クロルマジノン
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/05/27 11:30:04」(JST)
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Chlormadinone
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Systematic (IUPAC) name |
6-chloro-17α-hydroxypregna-4,6-diene-3,20-dione
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Identifiers |
CASRN |
1961-77-9 |
ATC code |
G03DB06 (WHO) |
PubChem |
CID 5284533 |
ChemSpider |
4447590 |
Chemical data |
Formula |
C21H27ClO3 |
Molar mass |
362.890 g/mol |
SMILES
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O=C4\C=C3\C(\Cl)=C/[C@@H]1[C@H](CC[C@@]2([C@@](O)(C(=O)C)CC[C@@H]12)C)[C@@]3(C)CC4
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InChI
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InChI=1S/C21H27ClO3/c1-12(23)21(25)9-6-16-14-11-18(22)17-10-13(24)4-7-19(17,2)15(14)5-8-20(16,21)3/h10-11,14-16,25H,4-9H2,1-3H3/t14-,15+,16+,19-,20+,21+/m1/s1
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Key:VUHJZBBCZGVNDZ-TTYLFXKOSA-N
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Chlormadinone (INN, BAN) is a steroidal progestin which was never marketed.[1][2] An acylated derivative, chlormadinone acetate, is used clinically as a pharmaceutical drug.[1][2]
While chlormadinone is sometimes used as a synonym for chlormadinone acetate, what is almost always being referred to is actually chlormadinone acetate and not chlormadinone.
See also
- Cyproterone
- Delmadinone
- Hydromadinone
- Medroxyprogesterone
- Megestrol
References
- ^ a b F.. Macdonald (1997). Dictionary of Pharmacological Agents. CRC Press. p. 419. ISBN 978-0-412-46630-4. Retrieved 29 May 2012.
- ^ a b Index Nominum 2000: International Drug Directory. Taylor & Francis US. 2000. p. 215. ISBN 978-3-88763-075-1. Retrieved 29 May 2012.
Progestogenics
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Receptor
(ligands) |
PR
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Agonists
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Mixed (SPRMs)
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- Apigenin
- Asoprisnil
- Asoprisnil ecamate
- Kaempferol
- J1042
- LG-120,838
- Naringenin
- Syringic acid
- Telapristone
- Antagonistic: Mifepristone
- Org-31710
- Org-33628
- Ulipristal acetate
- ZK-137,316
|
|
Antagonists
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- 3α-Hydroxytibolone
- 3β-Hydroxytibolone
- Aglepristone
- Lilopristone
- Lonaprisan
- Onapristone
- Toripristone
- Valproic acid
- Vilaprisan
- ZM-150,271
- ZM-172,406
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Enzyme |
Modulators
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- See here instead (modulators of 20,22-desmolase, 17α-hydroxylase/17,20-lyase, 3β-HSD, and 21-hydroxylase).
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Others |
Precursors/prohormones
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- Cholesterol
- 22R-Hydroxycholesterol
- 20α,22R-Dihydroxycholesterol
- Pregnenolone
- Pregnenolone sulfate
- 17-Hydroxypregnenolone
|
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Indirect
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- Antigonadotropins (e.g., estrogens, progestogens, prolactin)
- GnRH agonists (e,g, GnRH, leuprorelin)
- GnRH antagonists (e.g., cetrorelix)
- Gonadotropins (e.g., FSH, hCG, LH)
- Kisspeptin
- Plasma proteins (ABP, albumin, SHBG)
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See also: Androgenics • Estrogenics • Glucocorticoids • Mineralocorticoids
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UpToDate Contents
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English Journal
- Comparison of the effects of chlormadinone acetate versus drospirenone containing oral contraceptives on metabolic and hormonal parameters in women with PCOS for a period of two-year follow-up.
- Yildizhan R1, Gokce AI, Yildizhan B, Cim N.
- Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology.Gynecol Endocrinol.2015 May;31(5):396-400. doi: 10.3109/09513590.2015.1006187. Epub 2015 Mar 4.
- OBJECTIVE: A randomized trial to compare the effects of two oral contraceptive pills containing either chlormadinone acetate or drospirenone as the progestogen, in women with PCOS for a period of two-year follow-up.METHODS: Group A received ethinyl-estradiol 0.03 mg + drospirenone 3 mg (EE�
- PMID 25739031
- [Hereditary angiœdema treatments: Recommendations from the French national center for angiœdema (Bordeaux consensus 2014)].
- Bouillet L1, Lehmann A2, Gompel A3, Boccon-Gibod I4, Launay D5, Fain O6; CREAK.
- Presse médicale (Paris, France : 1983).Presse Med.2015 May;44(5):526-32. doi: 10.1016/j.lpm.2015.01.005. Epub 2015 Apr 29.
- INTRODUCTION: Treatment of hereditary angiœdema (HAE), associated or not with C1Inh deficiency, has dramatically changed these last five years. Four new therapeutic options are now available in France. The French Reference Centre for Angioedema has a consensus meeting to give recommendations about
- PMID 25935791
- Simultaneous determination of seven gestagens in kidney fats by Ultra Performance Convergence Chromatography tandem mass spectrometry.
- Tao Y1, Paula R2, Stolker AA2, Chen D1, Yuan Z3.
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.J Chromatogr B Analyt Technol Biomed Life Sci.2015 Apr 15;988:143-8. doi: 10.1016/j.jchromb.2015.02.034. Epub 2015 Mar 2.
- An ultra-performance convergence chromatography (UPC2) system coupled tandem mass spectrometry was successfully utilised to analyse chlormadinone acetate, delmadinone acetate, fluorogestone acetate, medroxyprogesterone acetate, megestrol acetate, melengestrol acetate, chlortestasterone acetate in bo
- PMID 25777477
Japanese Journal
- Suppression of the Hypothalamic-pituitary-adrenal Axis by Maximum Androgen Blockade in a Patient with Prostate Cancer
- 酢酸クロルマジノン投与による前立腺肥大症患者の血清PSA値およびテストステロン値の変動--多施設共同前向き臨床研究
- 内分泌療法再燃前立腺癌に対する酢酸クロルマジノンの有用性の検討
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