- 関
- cefuroxime、cefuroxime pivoxetil、cefuroxime sodium
WordNet
- a cephalosporin that can be given parenterally (trade name Zinacef) or orally by tablets (trade name Ceftin); indicated for infections of the lungs or throat or ears or urinary tract or meninges (同)Ceftin, Zinacef
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2015/04/09 20:12:35」(JST)
[Wiki en表示]
Cefuroxime axetil
|
Systematic (IUPAC) name |
1-Acetoxyethyl (6R,7R)-3-[(carbamoyloxy)methyl]-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino)acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate |
Clinical data |
Identifiers |
PubChem |
CID 6321416 |
ChemSpider |
4882027 |
ChEMBL |
CHEMBL1095930 |
Synonyms |
Cefuroxime 1-acetoxyethyl ester |
Chemical data |
Formula |
C20H22N4O10S |
Molecular mass
|
510.475 g/mol |
SMILES
- O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)/c3occc3)COC(=O)N)C(=O)OC(OC(=O)C)C
|
InChI
-
InChI=1S/C20H22N4O10S/c1-9(25)33-10(2)34-19(28)15-11(7-32-20(21)29)8-35-18-14(17(27)24(15)18)22-16(26)13(23-30-3)12-5-4-6-31-12/h4-6,10,14,18H,7-8H2,1-3H3,(H2,21,29)(H,22,26)/b23-13-/t10?,14-,18-/m1/s1
Key:KEJCWVGMRLCZQQ-YJBYXUATSA-N
|
Cefuroxime axetil is a second generation oral cephalosporin antibiotic. It was discovered by Glaxo now GlaxoSmithKline and introduced in 1987 as Zinnat.[1] It was approved by FDA on Dec 28, 1987.[2] It is available by GSK as Ceftin in US[3] and Ceftum in India.[4]
It is an acetoxyethyl ester prodrug of cefuroxime which is effective orally.[5] The activity depends on in vivo hydrolysis and release of cefuroxime.
References
- ^ "Our history - About GSK". GlaxoSmithKline.
- ^ http://www.drugs.com/monograph/cefuroxime-axetil.html
- ^ https://www.gsksource.com/gskprm/en/US/adirect/gskprm?cmd=ProductsByName#C
- ^ "Our products". GlaxoSmithKline.
- ^ Walter Sneader. Drug Discovery: A History. John Wiley, Chichester, UK. ISBN 0-471-89979-8.
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
English Journal
- Effervescence Assisted Fusion Technique to Enhance the Solubility of Drugs.
- Alam MA1, Al-Jenoobi FI, Al-Mohizea AM, Ali R.
- AAPS PharmSciTech.AAPS PharmSciTech.2015 Aug 12. [Epub ahead of print]
- The solubility of five poorly soluble drugs was enhanced by using an effervescence assisted solid dispersion (EASD) technique. EASDs were prepared by using modified fusion method. Drug and hydrophilic carrier were melted, and in this molten mixture, effervescence was generated by adding effervescenc
- PMID 26265190
- Uveitis attack and drug reaction due to cefuroxime axetil.
- Akman C1, Duran A, Kalafat UM, Ocak T.
- Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2015 Jul 23:1-3. [Epub ahead of print]
- Antibiotics are natural or synthetic substances that are used to control bacterial infections because antibiotics are by definition only effective against bacteria. A 30-year-old female came to our emergency clinic complaining rubor in both eyes, especially in the left eye, with swelling, rubor and
- PMID 26203731
- Removal of amoxicillin and cefuroxime axetil by advanced membranes technology, activated carbon and micelle-clay complex.
- Awwad M1, Al-Rimawi F, Dajani KJ, Khamis M, Nir S, Karaman R.
- Environmental technology.Environ Technol.2015 Jul-Aug;36(13-16):2069-78. doi: 10.1080/09593330.2015.1019935. Epub 2015 Mar 18.
- Two antibacterials, amoxicillin trihydrate and cefuroxime axetil spiked into wastewater were completely removed by sequential wastewater treatment plant's membranes, which included activated sludge, ultrafiltration (hollow fibre and spiral wound membranes with 100 and 20 kDa cut-offs), activated c
- PMID 25686519
Japanese Journal
- Preparation and Characterization of Amorphous Cefuroxime Axetil Drug Nanoparticles with Novel Technology : High-Gravity Antisolvent Precipitation
- Cefuroxime axetil 経口投与後のヒト血液および口腔組織への移行
- Investigation of chromatographic conditions for the separation of cefuroxime axetil and its geometric isomer
- Journal of chromatography. B, Analytical technologies in the biomedical and life sciences 800(1), 175-179, 2004-02-05
- NAID 10016547461
Related Links
- Cefuroxime Axetil [CXM-AX] セフロキシム・アキセチル, セフェム系 1. 商品名 先発品 オラセフ錠250mg 【グラクソ・スミスクライン, 第一三共】 2. 日本における発売年 1998(平成10)年 3. 特長 セフロキシムのプロドラッグであり、エステル ...
- Learn about the prescription medication Ceftin (Cefuroxime Axetil), drug uses, dosage, side effects, drug interactions, warnings, reviews and patient labeling. ... CEFTIN (cefuroxime axetil) Tablets are film-coated and contain the ...
★リンクテーブル★
[★]
- 英
- cefuroxime CXM
- ラ
- cefuroximum
- 化
- セフロキシムアキセチル cefuroxime axetil、セフロキシムピボキセチル cefuroxime pivoxetil、セフロキシムナトリウム cefuroxime sodium
- 商
- オラセフ、Ceftin, Kefurox, Zinacef
[★]
- 関
- cefuroxime、cefuroxime axetil、cefuroxime sodium
[★]
- 関
- cefuroxime、cefuroxime axetil、cefuroxime pivoxetil
[★]
- 英
- cefuroxime axetil
- 関
- セフロキシム