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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/01/10 14:58:58」(JST)

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Cefuroxime is an enteral second-generation cephalosporin antibiotic. It was discovered by the Glaxo, now GlaxoSmithKline and first marketed in 1978 as Zinacef. It received approval from the U.S. Food and Drug Administration in October of 1983.^[1]

Cefuroxime axetil is an acetoxyetyl-ester-prodrug of cefuroxime which is effective orally.^[2]

Medical uses

As with the other cephalosporins, although as a second-generation variety, it is less susceptible to beta-lactamase. Hence, it may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae, and Lyme disease. Unlike most other second-generation cephalosporins, cefuroxime can cross the blood-brain barrier.

Side effects

Cefuroxime is generally well-tolerated and its side effects are usually transient. If ingested after food, this antibiotic is both better absorbed and less likely to cause its most common side effects of diarrhea, nausea, vomiting, headaches/migraines, dizziness, and abdominal pain compared to most antibiotics in its class.^{[citation needed]}

Although a widely stated cross-allergic risk of about 10% exists between cephalosporins and penicillin, recent assessments have shown no increased risk for a cross-allergic reaction for cefuroxime and several other second-generation or later cephalosporins.^[3]

Trade names

In US it is available as Zinacef by Covis Pharmaceuticals as the company acquired the US rights of the product from GSK.^[4] In Bangladesh it is available as Xorimax by Sandoz. In India it is available as Supacef by GSK.^[5] In Poland it is available as Zamur by Mepha, subsidiary of Teva Pharmaceutical Industries.^[6]

References

^ "Cefuroxime medical facts from". Drugs.com.
^ Walter Sneader. "Drug Discovery: History".
^ Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of family practice 55 (2): 106–12. PMID 16451776.
^ http://www.covispharma.ch/assets/pdf/covis-pharma-acquires-portfolio-of-drugs-from-glaxosmithkline.pdf
^ "GlaxoSmithKline Pharmaceuticals Limited – Prescription Medicines – Anti-Infective". Gsk-india.com. 26 March 2013.
^ "Charakterystyka produktu lecznicznego" (PDF). Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych. 12 November 2015.

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5. セフェム系 cephalosporins

English Journal

In vitro susceptibility of European human Borrelia burgdorferi sensu stricto strains to antimicrobial agents.

Veinović G, Cerar T, Strle F, Lotrič-Furlan S, Maraspin V, Cimperman J, Ružić-Sabljić E.SourceDepartment of Microbiology and Immunology, Faculty of Pharmacy, University of Belgrade, Vojvode Stepe 450, 11221 Belgrade, Serbia.
International journal of antimicrobial agents.Int J Antimicrob Agents.2013 Mar;41(3):288-91. doi: 10.1016/j.ijantimicag.2012.11.016. Epub 2013 Jan 9.
Broth microdilution and macrodilution assays were used to determine minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) of six antimicrobial agents (ceftriaxone, cefuroxime sodium, azithromycin, amoxicillin, doxycycline and amikacin) for nine European human isolat
PMID 23312603

An 11-year analysis of the prevalent uropathogens and the changing pattern of Escherichia coli antibiotic resistance in 38,530 community urinary tract infections, Dublin 1999-2009.

Cullen IM, Manecksha RP, McCullagh E, Ahmad S, O'Kelly F, Flynn R, McDermott TE, Murphy P, Grainger R, Fennell JP, Thornhill JA.SourceDepartment of Urology, AMNCH, Tallaght, Dublin 24, Ireland. imcullen@gmail.com
Irish journal of medical science.Ir J Med Sci.2013 Mar;182(1):81-9. doi: 10.1007/s11845-012-0834-5. Epub 2012 Jun 6.
BACKGROUND: Knowledge of local antimicrobial resistance patterns is essential for evidence-based empirical antibiotic prescribing, and a cutoff point of 20% has been suggested as the level of resistance at which an agent should no longer be used empirically. We sought to identify the changing incide
PMID 22669684

Analysis of the effect of integrons on drug-resistant Staphylococcus aureus by multiplex PCR detection.

