- 細胞特異的な、細胞特異性の
WordNet
- stated explicitly or in detail; "needed a specific amount"
- a medicine that has a mitigating effect on a specific disease; "quinine is a specific for malaria"
- (sometimes followed by `to'
- being or affecting a disease produced by a particular microorganism or condition; used also of stains or dyes used in making microscope slides; "quinine is highly specific for malaria"; "a specific remedy"; "a specific stain is one having a specific affinity for particular structural elements"
- relating to or distinguishing or constituting a taxonomic species; "specific characters"
- small room in which a monk or nun lives (同)cubicle
- a device that delivers an electric current as the result of a chemical reaction (同)electric cell
- a room where a prisoner is kept (同)jail cell, prison cell
- (biology) the basic structural and functional unit of all organisms; they may exist as independent units of life (as in monads) or may form colonies or tissues as in higher plants and animals
- any small compartment; "the cells of a honeycomb"
- a small unit serving as part of or as the nucleus of a larger political movement (同)cadre
PrepTutorEJDIC
- 《名詞の前にのみ用いて》『特定の』,一定の・『明確な』,明白な・(そのものに)『特有の』,独特の《+『to』+『名』》・〈C〉(…の)特効薬《+『for』+『名』》・《複数形で》明細,細部(details)
- (刑務所の)『独房』;(修道院の)小さい独居室 / (ミツバチの)みつ房,巣穴 / 小さい部屋 / 『細胞』 / 電池 / 花粉室 / (共産党などの)細胞
UpToDate Contents
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- 1. 急性リンパ芽球性白血病における細胞遺伝学 cytogenetics in acute lymphoblastic leukemia
- 2. BおよびTリンパ球の正常な発生 normal b and t lymphocyte development
English Journal
- Three human cell types respond to multi-walled carbon nanotubes and titanium dioxide nanobelts with cell-specific transcriptomic and proteomic expression patterns.
- Tilton SC1, Karin NJ, Tolic A, Xie Y, Lai X, Hamilton RF Jr, Waters KM, Holian A, Witzmann FA, Orr G.Author information 1Environmental Molecular Sciences Laboratory, and Fundamental & Computational Sciences Directorate, Pacific Northwest National Laboratory , Richland, WA , USA.AbstractThe growing use of engineered nanoparticles (NPs) in commercial and medical applications raises the urgent need for tools that can predict NP toxicity. Global transcriptome and proteome analyses were conducted on three human cell types, exposed to two high aspect ratio NP types, to identify patterns of expression that might indicate high versus low NP toxicity. Three cell types representing the most common routes of human exposure to NPs, including macrophage-like (THP-1), small airway epithelial and intestinal (Caco-2/HT29-MTX) cells, were exposed to TiO2 nanobelts (TiO2-NB; high toxicity) and multi-walled carbon nanotubes (MWCNT; low toxicity) at low (10 µg/mL) and high (100 µg/mL) concentrations for 1 and 24 h. Unique patterns of gene and protein expressions were identified for each cell type, with no differentially expressed (p < 0.05, 1.5-fold change) genes or proteins overlapping across all three cell types. While unique to each cell type, the early response was primarily independent of NP type, showing similar expression patterns in response to both TiO2-NB and MWCNT. The early response might, therefore, indicate a general response to insult. In contrast, the 24 h response was unique to each NP type. The most significantly (p < 0.05) enriched biological processes in THP-1 cells indicated TiO2-NB regulation of pathways associated with inflammation, apoptosis, cell cycle arrest, DNA replication stress and genomic instability, while MWCNT-regulated pathways indicated increased cell proliferation, DNA repair and anti-apoptosis. These two distinct sets of biological pathways might, therefore, underlie cellular responses to high and low NP toxicity, respectively.
- Nanotoxicology.Nanotoxicology.2014 Aug;8(5):533-48. doi: 10.3109/17435390.2013.803624. Epub 2013 Jun 7.
- The growing use of engineered nanoparticles (NPs) in commercial and medical applications raises the urgent need for tools that can predict NP toxicity. Global transcriptome and proteome analyses were conducted on three human cell types, exposed to two high aspect ratio NP types, to identify patterns
- PMID 23659652
- Endocan elicits severe vascular inflammatory responses in vitro and in vivo.
- Lee W1, Ku SK, Kim SW, Bae JS.Author information 1College of Pharmacy, CMRI, Research Institute of Pharmaceutical Sciences, Kyungpook National University, Daegu, Republic of Korea; Department of Biochemistry and Cell Biology, School of Medicine, Kyungpook National University, Daegu, Republic of Korea.AbstractEndocan is a proteoglycan secreted by endothelial cells under the control of inflammatory cytokines. The aim of this study was to evaluate the effects of endocan on proinflammatory responses and on septic mice and underlying mechanisms. Human umbilical vein endothelial cells (HUVECs) or mice were exposed to lipopolysaccharide (LPS) or endocan with or without neutralizing endocan antibody. Mice were subjected to cecal ligation and puncture (CLP) surgery with or without neutralizing endocan antibody. Endocan was highly released by LPS and it enhanced proinflammatory responses. In a CLP-induced sepsis model, endocan was also highly released, but this release was prevented by administration of neutralizing endocan antibody. Circulating levels of endocan measured in patients admitted to the intensive care unit with sepsis were significantly elevated compared with control donors. Furthermore, the administration of endocan antibody reduced CLP-induced sepsis mortality. This study shows endocan can elicit severe inflammatory responses and inhibiting endocan release offers a potential strategy for treating sepsis.
