cutaneous candidiasis

WordNet

1. relating to or existing on or affecting the skin; "cutaneous nerves"; "a cutaneous infection" (同)cutaneal, dermal
2. an infection caused by fungi of the genus Monilia or Candida (especially Candida albicans) (同)moniliasis, monilia disease

PrepTutorEJDIC

1. 皮膚の,皮膚を冒す

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/07/03 12:57:28」(JST)

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"Thrush (infection)" redirects here. For the hoof infection, see Thrush (horse).

Candidiasis
Classification and external resources
Oral candidiasis (thrush)
ICD-10	B37
ICD-9	112
DiseasesDB	1929
MedlinePlus	001511
eMedicine	med/264 emerg/76 ped/312 derm/67
MeSH	D002177

Candidiasis or thrush is a fungal infection (mycosis) of any of the Candida species (all yeasts), of which Candida albicans is the most common. Also commonly referred to as a yeast infection, candidiasis is also technically known as candidosis, moniliasis, and oidiomycosis.

Candidiasis encompasses infections that range from superficial, such as oral thrush and vaginitis, to systemic and potentially life-threatening diseases. Candida infections of the latter category are also referred to as candidemia and are usually confined to severely immunocompromised persons, such as cancer, transplant, and AIDS patients, as well as nontrauma emergency surgery patients.

Superficial infections of skin and mucosal membranes by Candida causing local inflammation and discomfort are common in many human populations. While clearly attributable to the presence of the opportunistic pathogens of the genus Candida, candidiasis describes a number of different disease syndromes that often differ in their causes and outcomes.

Classification

Candidiasis may be divided into the following types:

• Angular cheilitis (perlèche)
• Antibiotic candidiasis (iatrogenic candidiasis)
• Candidal intertrigo
• Candidal paronychia
• Candidal vulvovaginitis (vaginal yeast infection)
• Candidid
• Chronic mucocutaneous candidiasis
• Congenital cutaneous candidiasis
• Diaper candidiasis
• Erosio interdigitalis blastomycetica
• Oral candidiasis (thrush)
• Perianal candidiasis
• Systemic candidiasis

Signs and symptoms

Skin candidiasis

Nail candidiasis (onychomycosis)

Symptoms of candidiasis vary depending on the area affected. Most candidial infections result in minimal complications such as redness, itching and discomfort, though complications may be severe or fatal if left untreated in certain populations. In immunocompetent persons, candidiasis is usually a very localized infection of the skin or mucosal membranes, including the oral cavity (thrush), the pharynx or esophagus, the gastrointestinal tract, the urinary bladder, or the genitalia (vagina, penis).

Candidiasis is a very common cause of vaginal irritation, or vaginitis, and can also occur on the male genitals. In immunocompromised patients, Candida infections can affect the esophagus with the potential of becoming systemic, causing a much more serious condition, a fungemia called candidemia.

Thrush is commonly seen in infants. It is not considered abnormal in infants unless it lasts longer than a few weeks.

Infection of the vagina or vulva may cause severe itching, burning, soreness, irritation, and a whitish or whitish-gray cottage cheese-like discharge, often with a curd-like appearance. These symptoms are also present in the more common bacterial vaginosis. In a 2002 study published in the Journal of Obstetrics and Gynecology, only 33% of women who were self-treating for a yeast infection actually had a yeast infection, while most had either bacterial vaginosis or a mixed-type infection. Symptoms of infection of the male genitalia include red, patchy sores near the head of the penis or on the foreskin, severe itching, or a burning sensation. Candidiasis of the penis can also have a white discharge, although uncommon.^{[citation needed]}

Causes

See also: Candida albicans

Candida yeasts are commonly present in humans, and their growth is normally limited by the human immune system and by other microorganisms, such as bacteria occupying the same locations in the human body.

C. albicans was isolated from the vaginas of 19% of apparently healthy women, i.e., those who experienced few or no symptoms of infection. External use of detergents or douches or internal disturbances (hormonal or physiological) can perturb the normal vaginal flora, consisting of lactic acid bacteria, such as lactobacilli, and result in an overgrowth of Candida cells, causing symptoms of infection, such as local inflammation. Pregnancy and the use of oral contraceptives have been reported as risk factors. Diabetes mellitus and the use of antibacterial antibiotics are also linked to an increased incidence of yeast infections. Diets high in simple carbohydrates have been found to affect rates of oral candidiases, and hormone replacement therapy and infertility treatments may also be predisposing factors. Wearing wet swimwear for long periods of time is also believed to be a risk factor.

A weakened or undeveloped immune system or metabolic illnesses such as diabetes are significant predisposing factors of candidiasis. Diseases or conditions linked to candidiasis include HIV/AIDS, mononucleosis, cancer treatments, steroids, stress, and nutrient deficiency. Almost 15% of people with weakened immune systems develop a systemic illness caused by Candida species. In extreme cases, these superficial infections of the skin or mucous membranes may enter into the bloodstream and cause systemic Candida infections.

