de novo

• 新規の、新規に

関

anew、newly、novel

WordNet

1. pleasantly new or different; "common sense of a most refreshing sort" (同)refreshing
2. a printed and bound book that is an extended work of fiction; "his bookcases were filled with nothing but novels"; "he burned all the novels"
3. an extended fictional work in prose; usually in the form of a story
4. very recently; "they are newly married"; "newly raised objections"; "a newly arranged hairdo"; "grass new washed by the rain"; "a freshly cleaned floor"; "we are fresh out of tomatoes" (同)freshly, fresh, new
5. used to express refusal or denial or disagreement etc or especially to emphasize a negative statement; "no, you are wrong"
6. a negative; "his no was loud and clear"
7. referring to the degree to which a certain quality is present; "he was no heavier than a child" (同)no more
8. not in any degree or manner; not at all; "he is no better today"
9. quantifier; used with either mass nouns or plural count nouns for indicating a complete or almost complete lack or zero quantity of; "we have no bananas"; "no eggs left and no money to buy any"; "have you no decency?"; "did it with no help"; "Ill get you there in no time"
10. a legal document signed and sealed and delivered to effect a transfer of property and to show the legal right to possess it; "he signed the deed"; "he kept the title to his car in the glove compartment" (同)deed of conveyance, title
11. go `ding dong, like a bell (同)dong, dingdong
12. a ringing sound

PrepTutorEJDIC

1. 『新奇な』,ざん新な
2. (長編の)『小説』
3. 『最近』,近ごろ / 『新たに』,再び
4. 《文》新たに,再び
5. 《名詞の前に置いて》『一つも』(『一人も,少しも』)・・・『ない』 / 《補語につけて》『決して・・・でない』 / 《省略文で》・・・なし;・・・お断り / 《話》少ししか(あまり)・・・ない / (肯定の問いに対して)『いいえ』;(否定の問いに対して)はい,ええ / 《not, norの前に挿入して》『いや』,否 / 《形容詞の前に置その形容詞を否定して》…どころではない / 《比較級の前に置いて》ちっとも…でない,…と全く同じ / 《… or no の形で》…であってもなくても / 《驚き・困惑・不信などを表して》とんでもない / 《単数形で》『拒否』,「『いいえ』」という返事 / 《複数形で》反対[投]票
6. 『行為』,行動 / (正式の)捺印証書,権利書 / …'を'証書を作製して譲渡する
7. 〈鐘など〉‘を'ガンガン鳴らす / 〈鐘などが〉ガンガン鳴る / (鐘の)ガンガン鳴る音
8. (おもに人称代名詞・固有名詞(人名),thereの後で)had, wouldの短縮形 / (疑問文でwhere,what,whenの後で)didの短縮形;Where'd he go?=Where did he go?
9. Delaware

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/24 21:58:33」(JST)

wiki ja

[Wiki ja表示]

de novo は、ラテン語で「新たに」「再び」を意味する言葉。

• 生化学においては、数種類の異なる反応がde novo 反応またはde novo 経路と呼ばれている。例として、ヌクレオチド・コレステロール・セラミドなどがある。
• 医学においては、de novo cancer や de novo B型肝炎などと用いられる。
• 計算化学では ab initio とほぼ同義で使用される。例として、タンパク質構造予測がある。

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wiki en

[Wiki en表示]

In general usage, de novo is a Latin expression meaning "from the beginning," "afresh," "anew," "beginning again." It is used in:

Biology and chemistry

• De novo mutation, a genetic mutation that neither parent possessed nor transmitted.
• De novo transcriptome assembly, the method of creating a transcriptome without a reference genome
• De novo synthesis of complex molecules from simple molecules in biochemistry
• In bioinformatics, de novo is a form of sequencing, as in "de novo peptide sequencing."
• De novo may also be a term used to define methods for making predictions about biological features using only a computational model without extrinsic comparison to existing data. In this context, it may be sometimes interchangeable with the Latin term ab initio.

Computer science

• De novo search, signifying the start of a new (or repeated from the start) algorithm in computer science, discrete and computational geometry, and in particular, a packing problem.

Law

• Trial de novo, or a new trial in the legal system
• De novo review, an appellate standard of review for legal issues

Economics

• De novo bank, a state bank that has been in operation for five years or less
• In financial terminology, numbers reported by newly founded companies (especially the financial services industry) are qualified as de novo, to distinguish them from older companies. For example, "growth de novo" means growth of newly started companies.
• In the context of marketing and advertising, de novo means "again, but in a different way" and is linked to guerrilla and grass roots marketing campaigns.

