WordNet

present at birth but not necessarily hereditary; acquired during fetal development (同)inborn, innate
relating to or involving or causing hemolysis; "hemolytic anemia" (同)haemolytic
a deficiency of red blood cells (同)anaemia
a lack of vitality (同)anaemia
genus of terrestrial or lithophytic ferns having pinnatifid fronds; chiefly of tropical America (同)genus Anemia

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/11/20 08:52:11」(JST)

Congenital hemolytic anemia (or hereditary hemolytic anemia) refers to hemolytic anemia which is primarily due to congenital disorders.^[1]

Basically classified by causative mechanism, types of congenital hemolytic anemia include:

Genetic conditions of RBC Membrane
- Hereditary spherocytosis
- Hereditary elliptocytosis
Genetic conditions of RBC metabolism (enzyme defects). This group is sometimes called congenital nonspherocytic (hemolytic) anemia, which is a term for a congenital hemolytic anemia without spherocytosis, and usually excluding hemoglobin abdormalities as well, but rather encompassing defects of glycolysis in the erythrocyte.^[2]
- Glucose-6-phosphate dehydrogenase deficiency (G6PD or favism)
- Pyruvate kinase deficiency
Hemoglobinopathies^[3]/genetic conditions of hemoglobin
- Sickle cell anemia
- Congenital dyserythropoietic anemia
- Thalassemia

^ Rahman SA, Jamal CY (June 2002). "Congenital hemolytic anemia in Bangladesh: types and clinical manifestations". Indian Pediatr 39 (6): 574–7. PMID 12084953.
^ medconditions.net > Hemolytic Congenital, Nonspherocytic Anemia Definition Retrieved April 15, 2011
^ Shah A (November 2004). "Hemoglobinopathies and other congenital hemolytic anemia". Indian J Med Sci 58 (11): 490–3. PMID 15567909.

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1. 小児における溶血性貧血の概要 overview of hemolytic anemias in children
2. ピルビン酸キナーゼ欠損症 pyruvate kinase deficiency
3. サラセミアの臨床症状および診断 clinical manifestations and diagnosis of the thalassemias
4. 脾腫を有する小児に対するアプローチ approach to the child with an enlarged spleen
5. 輸血関連の免疫性および非免疫性溶血 transfusion associated immune and non immune mediated hemolysis

Novel Gardos channel mutations linked to dehydrated hereditary stomatocytosis (Xerocytosis).

Andolfo I1,2, Russo R1,2, Manna F1,2, Shmukler BE3, Gambale A1,2, Vitiello G2,4, De Rosa G1,2, Brugnara C5, Alper SL3, Snyder LM6,7, Iolascon A1,2.
American journal of hematology.Am J Hematol.2015 Jul 15. doi: 10.1002/ajh.24117. [Epub ahead of print]
Dehydrated hereditary stomatocytosis (DHSt) is an autosomal dominant congenital hemolytic anemia with moderate splenomegaly and oftencompensated hemolysis. Affected red cells are characterized by a nonspecific cation leak of the red cell membrane, reflected in elevated sodium content, decreased pota
PMID 26178367

Grace RF1, Zanella A2, Neufeld EJ1, Morton DH3, Eber S4, Yaish H5, Glader B6.
American journal of hematology.Am J Hematol.2015 Jun 19. doi: 10.1002/ajh.24088. [Epub ahead of print]
Over the last several decades, our understanding of the genetic variation, pathophysiology, and complications of the hemolytic anemia associated with red cell pyruvate kinase deficiency has expanded. Nonetheless, there remain significant gaps in our knowledge with regard to clinical care and monitor
PMID 26087744

Aboul-Enein A1, El-Beshlawy A2, Hamdy M2, Shaheen I1, El-Saadany Z1, Samir A3, El-Samie HA1.
Gene.Gene.2015 Jun 15;564(2):206-9. doi: 10.1016/j.gene.2015.03.048. Epub 2015 Mar 25.
Iron overload is the major cause of morbidity and mortality in transfusion dependent β-thalassemia major patients. There is a sophisticated balance of body iron metabolism of storage and transport which is regulated by several factors including the peptide hepcidin. Hepcidin is the main iron regula
PMID 25816754