In penile candidiasis, the causes include sexual intercourse with an infected individual, low immunity, antibiotics, and diabetes. Male genital yeast infections are less common, and incidences of infection are only a fraction of those in women; however, yeast infection on the penis from direct contact via sexual intercourse with an infected partner is not uncommon.

Candida species are frequently part of the human body's normal oral and intestinal flora. Treatment with antibiotics can lead to eliminating the yeast's natural competitors for resources, and increase the severity of the condition.^{[citation needed]} Higher prevalence of colonization of C. albicans was reported in young individuals with tongue piercing, in comparison to unpierced matched individuals. In the Western Hemisphere, about 75% of females are affected at some time in their lives.

Diagnosis

Agar plate culture of C. albicans

Micrograph of esophageal candidiasis, biopsy specimen, PAS stain

Diagnosis of a yeast infection is done either via microscopic examination or culturing.

For identification by light microscopy, a scraping or swab of the affected area is placed on a microscope slide. A single drop of 10% potassium hydroxide (KOH) solution is then added to the specimen. The KOH dissolves the skin cells, but leaves the Candida cells intact, permitting visualization of pseudohyphae and budding yeast cells typical of many Candida species.

For the culturing method, a sterile swab is rubbed on the infected skin surface. The swab is then streaked on a culture medium. The culture is incubated at 37°C for several days, to allow development of yeast or bacterial colonies. The characteristics (such as morphology and colour) of the colonies may allow initial diagnosis of the organism causing disease symptoms.

Treatment

In clinical settings, candidiasis is commonly treated with antimycotics; the antifungal drugs commonly used to treat candidiasis are topical clotrimazole, topical nystatin, fluconazole, and topical ketoconazole.

For example, a one-time dose of fluconazole (150-mg tablet taken orally) has been reported as being 90% effective in treating a vaginal yeast infection. This dose is only effective for vaginal yeast infections, and other types of yeast infections may require different dosing. In severe infections, amphotericin B, caspofungin, or voriconazole may be used. Local treatment may include vaginal suppositories or medicated douches. Gentian violet can be used for thrush in breastfeeding babies, but when used in large quantities, it can cause mouth and throat ulcerations, and has been linked to mouth cancer in humans and to cancer in the digestive tract of other animals.

Chlorhexidine gluconate oral rinse is not recommended to treat candidiasis, but is effective as prophylaxis; chlorine dioxide rinse was found to have similar in vitro effectiveness against Candida.

C. albicans can develop resistance to antimycotic drugs. Recurring infections may be treatable with other antifungal drugs, but resistance to these alternative agents may also develop.

History

Descriptions of what sounds like oral thrush go back to the time of Hippocrates circa 460 - 370 BC.

The genus Candida and species C. albicans were described by botanist Christine Marie Berkhout in her doctoral thesis at the University of Utrecht in 1923. Over the years, the classification of the genera and species has evolved. Obsolete names for this genus include Mycotorula and Torulopsis. The species has also been known in the past as Monilia albicans and Oidium albicans. The current classification is nomen conservandum, which means the name is authorized for use by the International Botanical Congress (IBC).

The genus Candida includes about 150 different species; however, only a few are known to cause human infections. C. albicans is the most significant pathogenic species. Other species pathogenic in humans include C. tropicalis, C. glabrata, C. krusei, C. parapsilosis, C. dubliniensis, and C. lusitaniae.

Society and culture

Some alternative medicine proponents postulate a widespread occurrence of systemic candidiasis (or candida hypersensitivity syndrome, yeast allergy, or gastrointestinal candida overgrowth), a medically unrecognised condition. The view was most widely promoted in a book published by Dr. William Crook that hypothesized a variety of common symptoms such as fatigue, PMS, sexual dysfunction, asthma, psoriasis, digestive and urinary problems, multiple sclerosis, and muscle pain could be caused by subclinical infections of C. albicans. Crook suggested a variety of remedies to treat these symptoms, including dietary modification, prescription antifungals, and colonic irrigation. With the exception of the few dietary studies in the urinary tract infection section, conventional medicine has not used most of these alternatives, since limited scientific evidence proves either their effectiveness or subclinical systemic candidiasis is a viable diagnosis.

In 1990, alternative health vendor Nature's Way signed an FTC consent agreement not to misrepresent in advertising any self-diagnostic test concerning yeast conditions or to make any unsubstantiated representation concerning any food or supplement's ability to control yeast conditions, with a fine of $30,000 payable to the National Institutes of Health for research in genuine candidiasis.

