-24-22-17-14-13-15-18-22;/h13-15,17-18H,4-12,16,19-21H2,1-3H3;1H/q+1;/p-1 Y
Key:OJIYIVCMRYCWSE-UHFFFAOYSA-M Y
|
Y (what is this?) (verify)
|
Domiphen bromide is a chemical antiseptic and a quaternary ammonium compound.[1]
References[edit]
- ^ Active ingredients used in cosmetics: safety survey (2008). Council of Europe. 2008. p. 97. ISBN 978-92-871-6298-4.
Stomatological preparations (A01)
|
|
Caries
prophylactic
agents |
- Dectaflur
- Olaflur
- Sodium fluoride
- Sodium monofluorophosphate
- Stannous fluoride
|
|
Anti-infectives
and antiseptics |
- Amphotericin B
- Benzoxonium chloride
- Chlorhexidine
- Chlortetracycline
- Clotrimazole
- Domiphen bromide
- Doxycycline
- Eugenol
- Hexetidine
- Hydrogen peroxide
- Mepartricin
- Metronidazole
- Miconazole
- Minocycline
- Natamycin
- Neomycin
- Oxyquinoline
- Polynoxylin
- Sodium perborate
- Tetracycline
- Tibezonium iodide
|
|
Corticosteroids
(Glucocorticoids) |
- Dexamethasone
- Hydrocortisone
- Triamcinolone
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Other |
- Amlexanox
- Acetylsalicylic acid
- Becaplermin
- Benzydamine
- Epinephrine/Adrenalone
|
|
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noco/cofa (c)/cogi/tumr, sysi
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UpToDate Contents
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English Journal
- Stressed degradation studies of domiphen bromide by LC-ESI-MS/MS identify a novel promising antimicrobial agent.
- Fumagalli L, Regazzoni LG, Straniero V, Valoti E, Aldini G, Vistoli G, Carini M, Picozzi C.
- Journal of pharmaceutical and biomedical analysis. 2018 Sep;159()224-228.
- Nowadays, parabens have been replaced by domiphen bromide, which is widely used in pharmaceutical and cosmetic products. The main aim of this study was to investigate stressed degradation products of domiphen bromide by mean of a rapid, specific and reliable LC-ESI MS/MS since phenyl bromination may
- PMID 29990889
- Data on thermal and hydrolytic stability of both domiphen bromide and para-bromodomiphen bromide.
- Fumagalli L, Moretto A, Gilardoni E, Picozzi C, Vistoli G, Carini M.
- Data in brief. 2018 Oct;20()1363-1366.
- In this data article, HPLC analyses were applied to investigate the hydrolytic and thermal stability of domiphen bromide a FDA approved OTC ingredients endowed with antimicrobial activity. The data obtained by stressing domiphen bromide in acid, base and thermal conditions enlarge the research artic
- PMID 30246118
- HPLC method for identification and quantification of three active substances in a dermatological preparation--Viosept ointment.
- Podolska M, Kulik A, Białecka W, Kwiatkowska-Puchniarz B, Mazurek A.
- Acta poloniae pharmaceutica. ;71(5)709-19.
- The study was aimed at developing a HPLC method to identify and quantify domiphen bromide, tripelennamine hydrochloride and clioquinol in Viosept ointment. The tested substances were successfully separated using Inertsil ODS-3 (250 x 4.6 mm, 5 μm) as a stationary phase and a gradient elution. Detec
- PMID 25362799
Japanese Journal
- Streptococcus sobrinus 6715株接種ラットにおける塩化デカリニウムおよび臭化ドミフェンのう蝕抑制効果
- う蝕病原菌の非水溶性グルカン合成に対する第4級アンモニウム塩類の抑制効果
- アズノール・キシロカイン・オラドール含嗽液(OAKG)の安定性に関する研究
- 佐藤 悦子,山田 礼子,多田 均,鈴木 敏夫,海野 勝男
- 病院薬学 19(3), 196-202, 1993-06-21
- … Mixing of azunol, xylocain and oradol gargle (OAKG) resulted in the formation of the precipitate which was characterized as the salt of azulene sulfonic acid and domiphen based on its IR and ^<1->H-NMR spectrum. … The concentration of sodium azulene sulfonate (SAS) and domiphen bromide in the preparation of OAKG is reduced by forming precipitates. …
- NAID 110001798939
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