WordNet

being long-lasting and recurrent or characterized by long suffering; "chronic indigestion"; "a chronic shortage of funds"; "a chronic invalid"
of long duration; "chronic money problems" (同)continuing
habitual; "a chronic smoker" (同)inveterate
(medicine) the act of caring for someone (as by medication or remedial training etc.); "the quarterback is undergoing treatment for a knee injury"; "he tried every treatment the doctors suggested"; "heat therapy gave the best relief"
tending to suppress; "the government used suppressive measures to control the protest"

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1. 小児における慢性腎臓病のマネージメントの概要 overview of the management of chronic kidney disease in children
2. 成人における慢性腎臓病マネージメントの概要 overview of the management of chronic kidney disease in adults
3. 慢性骨髄性白血病の治療の概要 overview of the treatment of chronic myeloid leukemia
4. 成人における亜急性および慢性咳嗽の評価 evaluation of subacute and chronic cough in adults
5. 慢性連日性頭痛の概要 overview of chronic daily headache

Myeloid-derived suppressor cells as intruders and targets: clinical implications in cancer therapy.

Baniyash M1.
Cancer immunology, immunotherapy : CII.Cancer Immunol Immunother.2016 Jul;65(7):857-67. doi: 10.1007/s00262-016-1849-y. Epub 2016 May 25.
Chronic inflammation, typical of various diseases including cancer, is a "silent bomb within the body," leading to complications that are only evident in most cases upon their appearance, when disease is already deteriorated. Chronic inflammation is associated with accumulation of myeloid-derived su
PMID 27225641

APL1, an altered peptide ligand derived from human heat-shock protein 60, increases the frequency of Tregs and its suppressive capacity against antigen responding effector CD4 + T cells from rheumatoid arthritis patients.

Barberá A1,2, Lorenzo N1, van Kooten P3, van Roon J4, de Jager W5, Prada D6, Gómez J6, Padrón G1, van Eden W3, Broere F3, Del Carmen Domínguez M7.
Cell stress & chaperones.Cell Stress Chaperones.2016 Jul;21(4):735-44. doi: 10.1007/s12192-016-0698-0. Epub 2016 May 30.
Rheumatoid arthritis (RA) is a systemic autoimmune disease characterized by a chronic relapsing-remitting joint inflammation. Perturbations in the balance between CD4 + T cells producing IL-17 and CD4 + CD25(high)FoxP3 + Tregs correlate with irreversible bone and cartilage destruction in
PMID 27241313

Vick E1, Mahadevan D2.
Expert opinion on investigational drugs.Expert Opin Investig Drugs.2016 Jul;25(7):755-70. doi: 10.1080/13543784.2016.1175433. Epub 2016 Apr 25.
INTRODUCTION: Hematologic malignancies manipulate the immune suppressive pathways involving CTLA-4, PD-1, and others to promote immune tolerance of cancer. New monoclonal antibodies targeting immune checkpoints are showing meaningful responses in the treatment of relapsed and refractory Hodgkin lymp
PMID 27070269