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a small tube

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小管,細管

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/26 23:06:08」(JST)

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In the kidney, the connecting tubule (CNT, or junctional tubule, or arcuate renal tubule) is a tubular segment of the renal collecting duct system that connects the distal convoluted tubule to the cortical collecting duct.

Structure

Many sources include the connecting tubule as part of the collecting duct system. However, the embryological origin is more similar to the nephron than it is to the rest of the collecting duct (which derives from the ureteric bud), and other sources therefore classify the connecting tubule with the nephron.

Some connecting tubules, usually associated with juxtamedullary nephrons, arch upwards before reaching the cortical collecting ducts. It is this "arcuate" feature which gives the tubule its alternate name.

Function

It participates in the regulation of water and electrolytes, including sodium, and chloride.

The CNT is sensitive to both isoprotenerol (more so than the cortical collecting ducts) and antidiuretic hormone (less so than the cortical collecting ducts), the latter largely determining its function in water reabsorption.

References

Eaton, Douglas C., Pooler, John P. (2004). Vander's Renal Physiology (6th ed.). Lange Medical Books/McGraw-Hill. ISBN 0-07-135728-9.
Imai M (1979). "The connecting tubule: a functional subdivision of the rabbit distal nephron segments". Kidney Int 15 (4): 346–56. doi:10.1038/ki.1979.46. PMID 513494.

External links

Physiology: 7/7ch03/7ch03p18 - Essentials of Human Physiology
Types of tubules at ndif.org
Diagram (#31) at benet.org

UpToDate Contents

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English Journal

Effect of salt intake on afferent arteriolar dilatation: Role of connecting tubule glomerular feedback (CTGF).

Wang H1, Romero CA1, Masjoan Juncos JX2, Monu SR1, Peterson EL3, Carretero OA4.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2017 Aug 23:ajprenal.00320.2017. doi: 10.1152/ajprenal.00320.2017. [Epub ahead of print]
PMID 28835421

Adaptive changes in GFR, tubular morphology, and transport in subtotal nephrectomized kidneys: modeling and analysis.

Layton AT1, Edwards A2,3, Vallon V4,5.
American journal of physiology. Renal physiology.Am J Physiol Renal Physiol.2017 Aug 1;313(2):F199-F209. doi: 10.1152/ajprenal.00018.2017. Epub 2017 Mar 22.
PMID 28331059

Renal Tubular Ubiquitin-Protein Ligase NEDD4-2 Is Required for Renal Adaptation during Long-Term Potassium Depletion.

Al-Qusairi L1,2, Basquin D1,2, Roy A3, Rajaram RD1,2, Maillard MP4, Subramanya AR5, Staub O6,2.
Journal of the American Society of Nephrology : JASN.J Am Soc Nephrol.2017 Aug;28(8):2431-2442. doi: 10.1681/ASN.2016070732. Epub 2017 Mar 13.
PMID 28289184

Japanese Journal

Nephron Distribution of Total Low Km Cyclic AMP Phosphodiesterase in Mouse, Rat and Rabbit Kidney.

Kusano Eiji,Yoshida Izumi,Takeda Shigeyuki,Homma Sumiko,Yusufi Ahad N.K.,Dousa Thomas P.,Asano Yasushi
The Tohoku Journal of Experimental Medicine 193(3), 207-220, 2001
… We assayed total low Km cAMP PDE in microdissected tubule segments, using 10−6 M (3H)-cAMP as a substrate. … Proximal convoluted tubule, proximal straight tubule, medullary thick ascending limb of Henle's loop (mTAL), and outer medullary collecting duct (OMCD) had intermediated activity. … Greater cAMP PDE activity was detected in cortical ascending limb of Henle's loop (cTAL), cortical collecting duct and in distal convoluted tubule (DCT). …
NAID 130004459103

Flow-dependent activation of maxi K^+ channels in apical membrane of rabbit connecting tubule

TANIGUCHI J
J Membr Biol 164, 35-45, 1998
NAID 30002275445

Related Pictures

★リンクテーブル★

リンク元	「結合尿細管」
関連記事	「tubule」「connectin」

「結合尿細管」

Connecting tubule
	Scheme of renal tubule and its vascular supply.
Details
Latin	tubulus renalis arcuatus
Precursor	Metanephric blastema
Identifiers
Gray's	p.1223
Dorlands; /Elsevier	t_22/12830099
	Anatomical terminology