Other uses

• Synonym of ex novo
• DeNovo Scientific Journal

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. 腎移植後の再発性TTP-HUSおよびde novo TTP-HUS recurrent and de novo ttp hus after renal transplantation
• 2. 膜性腎症と腎移植 membranous nephropathy and renal transplantation
• 3. くも膜下出血および頭蓋内動脈瘤の遅発性再発 late recurrence of subarachnoid hemorrhage and intracranial aneurysms
• 4. 膜性糸球体腎炎：移植後の再発 membranoproliferative glomerulonephritis recurrence after transplantation
• 5. 冠動脈ステント血栓症：臨床症状およびマネージメント coronary artery stent thrombosis clinical presentation and management

English Journal

• Nutritional impacts on gene expression in the surface mucosa of blue catfish (Ictalurus furcatus).

• Li C1, Beck BH2, Peatman E3.Author information 1School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL 36849, USA.2United States Department of Agriculture, Agricultural Research Service, Stuttgart National Aquaculture Research Center, Stuttgart, AR 72160, USA.3School of Fisheries, Aquaculture and Aquatic Sciences, Auburn University, Auburn, AL 36849, USA. Electronic address: peatmer@auburn.edu.AbstractShort-term feed deprivation is a common occurrence in both wild and farmed fish species, due to reproductive processes, seasonal variations in temperature, or in response to a disease outbreak. Fasting can have dramatic physiological and biological consequences for fish, including impacts on mucosal immunity which can, in turn, change host susceptibility to pathogens. Culture and selection of blue catfish (Ictalurus furcatus) has gained importance as the production of a channel catfish×blue catfish (Ictalurus punctatus×I. furcatus) hybrid has increased in the Southeast US. Following a recent examination of fasting-induced impacts on mucosal immunity in channel catfish, here we utilized Illumina-based RNA-seq expression profiling to compare changes in blue catfish gill and skin after a brief (7day) period of fasting. Transcriptome sequencing and de novo assembly of over 194million 100base-pair transcript reads was followed by differential expression analysis. Fasting altered a total of 530genes in the surface mucosa, including genes regulating the immune response, energy metabolism, mucus production, cellular cytoskeletal structure, cell proliferation, and antioxidant responses. In particular, fasting perturbed arginine synthesis and metabolism pathways in a manner likely altering macrophage activation states and immune readiness. Our findings highlight key mediators of the critical interaction between nutrition and immunity at points of pathogen adherence and entry.
• Developmental and comparative immunology.Dev Comp Immunol.2014 May;44(1):226-34. doi: 10.1016/j.dci.2013.12.014. Epub 2013 Dec 28.
• Short-term feed deprivation is a common occurrence in both wild and farmed fish species, due to reproductive processes, seasonal variations in temperature, or in response to a disease outbreak. Fasting can have dramatic physiological and biological consequences for fish, including impacts on mucosal
• PMID 24378224

• Discovery of novel insomnia leads from screening traditional Chinese medicine database.

• Chen HY1, Chang SS, Chan YC, Chen CY.Author information 1a Department of Biomedical Informatics , Asia University , Taichung , 41354 , Taiwan .AbstractInsomnia is a prominent modern disease that affects an increasing population. Undesirable side effects of commercial drugs highlight the need to develop novel insomnia drugs. Virtual screening of traditional chinese medicine Database@Taiwan (TCM Database@Taiwan) identified 2-O-Caffeoyl tartaric acid (1), 2-O-Feruloyl tartaric acid (2), and Mumefural (3) as potential agonists for both gamma-amino butyric acid (GABA) or benzodiazepine (BZ) binding sites. The TCM candidates exhibited higher affinity than GABA and Zolpidem, a phenomenon that could be attributed to higher quantity of stabilizing H-bonds. Efficacy profiles using support vector machines and pharmacophore contour also suggest drug potential of the TCM candidates. Fragments added to the de novo derivatives 3a, 3b, 3c for GABA binding site, and 1a, 2a, and 3d for BZ binding site contributed to new binding sites and structural stability, further optimizing binding to GABA or BZ binding sites. Increased opening of the ion channel by candidate ligands provide strong support for their potential biological functions. The dual binding properties of the TCM candidates present a unique opportunity to develop twin-targeting drugs with less side effects. Derivative structures can be used as starting points for developing high affinity GABAA receptor agonists with specificity towards GABA binding site and BZ binding site.
• Journal of biomolecular structure & dynamics.J Biomol Struct Dyn.2014 May;32(5):776-91. doi: 10.1080/07391102.2013.790849. Epub 2013 Jun 3.
• Insomnia is a prominent modern disease that affects an increasing population. Undesirable side effects of commercial drugs highlight the need to develop novel insomnia drugs. Virtual screening of traditional chinese medicine Database@Taiwan (TCM Database@Taiwan) identified 2-O-Caffeoyl tartaric acid
• PMID 23730798

• Genetic analysis of SS18L1 in French amyotrophic lateral sclerosis.

