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a salt or ester of acetic acid (同)ethanoate

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酢酸(さくさん)塩;アセテート(酢酸人造絹糸)

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2015/06/14 20:41:39」(JST)

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Chlormadinone acetate (INN, USAN, BAN, JAN; sold under brand names including Clordion, Gestafortin, Lormin, Non-Ovlon, Normenon, Verton, and many others), sometimes abbreviated as CMA, and also known as 17α-acetoxy-6-chloro-6-dehydroprogesterone, is a steroidal progestin with additional antiandrogen and antigonadotropic (and thus also antiestrogenic) effects.^[1]^[2]^[3]^[4] It is used clinically as a hormonal contraceptive, and in part due to its lowering of estrogen levels, but also for improved effectiveness in contraception, chlormadinone is frequently combined with ethinyl estradiol for this purpose.^[5] It is the acetate ester of chlormadinone.^[1]^[2]

References

^ ^a ^b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 419. ISBN 978-0-412-46630-4. Retrieved 29 May 2012.
^ ^a ^b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 215. ISBN 978-3-88763-075-1. Retrieved 29 May 2012.
^ Raudrant D, Rabe T (2003). "Progestogens with antiandrogenic properties". Drugs 63 (5): 463–92. doi:10.2165/00003495-200363050-00003. PMID 12600226.
^ Chassard D, Schatz B (2005). "[The antigonadrotropic activity of chlormadinone acetate in reproductive women]". Gynécologie, Obstétrique & Fertilité (in French) 33 (1-2): 29–34. doi:10.1016/j.gyobfe.2004.12.002. PMID 15752663.
^ Bouchard P (2005). "Chlormadinone acetate (CMA) in oral contraception--a new opportunity". The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception. 10 Suppl 1: 7–11. doi:10.1080/13625180500434889. PMID 16356876.

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1. 尋常性ざ瘡を有する女性のホルモン療法 hormonal therapy for women with acne vulgaris
2. 尋常性ざ瘡の治療 treatment of acne vulgaris

English Journal

[Hereditary angiœdema treatments: Recommendations from the French national center for angiœdema (Bordeaux consensus 2014)].

Bouillet L1, Lehmann A2, Gomple A3, Boccon-Gibod I4, Launay D5, Fain O6; CREAK.
Presse medicale (Paris, France : 1983).Presse Med.2015 Apr 29. pii: S0755-4982(15)00128-1. doi: 10.1016/j.lpm.2015.01.005. [Epub ahead of print]
INTRODUCTION: Treatment of hereditary angiœdema (HAE), associated or not with C1Inh deficiency, has dramatically changed these last five years. Four new therapeutic options are now available in France. The French Reference Centre for Angioedema has a consensus meeting to give recommendations about
PMID 25935791

Simultaneous determination of seven gestagens in kidney fats by Ultra Performance Convergence Chromatography tandem mass spectrometry.

Tao Y1, Paula R2, Stolker AA2, Chen D1, Yuan Z3.
Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 Apr 15;988:143-8. doi: 10.1016/j.jchromb.2015.02.034. Epub 2015 Mar 2.
An ultra-performance convergence chromatography (UPC2) system coupled tandem mass spectrometry was successfully utilised to analyse chlormadinone acetate, delmadinone acetate, fluorogestone acetate, medroxyprogesterone acetate, megestrol acetate, melengestrol acetate, chlortestasterone acetate in bo
PMID 25777477

Gynecologic follow up of 129 women on dialysis and after kidney transplantation: a retrospective cohort study.