- Journal of cellular physiology.J Cell Physiol.2014 May;229(5):620-30. doi: 10.1002/jcp.24485.
- Endocan is a proteoglycan secreted by endothelial cells under the control of inflammatory cytokines. The aim of this study was to evaluate the effects of endocan on proinflammatory responses and on septic mice and underlying mechanisms. Human umbilical vein endothelial cells (HUVECs) or mice were ex
- PMID 24446198
- Nonredundant function of two highly homologous octopamine receptors in food-deprivation-mediated signaling in Caenorhabditis elegans.
- Yoshida M1, Oami E, Wang M, Ishiura S, Suo S.Author information 1Department of Biological Sciences, Graduate School of Science, University of Tokyo, Tokyo, Japan.AbstractIt is common for neurotransmitters to possess multiple receptors that couple to the same intracellular signaling molecules. This study analyzes two highly homologous G-protein-coupled octopamine receptors using the model animal Caenorhabditis elegans. In C. elegans, the amine neurotransmitter octopamine induces activation of cAMP response element-binding protein (CREB) in the cholinergic SIA neurons in the absence of food through activation of the Gq-coupled octopamine receptor SER-3 in these neurons. We also analyzed another Gq-coupled octopamine receptor, SER-6, that is highly homologous to SER-3. As seen in ser-3 deletion mutants, octopamine- and food-deprivation-mediated CREB activation was decreased in ser-6 deletion mutants compared with wild-type animals, suggesting that both SER-3 and SER-6 are required for signal transduction. Cell-specific expression of SER-6 in the SIA neurons was sufficient to restore CREB activation in the ser-6 mutants, indicating that SER-6, like SER-3, functions in these neurons. Taken together, these results demonstrate that two similar G-protein-coupled receptors, SER-3 and SER-6, function in the same cells in a nonredundant manner. © 2014 Wiley Periodicals, Inc.
- Journal of neuroscience research.J Neurosci Res.2014 May;92(5):671-8. doi: 10.1002/jnr.23345. Epub 2014 Jan 21.
- It is common for neurotransmitters to possess multiple receptors that couple to the same intracellular signaling molecules. This study analyzes two highly homologous G-protein-coupled octopamine receptors using the model animal Caenorhabditis elegans. In C. elegans, the amine neurotransmitter octopa
- PMID 24446241
Japanese Journal
- 特異性を重視した新たな癌の分子イメージングと近赤外光線免疫療法 (特集 固形癌の標的イメージングと標的治療の最前線)
- 小林 久隆
- Drug delivery system : DDS : official journal of the Japan Society of Drug Delivery System 29(4), 274-284, 2014-09
- NAID 40020218470
- Ultrasound induced cancer immunotherapy.
- Unga Johan,Hashida Mitsuru
- Advanced drug delivery reviews 72, 144-153, 2014-06-15
- … Combination of bubbles with cell-targeting ligands and US provides an even more sophisticated delivery system whereby the therapy is not only site specific but also cell specific. …
- NAID 120005468357
- The Putative Promoters of Germ Cell-specific Genes and Nanog are Hypomethylated in Chicken Sperm
- KITO Gakushi,TANAKA Hiroaki,SOH Tomoki [他]
- The journal of reproduction and development 60(3), 224-229, 2014-06
- NAID 40020100731
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★リンクテーブル★
| リンク元 | 「細胞特異性」「細胞特異的」 |
| 拡張検索 | 「B-cell-specific activator protein」「B-cell-specific transcription factor」 |
| 関連記事 | 「specific」「cell」 |
「細胞特異性」
- 英
- cell-specific
- 関
- 細胞特異的
「細胞特異的」
- 英
- cell-specific
- 関
- 細胞特異性
「B-cell-specific activator protein」
B細胞特異的活性化タンパク質、B細胞特異的アクチベータータンパク質
「B-cell-specific transcription factor」
「specific」
- adj.
- (～に関して)明確な、はっきりとした(exact precise)、具体的な(in, about)
- (比較)(限定)特定の(particular)、一定の(⇔general)
- (～に)特有の、独特の(to)
- (比較)(医学)(～に)渡航のある(for)。特殊な
- (生物)(生物)種の
- 医学)特異の
- (物理)比の。物質固有の。単位質量・長さ・面積・容積で
n.