シンコカイン
- 関
- dibucaine
WordNet
- a local anesthetic that is administered by injection
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/10/01 07:22:26」(JST)
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Cinchocaine
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| Systematic (IUPAC) name |
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2-butoxy-N-[2-(diethylamino)ethyl]quinoline-4-carboxamide
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| Clinical data |
| AHFS/Drugs.com |
International Drug Names |
| Legal status |
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Routes of
administration |
topical, intravenous (equine euthanasia) |
| Identifiers |
| CAS Registry Number |
85-79-0 Y |
| ATC code |
C05AD04 D04AB02 N01BB06 S01HA06 S02DA04 |
| PubChem |
CID: 3025 |
| IUPHAR/BPS |
7159 |
| DrugBank |
DB00527 Y |
| ChemSpider |
2917 Y |
| UNII |
L6JW2TJG99 Y |
| KEGG |
D00733 Y |
| ChEBI |
CHEBI:247956 Y |
| ChEMBL |
CHEMBL1086 Y |
| Chemical data |
| Formula |
C20H29N3O2 |
| Molecular mass |
343.463 g/mol |
SMILES
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O=C(c1c2ccccc2nc(OCCCC)c1)NCCN(CC)CC
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InChI
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InChI=1S/C20H29N3O2/c1-4-7-14-25-19-15-17(16-10-8-9-11-18(16)22-19)20(24)21-12-13-23(5-2)6-3/h8-11,15H,4-7,12-14H2,1-3H3,(H,21,24) Y
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Key:PUFQVTATUTYEAL-UHFFFAOYSA-N Y
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| Y (what is this?) (verify) |
Cinchocaine (INN/BAN) or dibucaine (USAN) is an amide local anesthetic. Among the most potent and toxic of the long-acting local anesthetics, current use of cinchocaine is generally restricted to spinal and topical anesthesia.[1][2] It is sold under the brand names Cincain, Nupercainal, Nupercaine and Sovcaine.
Contents
- 1 Medical use
- 2 Physical properties
- 3 See also
- 4 References
- 5 Further reading
Medical use
Cinchocaine is the active ingredient in some topical hemorrhoid creams such as Proctosedyl. It is also a component of the veterinary drug Somulose, used for euthanasia of horses and cattle.
Physical properties
Cinchocaine is relatively insoluble in alkaline aquatic solutions.
See also
References
- ^ Martindale, The Extra Pharmacopoeia, 30th ed, p1006
- ^ Dibucaine
Further reading
- Abdel-Ghani N, Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco 60 (5): 419–24. doi:10.1016/j.farmac.2005.03.001. PMID 15910814.
- Souto-Padron T, Lima AP, de Oliveira Ribeiro R. (2006). "Effects of dibucaine on the endocytic/exocytic pathways in Trypanosoma cruzi.". Parasitol Res 99 (4): 317–20. doi:10.1007/s00436-006-0192-1. PMID 16612626.
- Nounou M, El-Khordagui L, Khalafallah N (2005). "Effect of various formulation variables on the encapsulation and stability of dibucaine base in multilamellar vesicles.". Acta Pol Pharm 62 (5): 369–79. PMID 16459486.
- Aroti,A.;Leontidis, E. (2001). "Simultaneous Determination of the Ionization Constant and the Solubility of Sparingly Soluble Drug Substances. A Physical Chemistry Experiment .". Journal of Chemical Education 78 (6): 786–788. doi:10.1021/ed078p786.
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Vasoprotectives (C05)
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| Antihemorrhoidals for topical use |
| corticosteroids |
- Hydrocortisone
- Prednisolone
- Betamethasone
- Fluorometholone
- Fluocortolone
- Dexamethasone
- Fluocinolone acetonide
- Fluocinonide
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| local anesthetics |
- Lidocaine
- Tetracaine
- Benzocaine
- Dibucaine
- Procaine
- Oxetacaine
- Pramocaine
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| other |
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| Antivaricose therapy |
| heparins or heparinoids for topical use |
- Organo-heparinoid
- Sodium apolate
- Heparin
- Pentosan polysulfate
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| sclerosing agents for local injection |
- Monoethanolamine oleate
- Polidocanol
- Inverted sugar syrup
- Sodium tetradecyl sulfate
- Phenol
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| other |
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| Capillary stabilising agents |
| bioflavonoids |
- Rutoside
- Monoxerutin
- Diosmin
- Troxerutin
- Hidrosmin
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| other |
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Index of the circulatory system
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| Description |
- Anatomy
- Arteries
- head and neck
- arms
- chest
- abdomen
- legs
- Veins
- head and neck
- arms
- chest
- abdomen and pelvis
- legs
- Development
- Cells
- Physiology
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| Disease |
- Congenital
- Neoplasms and cancer
- Lymphatic vessels
- Injury
- Vasculitis
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Drugs
- beta blockers
- channel blockers
- diuretics
- nonsympatholytic vasodilatory antihypertensives
- peripheral vasodilators
- renin–angiotensin system
- sympatholytic antihypertensives
- vasoprotectives
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Antipruritics (D04)
