- 関
- CDS、coding、open reading frame、ORF
WordNet
- the approximate amount of something (usually used prepositionally as in `in the region of' (同)neighborhood
- the extended spatial location of something; "the farming regions of France"; "religions in all parts of the world"; "regions of outer space" (同)part
- a knowledge domain that you are interested in or are communicating about; "it was a limited realm of discourse"; "here we enter the region of opinion"; "the realm of the occult" (同)realm
- a large indefinite location on the surface of the Earth; "penguins inhabit the polar regions"
PrepTutorEJDIC
- (地理的な)『地域』,『地帯』;(特に広大な)地方 / 《複数形で》(宇宙などの)区分,界,属 / (身体の)部分 / (学問などの)分野,領域 / 《複数形で》(都会から離れた)地方
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2018/04/21 01:56:36」(JST)
[Wiki en表示]
The coding region of a gene, also known as the coding sequence or CDS (from coding DNA sequence), is that portion of a gene's DNA or RNA, composed of exons, that codes for protein. The region is bounded nearer the 5' end by a start codon and nearer the 3' end with a stop codon. The coding region in mRNA is bounded by the five prime untranslated region (5'-UTR) and the three prime untranslated region (3'-UTR), which are also parts of the exons.[1] The CDS is that portion of an mRNA transcript that is translated by a ribosome.
The coding region of an organism is the sum total of the organism's genome that is composed of gene coding regions.[2]
Contents
- 1 Difference with cDNA
- 2 Coding sequence annotation
- 3 See also
- 4 References
Difference with cDNA
A cDNA sequence is derived from the transcript by reverse transcription, but in this case it also contains the 5' and 3' UTRs, which are not part of the CDS (they are transcribed, but not translated). Due to this, a CDS will almost always start with an AUG codon and stop at one of the three STOP codons (UAA, UGA, UAG). These stop codons are called the stop signal.
Coding sequence annotation
While identification of open reading frames within a DNA sequence is straightforward, identifying coding sequences is not, because the cell translates only a subset of all open reading frames to proteins.[3] Currently CDS prediction uses sampling and sequencing of mRNA from cells, although there is still the problem of determining which parts of a given mRNA are actually translated to protein. CDS prediction is a subset of gene prediction, the latter also including prediction of DNA sequences that code not only for protein but also for other functional elements such as RNA genes and regulatory sequences.
See also
- Coding strand
- Noncoding DNA
References
- ^ Twyman, Richard (1 August 2003). "Gene Structure". The Wellcome Trust. Archived from the original on 28 March 2007. Retrieved 6 April 2003.
- ^ Goto, Mami; et al. (April 8, 2000). Analysis of CpG Dinucleotide Frequency in Bacterial Genomes with Respect to Genomic Regions and Codon (PDF). The Fourth Annual International Conference on Computational Molecular Biology, Tokyo, Japan. Retrieved 6 April 2009.
- ^ Furuno, Masaaki; Kasukawa, Takeya; Saito, Rintaro; Adachi, Jun; Suzuki, Harukazu; Baldarelli, Richard; Hayashizaki, Yoshihide; Okazaki, Yasushi (September 2011). "CDS Annotation in Full-Length cDNA Sequence". Genome Research. Cold Spring Harbor Laboratory Press. 21 (9): 1478–1487. doi:10.1101/gr.1060303. Retrieved 18 September 2011
UpToDate Contents
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English Journal
- Angiotensin-converting enzyme 2 is subject to post-transcriptional regulation by miR-421.
- Lambert DW, Lambert LA1, Clarke NE1, Hooper NM1, Porter KE2, Turner AJ1.
- Clinical science (London, England : 1979).Clin Sci (Lond).2014 Aug;127(4):243-9. doi: 10.1042/CS20130420.
- ACE2 (angiotensin converting enzyme 2) plays a critical role in the local tissue RAS (renin-angiotensin system) by hydrolysing the potent hypertensive and mitogenic peptide AngII (angiotensin II). Changes in the levels of ACE2 have been observed in a number of pathologies, including cardiovascular d
- PMID 24564768
- In D-loop: 40years of mitochondrial 7S DNA.
- Nicholls TJ1, Minczuk M2.
- Experimental gerontology.Exp Gerontol.2014 Aug;56:175-81. doi: 10.1016/j.exger.2014.03.027. Epub 2014 Apr 4.
- Given the tiny size of the mammalian mitochondrial genome, at only 16.5kb, it is often surprising how little we know about some of its molecular features, and the molecular mechanisms governing its maintenance. One such conundrum is the biogenesis and function of the mitochondrial displacement loop
- PMID 24709344
- Intragenic isochores (intrachores) in the platelet phosphofructokinase gene of Passeriform birds.
- Khrustalev VV1, Barkovsky EV2, Khrustaleva TA3, Lelevich SV4.
- Gene.Gene.2014 Aug 1;546(1):16-24. doi: 10.1016/j.gene.2014.05.045. Epub 2014 May 23.
- Total GC-content in the platelet phosphofructokinase gene of Zebra Finch (Taeniopygia guttata) is low (37.53±0.51%), while there are short areas (about 300 nucleotides in length) with increased GC-content overlapping its exon 4 and exon 17. GC-content in third codon positions (3GC) of those two exo
- PMID 24861647
Japanese Journal
- A novel myogenic function residing in the 5′ non-coding region of Insulin receptor substrate-1 (Irs-1) transcript
- Nagano Hikaru,Yamagishi Naoko,Tomida Chisato,Yano Chiaki,Aibara Kana,Kohno Shohei,Abe Tomoki,Ohno Ayako,Hirasaka Katsuya,Okumura Yuushi,Mills Edward M,Nikawa Takeshi,Teshima-Kondo Shigetada
- BMC Cell Biology 16(1), 8, 2015-03-11
- … Background: There is evidence that several messenger RNAs (mRNAs) are bifunctional RNAs, i.e. RNA transcript carrying both protein-coding capacity and activity as functional non-coding RNA via 5' and 3' untranslated regions (UTRs). …
- NAID 120005602600
- 一般情報源に対するSlepian-Wolf符号化問題の2次の達成可能レート領域の別表現 (ワイドバンドシステム)
- 齋藤 翔太,宮 希望,松嶋 敏泰
- 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 114(472), 159-165, 2015-03-02
- NAID 40020430896
- 一般情報源に対するSlepian-Wolf符号化問題の2次の達成可能レート領域の別表現 (情報セキュリティ)
- 齋藤 翔太,宮 希望,松嶋 敏泰
- 電子情報通信学会技術研究報告 = IEICE technical report : 信学技報 114(471), 159-165, 2015-03-02
- NAID 40020430478
Related Links
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