出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/10/20 00:02:40」(JST)
Peptidylprolyl isomerase A (cyclophilin A) | |||||||||||||
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PDB rendering based on 1ak4. |
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Identifiers | |||||||||||||
Symbols | PPIA ; CYPA; CYPH; HEL-S-69p | ||||||||||||
External IDs | OMIM: 123840 MGI: 3648545 HomoloGene: 134504 ChEMBL: 1949 GeneCards: PPIA Gene | ||||||||||||
EC number | 5.2.1.8 | ||||||||||||
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Orthologs | |||||||||||||
Species | Human | Mouse | |||||||||||
Entrez | 5478 | 268373 | |||||||||||
Ensembl | ENSG00000196262 | ENSMUSG00000062933 | |||||||||||
UniProt | P62937 | P17742 | |||||||||||
RefSeq (mRNA) | NM_001300981 | NM_008907 | |||||||||||
RefSeq (protein) | NP_001287910 | NP_032933 | |||||||||||
Location (UCSC) | Chr 7: 44.84 – 44.86 Mb |
Chr 11: 6.42 – 6.42 Mb |
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PubMed search | [1] | [2] | |||||||||||
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Peptidylprolyl isomerase A also known as cyclophilin A or rotamase A is an enzyme that in humans is encoded by the PPIA gene.[1][2][3]
This gene encodes a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerates the folding of proteins. The encoded protein is a cyclosporin binding-protein and may play a role in cyclosporin A-mediated immunosuppression. The protein can also interact with several HIV proteins, including p55 gag, Vpr, and capsid protein, and has been shown to be necessary for the formation of infectious HIV virions. Multiple pseudogenes that map to different chromosomes have been reported.[1]
Peptidylprolyl isomerase A has been shown to interact with ITK.[4]
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リンク元 | 「CypA」「シクロフィリンA」「サイクロフィリンA」 |
関連記事 | 「A」「Ad」「cyclophilin」 |
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