- 日
- 関
- 同
- Nupercainal
WordNet
- a local anesthetic that is administered by injection
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2017/11/26 05:41:40」(JST)
[Wiki en表示]
Cinchocaine
|
|
| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
topical, intravenous (for animal euthanasia) |
| ATC code |
- C05AD04 (WHO) D04AB02 (WHO) N01BB06 (WHO) S01HA06 (WHO) S02DA04 (WHO)
|
| Legal status |
| Legal status |
|
| Identifiers |
IUPAC name
- 2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
|
| CAS Number |
|
| PubChem CID |
|
| IUPHAR/BPS |
|
| DrugBank |
|
| ChemSpider |
|
| UNII |
|
| KEGG |
|
| ChEBI |
|
| ChEMBL |
|
| ECHA InfoCard |
100.001.484 |
| Chemical and physical data |
| Formula |
C20H29N3O2 |
| Molar mass |
343.463 g/mol |
| 3D model (JSmol) |
|
SMILES
-
O=C(c1c2ccccc2nc(OCCCC)c1)NCCN(CC)CC
|
InChI
-
InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) Y
-
Key:PUFQVTATUTYEAL-UHFFFAOYSA-N Y
|
| (verify) |
Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Contents
- 1 Medical use
- 2 Physical properties
- 3 See also
- 4 References
- 5 Further reading
Medical use
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties
Cinchocaine is relatively insoluble in alkaline aqueous solutions.
See also
References
- ^ Martindale, The Extra Pharmacopoeia, 30th ed, p1006
- ^ Dibucaine
Further reading
- Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry". Farmaco. 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- Souto-Padron T, Lima AP, de Oliveira Ribeiro R (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi". Parasitol Res. 99 (4): 317–20. doi:10.1007/s00436-006-0192-1. PMID 16612626.
- Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles". Acta Pol Pharm. 62 (5): 369–79. PMID 16459486.
- Aroti, A.; Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment". Journal of Chemical Education. 78 (6): 786–788. doi:10.1021/ed078p786.
|
Vasoprotectives (C05)
|
| Antihemorrhoidals for topical use |
| corticosteroids |
- Hydrocortisone
- Prednisolone
- Betamethasone
- Fluorometholone
- Fluocortolone
- Dexamethasone
- Fluocinolone acetonide
- Fluocinonide
|
| local anesthetics |
- Lidocaine
- Tetracaine
- Benzocaine
- Dibucaine
- Procaine
- Oxetacaine
- Pramocaine
|
| other |
|
|
| Antivaricose therapy |
| heparins or heparinoids for topical use |
- Organo-heparinoid
- Sodium apolate
- Heparin
- Pentosan polysulfate
|
| sclerosing agents for local injection |
- Monoethanolamine oleate
- Polidocanol
- Inverted sugar syrup
- Sodium tetradecyl sulfate
- Phenol
|
| other |
|
|
| Capillary stabilising agents |
| bioflavonoids |
- Rutoside
- Monoxerutin
- Diosmin
- Troxerutin
- Hidrosmin
|
| other |
|
|
|
Antipruritics (D04)
|
| Antihistamines for topical use |
- Thonzylamine
- Mepyramine
- Thenalidine
- Tripelennamine
- Chloropyramine
- Promethazine
- Tolpropamine
- Dimetindene
- Clemastine
- Bamipine
- Isothipendyl
- Diphenhydramine
- Chlorphenoxamine
|
| Anesthetics for topical use |
- Lidocaine
- Dibucaine
- Oxybuprocaine
- Benzocaine
- Quinisocaine
- Tetracaine
- Pramocaine
|
| Others |
- Corticosteroids (e.g., hydrocortisone)
- Counterirritants (e.g., mint oil, menthol, camphor)
- Nalfurafine
|
|
Local anesthetics (primarily sodium channel blockers) (N01B)
|
| Esters by acid |
| Aminobenzoic |
- Benzocaine
- Butacaine
- Butamben
- Chloroprocaine
- Dimethocaine
- Lucaine
- Meprylcaine
- Metabutethamine
- Metabutoxycaine
- Nitracaine
- Orthocaine
- Propoxycaine
- Procaine (Novocaine)
- Proxymetacaine
- Risocaine
- Tetracaine
|
| Benzoic |
- Amylocaine
- Cocaine
- Cyclomethycaine
- α-Eucaine
- β-Eucaine
- Hexylcaine
- Isobucaine
- Piperocaine
|
| ArCO2- (not para-amino or Ph) |
- Amoproxan (3,4,5-Trimethoxybenzoyl)
- 3-(p-Fluorobenzoyloxy)tropane
|
|
| Amides |
- Articaine
- Bupivacaine# / Levobupivacaine / Ropivacaine
- Butanilicaine
- Carticaine
- Dibucaine
- Etidocaine
- Lidocaine#
- Mepivacaine
- Prilocaine
- Trimecaine
|
| Combinations |
- Lidocaine / prilocaine
- Anesthetic / vasoconstrictor
- TAC
- Iontocaine
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Enhancement of the 1-Octanol/Water Partition Coefficient of the Anti-Inflammatory Indomethacin in the Presence of Lidocaine and Other Local Anesthetics.