• Teyssou E1, Vandenberghe N2, Moigneu C1, Boillée S1, Couratier P3, Meininger V4, Pradat PF5, Salachas F4, Leguern E6, Millecamps S7.Author information 1Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, INSERM UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie (UPMC)-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France.2Hospices Civils de Lyon, Service d'ENMG, Hôpital Neurologique Pierre Wertheimer, Bron, France.3Neuroépidémiologie Tropicale, INSERM UMR1094, Université de Limoges, Limoges, France.4Département des Maladies du Système Nerveux, APHP, Centre de référence maladies rares SLA, Hôpital Pitié-Salpêtrière, Paris, France.5Département des Maladies du Système Nerveux, APHP, Centre de référence maladies rares SLA, Hôpital Pitié-Salpêtrière, Paris, France; INSERM U678, UPMC UMR-S678, Laboratoire d'Imagerie Biologique, Paris, France.6Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, INSERM UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie (UPMC)-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France; APHP, Unité Fonctionnelle de neurogénétique moléculaire et cellulaire, Département de Génétique et Cytogénétique, Hôpital Pitié-Salpêtrière, Paris, France.7Centre de Recherche de l'Institut du Cerveau et de la Moelle Epinière, INSERM UMR_S975, CNRS UMR7225, Université Pierre et Marie Curie (UPMC)-Paris 6, Hôpital Pitié-Salpêtrière, Paris, France. Electronic address: stephanie.millecamps@upmc.fr.AbstractAmyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease including about 15% of genetically determined forms. A de novo mutation in the SS18L1 (also known as CREST or KIAA0693) gene encoding the calcium-responsive transactivator and/or neuronal chromatin remodeling complex subunit has recently been identified by exome sequencing of 47 sporadic ALS trios. This Q388stop mutation deleting the last 9 amino acids was shown to impair activity-dependent dendritic outgrowth. A missense mutation (c.369T>G, p.Ileu123Met) was also found in 1 of 62 ALS families previously screened for other ALS-related genes and not carrying any mutation. To confirm the contribution of SS18L1 to ALS, we sequenced the 11 coding exons and exon-intron boundaries in 87 familial ALS (FALS). We identified 2 variants: the c.660_668del, p.Gln222_Ser224del in a patient devoid of mutation in any ALS related genes and the c.790G>A, p.Ala264Thr in a patient carrying a p.Arg96Leu variant in the OPTN gene. As these variants were not found in Single Nucleotide Polymorphism databases and were absent from 180 controls they could be new SS18L1 mutations causing ALS.
• Neurobiology of aging.Neurobiol Aging.2014 May;35(5):1213.e9-1213.e12. doi: 10.1016/j.neurobiolaging.2013.11.023. Epub 2013 Dec 3.
• Amyotrophic lateral sclerosis (ALS) is a devastating motor neuron disease including about 15% of genetically determined forms. A de novo mutation in the SS18L1 (also known as CREST or KIAA0693) gene encoding the calcium-responsive transactivator and/or neuronal chromatin remodeling complex subunit h
• PMID 24360741

Japanese Journal

• デバイス新規植込み時の合併症 (特集 ペースメーカ治療の合併症への対応)

• 今井 克彦
• 呼吸と循環 63(5), 405-412, 2015-05
• NAID 40020466067

• A case of autism spectrum disorder arising from a de novo missense mutation in POGZ

• Fukai Ryoko,Hiraki Yoko,Yofune Hiroko [他]
• Journal of human genetics 60(5), 277-279, 2015-05
• NAID 40020462593

• 第二次世界大戦期ブラジル日系移民

• 井上 早央梨
• 異文化. 論文編 (16), 17-36, 2015-04
• 本論文は、第二次世界大戦中の、ブラジル日系移民の置かれた情勢と社会的・文化的活動の考察を目的とする。1908 年にブラジル政府と日本政府の合意のもとに始まったブラジル移民は、1930 年代に絶頂期を迎えるが、その後のブラジル政府の政策と日中戦争の開始により移民数は減少する。日本が戦争において勢力を上げることでブラジル国内での反日の傾向が強まるなか、日系移民は独自のコロニアを建設し、ブラジルで生まれ …
• NAID 120005588295

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• de novoの意味 - 英和辞書 - goo辞書

de novoとは。意味や和訳。新たに，新規に(anew, afresh)；再び(again)；初めから.[ラテン語] - goo辞書は国語、英和、和英、中国語、百科事典等からまとめて探せる辞書検索サービスです。

Related Pictures

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★リンクテーブル★

リンク元	「novel」「新規」「newly」「anew」
関連記事	「DE」

「novel」

　　[★]

• 新規の、新しい

関

anew、de novo、new、newly

　 　 　 　 　

「新規」

　　[★]

英

novel、de novo、newly、de novo、anew

関

新しく、新しい

「newly」

　　[★]

• 新しく、新規に

関

anew、de novo、novel

　 　

「anew」

　　[★]

• 新規に、新しく

関

de novo、newly、novel

　

「DE」

　　[★] 線量当量 dose equivalent