Chakhtoura Z1, Meunier M2, Caby J2, Mercadal L3, Arzouk N4, Barrou B4, Touraine P2.
European journal of obstetrics, gynecology, and reproductive biology.Eur J Obstet Gynecol Reprod Biol.2015 Apr;187:1-5. doi: 10.1016/j.ejogrb.2015.01.004. Epub 2015 Jan 17.
OBJECTIVE: To describe the gynecologic issues and follow-up in our referral center of women on dialysis and after kidney transplantation.STUDY DESIGN: This retrospective cohort study included 129 dialysed women among whom 102 had had transplants. Data on menstrual pattern, pregnancies, contraception
PMID 25687479

Japanese Journal

酢酸クロルマジノン投与による前立腺肥大症患者の血清PSA値およびテストステロン値の変動--多施設共同前向き臨床研究

藤本清秀,平尾佳彦,大橋靖雄 [他]
泌尿器科紀要 57(4), 177-183, 2011-04
… In this prospective multicenter study, we investigated the changes in serum prostate-specific antigen (PSA) and testosterone levels after treatment with antiandrogen chlormadinone acetate (CMA) in patients with benign prostatic hyperplasia (BPH). …
NAID 120003072118

内分泌療法再燃前立腺癌に対する酢酸クロルマジノンの有用性の検討

江原英俊,加藤成一,中根慶太 [他]
泌尿器科紀要 55(4), 199-203, 2009-04
NAID 40016551889

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リンク元

「クロルマジノン」

Chlormadinone acetate
Systematic (IUPAC) name
	(8ξ,10ξ,13ξ,17α)-6-chloro-3,20-dioxopregn-4-en-17-yl acetate
Clinical data
Legal status	℞ (Prescription only);
Routes of; administration	Oral
Pharmacokinetic data
Half-life	34-38 hours
Identifiers
CAS Registry Number	302-22-7
ATC code	G03DB06
PubChem	CID: 9324
ChemSpider	8963
ChEMBL	CHEMBL110691
Chemical data
Formula	C23H29ClO4
Molecular mass	404.92696 g/mol
	SMILES CC(=O)[C@]1(CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2C=C(C4=CC(=O)CC[C@]34C)Cl)C)OC(=O)C;
	InChI InChI=1S/C23H29ClO4/c1-13(25)23(28-14(2)26)10-7-18-16-12-20(24)19-11-15(27)5-8-21(19,3)17(16)6-9-22(18,23)4/h11-12,16-18H,5-10H2,1-4H3/t16-,17+,18+,21-,22+,23+/m1/s1; Key:QMBJSIBWORFWQT-DFXBJWIESA-N ;

　　[★]

英: chlormadinone
化: クロルマジノン酢酸エステル、酢酸クロルマジノン chlormadinone acetate
商: ヴェロニカ、エフミン、クロキナン、クロキナンL、ゲシン、ゲシンL、サキオジール、ジルスタンL、プレストロン、プロスタール、プロスタールL、プロスタット、ルテジオン配合、ルトラール、レコルク、ロンステロン
関: 抗アンドロゲン薬、メストラノール

[Macdonald1997-1] F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 419. ISBN 978-0-412-46630-4. Retrieved 29 May 2012.

[Index_Nominum_2000:_International_Drug_Directory-2] Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 215. ISBN 978-3-88763-075-1. Retrieved 29 May 2012.

[pmid12600226-3] Raudrant D, Rabe T (2003). "Progestogens with antiandrogenic properties". Drugs 63 (5): 463–92. doi:10.2165/00003495-200363050-00003. PMID 12600226.

[pmid15752663-4] Chassard D, Schatz B (2005). "[The antigonadrotropic activity of chlormadinone acetate in reproductive women]". Gynécologie, Obstétrique & Fertilité (in French) 33 (1-2): 29–34. doi:10.1016/j.gyobfe.2004.12.002. PMID 15752663.

[pmid16356876-5] Bouchard P (2005). "Chlormadinone acetate (CMA) in oral contraception--a new opportunity". The European Journal of Contraception & Reproductive Health Care : the Official Journal of the European Society of Contraception. 10 Suppl 1: 7–11. doi:10.1080/13625180500434889. PMID 16356876.

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chlormadinone acetate