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AAC(3)-XI, a New Aminoglycoside 3-N-Acetyltransferase from Corynebacterium striatum.

Galimand M1, Fishovitz J2, Lambert T3, Barbe V4, Zajicek J2, Mobashery S5, Courvalin P6.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2015 Sep;59(9):5647-53. doi: 10.1128/AAC.01203-15. Epub 2015 Jul 6.
Corynebacterium striatum BM4687 was resistant to gentamicin and tobramycin but susceptible to kanamycin A and amikacin, a phenotype distinct among Gram-positive bacteria. Analysis of the entire genome of this strain did not detect any genes for known aminoglycoside resistance enzymes. Yet, annotatio
PMID 26149994

Synthesis and antibacterial activity of 1-N-[(S)-ω-amino-2-hydroxyalkyl] derivatives of dibekacin, 5-deoxydibekacin, 3'-deoxykanamycin A and gentamicin B.

Umemura E1, Sakamoto Y1, Takahashi Y1, Miyake T1.
The Journal of antibiotics.J Antibiot (Tokyo).2015 Jun;68(6):421-3. doi: 10.1038/ja.2015.6. Epub 2015 Feb 25.
PMID 25712399

Identification of a novel 6'-N-aminoglycoside acetyltransferase, AAC(6')-Iak, from a multidrug-resistant clinical isolate of Stenotrophomonas maltophilia.

Tada T1, Miyoshi-Akiyama T1, Dahal RK2, Mishra SK2, Shimada K1, Ohara H3, Kirikae T4, Pokhrel BM2.
Antimicrobial agents and chemotherapy.Antimicrob Agents Chemother.2014 Oct;58(10):6324-7. doi: 10.1128/AAC.03354-14. Epub 2014 Aug 4.
Stenotrophomonas maltophilia IOMTU250 has a novel 6'-N-aminoglycoside acetyltransferase-encoding gene, aac(6')-Iak. The encoded protein, AAC(6')-Iak, consists of 153 amino acids and has 86.3% identity to AAC(6')-Iz. Escherichia coli transformed with a plasmid containing aac(6')-Iak exhibited decreas
PMID 25092711

青木順子
日本医科大学雑誌 64(3), 232-237, 1997
… 1% of the cases, but 3 cases consulted us after more than six months.<BR>The determined allergens are noted in order of frequency as follows: 1) fradiomycin sulfate in 14 cases, 2) ketotifen fumarate in 6 cases, 3) dibekacin sulfate in 3 cases, 4) befunolol hydrochloride in 3 cases, 5) phenylephrine hydrochloride in 3 cases and 6) benzalkonium chloride, the preservative of eye drops in 3 cases. …
NAID 130003753326

鼻副鼻腔手術後の鎮痛効果を期待して試作したガーゼタンポン　（第２報）　タンポン素材に塗布する鎮痛剤含量および軟膏基剤の検討:タンポン素材に塗布する鎮痛剤含量および軟膏基剤の検討

菊池康隆,富谷義徳,矢部武,本多芳男,太田正治,蒲谷武郎,内田豊,並木徳之
耳鼻咽喉科展望 39(1), 77-82, 1996
先に我々は, 鼻副鼻腔手術の術後, 局所に挿入するタンポンを改良し鎮痛効果を付加した硫酸ジベカシンウフェナマートガーゼタンポン [DU-GT (1)] を試作し, その薬学的, 臨床的有効性について報告した。そして今回, より確実な鎮痛効果を得るためにウフェナマートを増量し, 軟膏基剤をプラスチベースに単一化したDU-GT (II) を作製した。そしてこれを鼻副鼻腔手術後に用いた場合の鎮痛効果につ …
NAID 130003974857