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| Antihistamines for topical use |
- Thonzylamine
- Mepyramine
- Thenalidine
- Tripelennamine
- Chloropyramine
- Promethazine
- Tolpropamine
- Dimetindene
- Clemastine
- Bamipine
- Isothipendyl
- Diphenhydramine
- Chlorphenoxamine
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| Anesthetics for topical use |
- Lidocaine
- Dibucaine
- Oxybuprocaine
- Benzocaine
- Quinisocaine
- Tetracaine
- Pramocaine
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Index of skin
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| Description |
- Anatomy
- Physiology
- Development
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| Disease |
- Infections
- Vesiculobullous
- Dermatitis and eczema
- Papulosquamous
- Urticaria and erythema
- Radiation-related
- Pigmentation
- Mucinoses
- Keratosis, ulcer, atrophy, and necrobiosis
- Vasculitis
- Fat
- Neutrophilic and eosinophilic
- Congenital
- Neoplasms and cancer
- nevi and melanomas
- epidermis
- dermis
- Symptoms and signs
- Terminology
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| Treatment |
- Procedures
- Drugs
- antibiotics
- disinfectants
- emollients and protectives
- itch
- psoriasis
- other
- Wound and ulcer
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Local anesthetics (primarily sodium channel blockers) (N01B)
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| Esters by acid |
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Aminobenzoic
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- Benzocaine
- Butacaine
- Butamben
- Chloroprocaine
- Dimethocaine
- Lucaine
- Meprylcaine
- Metabutethamine
- Metabutoxycaine
- Orthocaine
- Propoxycaine
- Procaine (Novocaine)
- Proxymetacaine
- Risocaine
- Tetracaine
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Benzoic
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- Amylocaine
- 3-(p-Fluorobenzoyloxy)tropane
- Cocaine
- Cyclomethycaine
- α-Eucaine
- β-Eucaine
- Hexylcaine
- Isobucaine
- Piperocaine
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| Amides |
- Articaine
- Bupivacaine # / Levobupivacaine / Ropivacaine
- Butanilicaine
- Carticaine
- Dibucaine
- Etidocaine
- Lidocaine #
- Mepivacaine
- Prilocaine
- Trimecaine
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| Combinations |
- Lidocaine / prilocaine
- Anesthetic / vasoconstrictor
- Iontocaine
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- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
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Index of the peripheral nervous system
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| Description |
- Anatomy
- Nerves
- cranial
- trigeminal
- cervical
- brachial
- lumbosacral plexus
- somatosensory
- spinal
- autonomic
- Physiology
- reflexes
- proteins
- neurotransmitters
- transporters
- Development
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| Disease |
- Autonomic
- Congenital
- Injury
- Neoplasms and cancer
- Other
- Symptoms and signs
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| Treatment |
- Procedures
- Local anesthetics
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English Journal
- Interaction of local anesthetics with lipid bilayers investigated by (1)H MAS NMR spectroscopy.
- Weizenmann N, Huster D, Scheidt HA.SourceInstitute of Medical Physics and Biophysics, University of Leipzig, Härtelstr. 16-18, D-04107 Leipzig, Germany.
- Biochimica et biophysica acta.Biochim Biophys Acta.2012 Dec;1818(12):3010-8. doi: 10.1016/j.bbamem.2012.07.014. Epub 2012 Jul 25.
- The membrane location of the local anesthetics (LA) lidocaine, dibucaine, tetracaine, and procaine hydrochloride as well as their influence on phospholipid bilayers were studied by (31)P and (1)H magic-angle spinning (MAS) NMR spectroscopy. The (31)P NMR spectra of the LA/lipid preparations confirme
- PMID 22842001
- Contact allergy to local anaesthetics-value of patch testing with a caine mix in the baseline series.
- Brinca A, Cabral R, Gonçalo M.SourceDepartment of Dermatology, Coimbra University Hospital, 3000-075 Coimbra, Portugal.
- Contact dermatitis.Contact Dermatitis.2012 Jul 19. doi: 10.1111/j.1600-0536.2012.02149.x. [Epub ahead of print]
- Background Contact allergy to local anaesthetics is relatively common. Patch testing with benzocaine in the European baseline series is recommended for diagnosis, even though a caine mix has been previously suggested to be superior. Objectives To assess the frequency and patterns of contact allergy
- PMID 22812908
Japanese Journal
- Comparison of hyperbaric and plain bupivacaine with hyperbaric cinchocaine as spinal anaesthetic agents
- Cinchocaine and amethocaine inhibit activation and activity of superoxide production in human neutrophils
- Effects on the incidence of postoperative sore throat of 1 percent cinchocaine jelly for endotracheal intubation
Related Links
- Cinchocaine (or Dibucaine) is an amide local anesthetic. It is the active ingredient in some topical ... Youssef A, Awady M (2005). "Cinchocaine hydrochloride determination by atomic absorption spectrometry and spectrophotometry.". Farmaco ...
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