- Tateuchi R1, Sagawa N1, Shimada Y1, Goto S1.
- The journal of physical chemistry. B.J Phys Chem B.2015 Jul 15. [Epub ahead of print]
- Side effects and excessive potentiation of drug efficacy caused by polypharmacy are becoming important social issues. The apparent partition coefficient of indomethacin (log P'IND) increases in the presence of lidocaine, and this is used as a physicochemical model for investigating polypharmacy. We
- PMID 26121007
- Paraquat Induces Cell Death Through Impairing Mitochondrial Membrane Permeability.
- Huang CL1,2, Chao CC3, Lee YC4, Lu MK5, Cheng JJ5,6, Yang YC7, Wang VC8,9, Chang WC10, Huang NK11,12,13.
- Molecular neurobiology.Mol Neurobiol.2015 May 7. [Epub ahead of print]
- Paraquat (PQ) as a Parkinsonian mimetic has been demonstrated to impair dopaminergic (DAergic) neurons and is highly correlated with the etiology of Parkinson's disease (PD) where the death of DAergic neurons has been mainly attributed to impaired mitochondrial functioning. In this study, PQ-induced
- PMID 25947082
- Determination of zolpidem in human plasma by liquid chromatography-tandem mass spectrometry for clinical application.
- Byeon JY1, Lee HI1, Lee YJ2, Lee JE1, Kim SH1, Kim YH1, Na HS3, Jang CG1, Lee SY4.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 Apr 1;986-987:129-34. doi: 10.1016/j.jchromb.2015.02.004. Epub 2015 Feb 9.
- Zolpidem (ZPD) is widely described for the short-term treatment of insomnia. We have developed and validated a simple and rapid liquid chromatography analytical method using tandem mass spectrometry (LC-MS/MS) for the quantification of ZPD in human plasma. Using dibucaine as an internal standard (IS
- PMID 25728370
Japanese Journal
- 臨床 腰痛症に対するジブカイン塩酸塩配合薬によるトリガーポイント注射の治療効果
- Simultaneous determination of dibucaine and naphazoline in human serum by monolithic silica spin column extraction and liquid chromatography-mass spectrometry
- SAITO Takeshi,MORITA Seiji,KISHIYAMA Izumi,MIYAZAKI Shota,NAKAMOTO Akihiro,NISHIDA Manami,NAMERA Akira,NAGAO Masataka,INOKUCHI Sadaki
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 872(1), 186-190, 2008-09-01
- NAID 10028006232
Related Links
- Dibucaine or cinchocaine is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of dibucaine is generally restricted to spinal and topical anesthesia.
Related Pictures
★リンクテーブル★
[★]
- 英
- dibucaine
- 化
- ジブカイン塩酸塩, 塩酸ジブカイン, dibucaine hydrochloride
- 商
- ペルカミンエス、ジカベリン、ジブカルソー、タイオゼット、トリガイン、ネオビタカイン、ネオペルカミン、ビーセルファ、プロクトセディル、プロネスパスタアロマ、ペリオドン、ペルカミン
- 関
- シンコカイン、局所麻酔薬
[★]
シンコカイン
- 関
- dibucaine
[★]
塩酸ジブカイン・塩酸パラブチルアミノ安息香酸ジエチルアミノエチル合剤
[★]
- 関
- dibucaine