References

External links

• Candidiasis at the Open Directory Project

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

• 1. カンジダ性間擦疹 candidal intertrigo
• 2. 慢性粘膜皮膚カンジダ症 chronic mucocutaneous candidiasis
• 3. おむつ皮膚炎 diaper dermatitis
• 4. Infectious folliculitis
• 5. 新生児におけるカンジダ感染症の臨床症状および診断 clinical manifestations and diagnosis of candida infection in neonates

English Journal

• Econazole imprinted textiles with antifungal activity.

• Hossain MA1, Lalloz A1, Benhaddou A2, Pagniez F3, Raymond M4, Le Pape P3, Simard P2, Théberge K2, Leblond J5.
• European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft für Pharmazeutische Verfahrenstechnik e.V.Eur J Pharm Biopharm.2016 Apr;101:137-44. doi: 10.1016/j.ejpb.2016.02.003. Epub 2016 Feb 13.
• In this work, we propose pharmaceutical textiles imprinted with lipid microparticles of Econazole nitrate (ECN) as a mean to improve patient compliance while maintaining drug activity. Lipid microparticles were prepared and characterized by laser diffraction (3.5±0.1μm). Using an optimized screen-
• PMID 26883854

• Chronic and Invasive Fungal Infections in a Family with CARD9 Deficiency.

• Alves de Medeiros AK1, Lodewick E2, Bogaert DJ3,4, Haerynck F3,4, Van Daele S3, Lambrecht B4,5,6, Bosma S2, Vanderdonckt L2, Lortholary O7,8, Migaud M7,9, Casanova JL7,9,10,11,12, Puel A7,9, Lanternier F7,8,9, Lambert J2, Brochez L2, Dullaers M4,5.
• Journal of clinical immunology.J Clin Immunol.2016 Apr;36(3):204-9. doi: 10.1007/s10875-016-0255-8. Epub 2016 Mar 9.
• Chronic mucocutaneous or invasive fungal infections are generally the result of primary or secondary immune dysfunction. Patients with autosomal recessive CARD9 mutations are also predisposed to recurrent mucocutaneous and invasive fungal infections with Candida spp., dermatophytes (e.g. Trichophyto
• PMID 26961233

• A case of cutaneous vegetating candidiasis in a patient with Keratitis-Ichthyosis-Deafness Syndrome.

• Reinholz M1, Hermans C1, Dietrich A1, Ruzicka T1, Braun-Falco M1.
• Journal of the European Academy of Dermatology and Venereology : JEADV.J Eur Acad Dermatol Venereol.2016 Mar;30(3):537-9. doi: 10.1111/jdv.12936. Epub 2015 Jan 20.
• PMID 25600479

Japanese Journal

• 症例報告 糖尿病でステロイドの外用を行っていた患者にみられた汎発性皮膚カンジダ症の1例

• 臨床皮膚科 = Japanese journal of clinical dermatology 70(8), 621-625, 2016-07
• NAID 40020901504

• 臨床研究・症例報告 先天性全身性カンジダ症と鑑別を要した新生児一過性多呼吸を伴った先天性皮膚カンジダ症の1例

• 小児科臨床 69(3), 455-459, 2016-03
• NAID 40020740910

• 皮膚真菌感染症 : 白癬・カンジダ症・マラセチア感染症・深在性真菌症 (特集 整形外科診療に役立つ皮膚科の知識)

• 整形・災害外科 58(12), 1593-1602, 2015-11
• NAID 40020631138

Related Links

• Candida infection of the skin: MedlinePlus Medical Encyclopedia

A candida infection of the skin can cause intense itching. Symptoms also include: Red, growing skin rash Rash on the skin folds, genitals, middle of the body, buttocks, under the breasts, and other areas of skin Infection ...

• Cutaneous Candidiasis: Background, Pathophysiology ...

Cutaneous candidiasis and other forms of candidosis are infections caused by the yeast Candida albicans or other Candida species. Yeasts are unicellular fungi that typically reproduce by budding, a process that entails ...

Related Pictures

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★リンクテーブル★

リンク元	「皮膚カンジダ症」「全身性皮膚カンジダ症」
拡張検索	「mucocutaneous candidiasis」「chronic mucocutaneous candidiasis」
関連記事	「cutaneous」「candidiasis」

「皮膚カンジダ症」

　　[★]

英

cutaneous candidiasis

ラ

candidiasis cutis

同

皮膚分芽菌症 cutaneous moniliasis, 皮膚モニリア症 cutaneous monilia

関

カンジダ症

「全身性皮膚カンジダ症」

　　[★]

関

皮膚カンジダ症 skin candidosis, cutaneous candidiasis

「mucocutaneous candidiasis」

　　[★] 皮膚粘膜カンジダ症、粘膜皮膚カンジダ症

「chronic mucocutaneous candidiasis」

　　[★] 慢性粘膜皮膚カンジダ症 CMC

「cutaneous」

　　[★]

• adj.

• 皮膚の、皮膚性の

関

cutaneously、cutis、dermal、skin

　 　

「candidiasis」

　　[★]

(pl.)candidiase

• カンジダ症