WordNet

(botany) a tiny outgrowth on the surface of a petal or leaf
a small nipple-shaped protuberance concerned with taste, touch, or smell; "the papillae of the tongue"
a small projection of tissue at the base of a hair or tooth or feather
of or relating to or located in the dermis (同)dermic

PrepTutorEJDIC

乳頭;(毛根・歯根などにある)微小乳頭状突起物
皮膚の,皮膚に関する
真皮(true skin),皮膚

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/11/14 13:10:02」(JST)

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In the human skin, the dermal papillae (DP) (singular papilla, diminutive of Latin papula, 'pimple') are small, nipple-like extensions (or interdigitations) of the dermis into the epidermis. At the surface of the skin in hands and feet, they appear as epidermal or papillary ridges (colloquially known as fingerprints).

Blood vessels in the dermal papillae nourish all hair follicles and bring nutrients and oxygen to the lower layers of epidermal cells. The pattern of ridges they produce in hands and feet are partly genetically determined features that develop before birth. They remain substantially unaltered (except in size) throughout life, and therefore determine the patterns of fingerprints, making them useful in certain functions of personal identification. ^[1]

The dermal papillae are part of the uppermost layer of the dermis, the papillary dermis, and the ridges they form greatly increase the surface area between the dermis and epidermis. Because the main function of the dermis is to support the epidermis, this greatly increases the exchange of oxygen, nutrients, and waste products between these two layers. Additionally, the increase in surface area prevents the dermal and epidermal layers from separating from each other by strengthening the junction between them. With age, the papillae tend to flatten and sometimes increase in number. ^[2]

Dermal papillae also play a pivotal role in hair formation, growth and cycling. ^[3]

In mucous membranes, the equivalent structures to dermal papillae are generally termed "connective tissue papillae", which interdigitate with the rete pegs of the superficial epithelium.

References

^ "Dermal papillae". Probert Encyclopaedia. Retrieved February 2010.
^ "Friction Skin". Ridges and Furrows. Retrieved February 2010.
^ Lin, Chang-min et al. (October 2008). "Microencapsulated human hair dermal papilla cells: a substitute for dermal papilla?". Archives of Dermatological Research (Springer) 300 (9): 531–535. doi:10.1007/s00403-008-0852-3.

External links

Anatomy photo: Integument/horn/horn3/horn4 - Comparative Organology at University of California, Davis - "Mammal, bovine horn (LM, Medium)"

UpToDate Contents

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1. 視神経の先天性および後天性異常 congenital anomalies and acquired abnormalities of the optic nerve
2. 新生児および乳児における皮膚および頭皮の良性病変 benign skin and scalp lesions in the newborn and young infant
3. 無駄毛の除毛 removal of unwanted hair
4. Bullous systemic lupus erythematosus
5. 男性における男性型脱毛症の治療 treatment of androgenetic alopecia in men

English Journal

Analysis of the microRNA expression profile of normal human dermal papilla cells treated with 5α-dihydrotestosterone.

Lee MJ1, Cha HJ1, Lim KM1, Lee OK1, Bae S1, Kim CH2, Lee KH2, Lee YN3, Ahn KJ3, An S1.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):1205-12. doi: 10.3892/mmr.2015.3478. Epub 2015 Mar 12.
Clinical evidence has demonstrated that the accumulation of 5α‑dihydrotestosterone (DHT) in dermal papilla cells (DPCs) is implicated in androgenetic alopecia. Whether this accumulation in DHT may have direct cellular effects leading to androgenetic alopecia remains to be elucidated. The present
PMID 25778683

Implication of microRNA regulation in para-phenylenediamine-induced cell death and senescence in normal human hair dermal papilla cells.

Lee OK1, Cha HJ1, Lee MJ1, Lim KM1, Jung JW2, Ahn KJ2, An IS1, An S1, Bae S1.
Molecular medicine reports.Mol Med Rep.2015 Jul;12(1):921-36. doi: 10.3892/mmr.2015.3487. Epub 2015 Mar 13.
Para-phenylenediamine (PPD) is a major component of hair coloring and black henna products. Although it has been largely demonstrated that PPD induces allergic reactions and increases the risk of tumors in the kidney, liver, thyroid gland and urinary bladder, the effect on dermal papilla cells remai
PMID 25776079

Effects of dihydrotestosterone on rat dermal papilla cells in vitro.

Kang JI1, Kim SC1, Kim MK1, Boo HJ1, Kim EJ1, Im GJ2, Kim YH3, Hyun JW4, Kang JH5, Koh YS6, Park DB7, Yoo ES1, Kang HK8.
European journal of pharmacology.Eur J Pharmacol.2015 Jun 15;757:74-83. doi: 10.1016/j.ejphar.2015.03.055. Epub 2015 Mar 30.
Androgenetic alopecia involves the action of dihydrotestosterone (DHT) on dermal papilla cells (DPCs) that line the base of the hair follicle. However, the mechanism of DHT action is not completely understood. The effects of DHT on DPCs, regulatory cells that function in follicle growth and the hair
PMID 25838072

Japanese Journal

Feather regeneration as a model for organogenesis

Lin Sung-Jan,Wideliz Randall B.,Yue Zhicao [他]
Development, growth & differentiation 55(1), 139-148, 2013-01-00
NAID 40019549303

幹細胞技術を用いた化粧品成分の開発と応用 : 植物成分を中心に (特集最近の植物系原料の開発と応用)

加藤智彦
Fragrance journal 40(7), 36-40, 2012-07-00
NAID 40019387618

アルガン幹細胞エキスの真皮・皮下組織に与える再生効果について (特集化粧品の新原料の開発動向を探る)

加藤智彦,Montano Irene
Fragrance journal 40(4), 17-19, 2012-04-00
NAID 40019275800

Related Pictures

★リンクテーブル★

リンク元	「真皮乳頭」
拡張検索	「dermal papilla cell」
関連記事	「dermal」「papilla」

「真皮乳頭」

Dermal papillae
	Dermal papilla labeled at top
	Papilla of the hand, treated with acetic acid. Magnified 350 times.; ; A. Side view of a papilla of the hand.; a. Cortical layer.; b. Tactile corpuscle.; c. Small nerve of the papilla, with neurolemma.; d. Its two nervous fibers running in spiral coils around the tactile corpuscle.; e. Apparent termination of one of these fibers.; ; B. Tactile papilla seen from above so as to show its transverse section.; a. Cortical layer.; b. Nerve fiber.; c. Outer layer of the tactile body, with nuclei.; d. Clear interior substance.
Details
Latin	papillae dermis
Identifiers
Dorlands; /Elsevier	p_03/12610332
TH	H3.12.00.1.03003
FMA	70737
	Anatomical terminology