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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/05/22 02:28:57」(JST)

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Difluprednate is a corticosteroid, It is chemically a butyrate ester of 6(alpha),9(alpha)-difluoro prednisolone acetate. Accordingly, difluprednate is sometimes abbreviated DFBA, for difluoroprednisolone butyrate acetate.

Approval

On June 24, 2008, the US Food and Drug Administration (FDA) approved difluprednate for the treatment of post-operative ocular inflammation and pain.^[1] It is marketed by Alcon under the tradename Durezol.

Clinical trials

Difluprednate ophthalmic emulsion 0.05% is also being studied in other ocular inflammatory diseases, including a U.S. Phase 3 study evaluating difluprednate for the treatment of anterior uveitis.^[2]

References

^ "Sirion Therapeutics Announces FDA Approval of Durezol for Treatment of Postoperative Ocular Inflammation and Pain" (Press release). Sirion Therapeutics, Inc. 2008-06-24. Retrieved 2008-06-30.
^ ClinicalTrials.gov

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1. ブドウ膜炎：治療 uveitis treatment
2. AIDS関連サイトメガロウイルス網膜炎の治療 treatment of aids related cytomegalovirus retinitis

English Journal

Bioavailability of generic 0.05% difluprednate emulsion in the aqueous humor, cornea, and conjunctiva of New Zealand rabbits after a single dose compared with commercial difluprednate.

Mercado-Sesma A1,2, Contreras-Rubio A3, Baiza-Durán L3, Olvera-Montaño O3, Miranda-Robles M3, Bonilla-García J3.
Journal of ophthalmic inflammation and infection.J Ophthalmic Inflamm Infect.2017 Dec;7(1):10. doi: 10.1186/s12348-017-0127-2. Epub 2017 Mar 21.
PMID 28324274

INCIDENCE OF ACUTE EXUDATIVE MACULOPATHY AFTER REDUCED-FLUENCE PHOTODYNAMIC THERAPY.

Mammo Z1, Forooghian F.
Retinal cases & brief reports.Retin Cases Brief Rep.2017 Summer;11(3):217-220. doi: 10.1097/ICB.0000000000000356.
PMID 27380223

Nonclinical Development of ENV905 (Difluprednate) Ophthalmic Implant for the Treatment of Inflammation and Pain Associated with Ocular Surgery.

Verhoeven RS1, Garcia A1, Robeson R1, Gilger BC2, Culp D2, Struble C3, Hamm L4, Navratil T1, Yerxa B1.
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics.J Ocul Pharmacol Ther.2017 Jun 26. doi: 10.1089/jop.2016.0195. [Epub ahead of print]
PMID 28650720

Japanese Journal

犬の前部ぶどう膜炎における0.05%ジフルプレドナート乳濁点眼液と0.1%ベタメタゾン配合点眼薬の有効性に関する調査

印牧信行,市川陽一朗,木下徹,住吉俊夫,浦野岩雄,田中一則,藤野和彦
動物臨床医学 = Journal of Animal Clinical Research Foundation 21(3), 103-108, 2012-10-20
NAID 10031129795

犬のブドウ膜炎に対する0.05%ジフルプレドナート点眼薬の治療効果

高島一昭,山形静夫,山根義久
動物臨床医学 = Journal of Animal Clinical Research Foundation 21(1), 12-17, 2012-03-31
NAID 10030539790

犬の外眼部炎症性疾患に対する0.05%ジフルプレドナート点眼薬の治療効果

高島一昭,山形静夫,山根義久
動物臨床医学 = Journal of Animal Clinical Research Foundation 20(3), 83-88, 2011-09-30
NAID 10029806714

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リンク元	「ジフルプレドナート」「epitopic」

「ジフルプレドナート」

Difluprednate
Systematic (IUPAC) name
	[(6S,8S,9R,10S,11S,13S,14S,17R)-17-(2-acetyloxyacetyl)-6,9-difluoro-11-hydroxy-10,13-dimethyl-3-oxo-6,7,8,11,12,14,15,16-octahydrocyclopenta[a]phenanthren-17-yl] butanoate
Clinical data
AHFS/Drugs.com	monograph
MedlinePlus	a609025
License	US FDA: Difluprednate;
Administration	topical dermatologic
Legal status
Legal status	US: ℞-only;
Identifiers
CASRN	23674-86-4
ATC code	D07AC19 (WHO)
PubChem	CID 32037
DrugBank	DB06781
ChemSpider	391990
UNII	S8A06QG2QE
KEGG	D01266
ChEMBL	CHEMBL1201749
Chemical data
Formula	C27H34F2O7
Molar mass	508.551
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