Ren C, Zhao Y, Shen Y.SourceDepartment of Clinical Laboratory, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan 450052, P.R. China.
Molecular medicine reports.Mol Med Rep.2013 Mar;7(3):719-24. doi: 10.3892/mmr.2013.1284. Epub 2013 Jan 21.
The aim of this study was to detect class Ⅰ, II and III integrons using multiplex PCR, and to analyze the role that these integrons play in mediating multidrug-resistant Staphylococcus aureus (SA). The sensitivity of SA to 20 types of antibiotics was examined
PMID 23337960

Japanese Journal

ドプラム注射薬の配合変化試験に関する研究

村瀬勢津子,落合かおり,青木路恵,朝長文弥
病院薬学 13(4), 244-260, 1987-08-20
… Mixing with following injections should be avoided: Neophylin, Soldactone, Lasix, Horizone, Solu-cortef, Hydrocortone, Decadron, Predonine, Solu-medorol, Ravonal, Nutrase, Foliamin, Viscorin, Aspara-K, Futraful, Pentcillin, Pansporin, Bestcall, Cefortax, Cefoperazin, Yamatetan, Cefametazone, Shiomarin, Suncefal, Viccilin-S and Zinacef. …
NAID 110001798481

Related Pictures

Zinacef - patient information, description, dosage and directions. Image of Zinacef powd for inj 750 mg 750 mg Vial | MIMS.com Malaysia Zinacef injectable powd 750 mg, 750 mg, Vial, MIMS.com Zinacef Dosage Reviews: The Broad Spectrum Antibiotic for Acute Bacterial Infections Image of zinacef inj 750 mg 750 mg Vial | MIMS.com Philippines SafeFetus Drug Search Index of /Images/static_web_tinyimagesdataset/z/zinacef

★リンクテーブル★

リンク元	「セフロキシム」
関連記事	「zinacef」

「セフロキシム」

Cefuroxime
Systematic (IUPAC) name
	(6R,7R)-3-{[(aminocarbonyl)oxy]methyl}-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino) acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names	Zinacef, Ceftin
MedlinePlus	a601206
Pregnancy; category	B;
Legal status	℞ (Prescription only);
Routes of; administration	intramuscular, intravenous
Pharmacokinetic data
Bioavailability	37% on an empty stomach, up to 52% if taken after food
Biological half-life	80 minutes
Excretion	Urine 66–100% unchanged
Identifiers
CAS Number	55268-75-2
ATC code	J01DC02 S01AA27 QJ51DC02
PubChem	CID: 5361202
DrugBank	DB01112
ChemSpider	4514699
UNII	O1R9FJ93ED
KEGG	D00262
ChEMBL	CHEMBL466
Chemical data
Formula	C16H16N4O8S
Molecular mass	424.386 g/mol
	SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)\c3occc3)COC(=O)N)C(=O)O ;
	InChI InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9+/t10-,14-/m1/s1 ; Key:JFPVXVDWJQMJEE-SWWZKJRFSA-N ;
(verify)

　　[★]

英: cefuroxime CXM
ラ: cefuroximum
化: セフロキシムアキセチル cefuroxime axetil、セフロキシムピボキセチル cefuroxime pivoxetil、セフロキシムナトリウム cefuroxime sodium
商: オラセフ、Ceftin, Kefurox, Zinacef

「zinacef」

　　[★]

同: Ceftin, Kefurox, Zinacef
関: Cefuroxime

[1] "Cefuroxime medical facts from". Drugs.com.

[2] Walter Sneader. "Drug Discovery: History".

[pmid16451776-3] Pichichero ME (2006). "Cephalosporins can be prescribed safely for penicillin-allergic patients" (PDF). The Journal of family practice 55 (2): 106–12. PMID 16451776.

[4] ttp://www.covispharma.ch/assets/pdf/covis-pharma-acquires-portfolio-of-drugs-from-glaxosmithkline.pdf

[5] "GlaxoSmithKline Pharmaceuticals Limited – Prescription Medicines – Anti-Infective". Gsk-india.com. 26 March 2013.

[6] "Charakterystyka produktu lecznicznego" (PDF). Urząd Rejestracji Produktów Leczniczych, Wyrobów Medycznych i Produktów Biobójczych. 12 November 2015.

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Zinacef