Ceftin

セフロキシム

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出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2013/04/12 15:17:59」(JST)

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Cefuroxime

Systematic (IUPAC) name
(6R,7R)-3-{[(aminocarbonyl)oxy]methyl}-7-{[(2Z)-2-(2-furyl)-2-(methoxyimino) acetyl]amino}-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid
Clinical data
Trade names	Ceftin, Zinacef
MedlinePlus	a601206
Pregnancy cat.	Not known to be harmful (BNF)
Legal status	Prescription Only Medicine
Routes	intramuscular, intravenous
Pharmacokinetic data
Bioavailability	37% on empty stomach, up to 52% if taken after food
Half-life	80 minutes
Excretion	Urine 66-100% Unchanged
Identifiers
CAS number	55268-75-2 Y
ATC code	J01DC02 S01AA27 QJ51DC02
PubChem	CID 5361202
DrugBank	DB01112
ChemSpider	4514699 Y
UNII	O1R9FJ93ED Y
KEGG	D00262 Y
ChEMBL	CHEMBL466 Y
Chemical data
Formula	C16H16N4O8S
Mol. mass	424.386 g/mol
SMILES O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=N\OC)\c3occc3)COC(=O)N)C(=O)O
InChI InChI=1S/C16H16N4O8S/c1-26-19-9(8-3-2-4-27-8)12(21)18-10-13(22)20-11(15(23)24)7(5-28-16(17)25)6-29-14(10)20/h2-4,10,14H,5-6H2,1H3,(H2,17,25)(H,18,21)(H,23,24)/b19-9+/t10-,14-/m1/s1 Y Key:JFPVXVDWJQMJEE-SWWZKJRFSA-N Y
Y (what is this?)  (verify)

Cefuroxime is an oral and parenteral second generation cephalosporin antibiotic. It was discovered by Glaxo now GlaxoSmithKline and introduced in 1978 as Zinacef. It was approved by FDA on Oct 19, 1983. In US it is available as Zinacef by Covis Pharmaceuticals as the company acquired the US rights of the product from GSK. In India it is available as Supacef by GSK. Cefuroxime axetil is an acetoxyetyl ester prodrug of cefuroxime which is effective orally.

Indications

As for the other cephalosporins, although as a second-generation it is less susceptible to beta-lactamase and so may have greater activity against Haemophilus influenzae, Neisseria gonorrhoeae and Lyme disease. Unlike other second generation cephalosporins, cefuroxime can cross the blood-brain-barrier.

Side effects

Cefuroxime is generally well tolerated and side effects are usually transient. Cefuroxime, if ingested after food, is both better absorbed and less likely to cause its most common side effects of diarrhea, nausea, vomiting, headaches/migraines, dizziness and abdominal pain compared to most antibiotics in its class.^{[citation needed]}

Although there is a widely quoted cross-allergy risk of 10% between cephalosporins and penicillin, recent assessments have shown no increased risk for cross-allergy for cefuroxime and several other 2nd generation or later cephalosporins.

References

UpToDate Contents

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• 1. セフェム系 cephalosporins
• 2. ライム病の治療 treatment of lyme disease
• 3. Borrelia miyamotoi感染症 borrelia miyamotoi infection
• 4. 小児における急性中耳炎：治療 acute otitis media in children treatment
• 5. 無脾症患者における敗血症の予防 prevention of sepsis in the asplenic patient

English Journal

• Uveitis attack and drug reaction due to cefuroxime axetil.

• Akman C1, Duran A2, Kalafat UM1, Ocak T2.
• Cutaneous and ocular toxicology.Cutan Ocul Toxicol.2016 Sep;35(3):254-6. doi: 10.3109/15569527.2015.1067817. Epub 2015 Jul 23.
• Antibiotics are natural or synthetic substances that are used to control bacterial infections because antibiotics are by definition only effective against bacteria. A 30-year-old female came to our emergency clinic complaining rubor in both eyes, especially in the left eye, with swelling, rubor and
• PMID 26203731

• [Lyme disease--clinical manifestations and treatment].

• Stock I.
• Medizinische Monatsschrift für Pharmazeuten.Med Monatsschr Pharm.2016 May;39(5):197-204; quiz 205-6.
• Lyme disease (Lyme borreliosis) is a systemic infectious disease that can present in a variety of clinical manifestations. The disease is caused by a group of spirochaetes--Borrelia burgdorferi sensu lato or Lyme borrelia--that are transmitted to humans by the bite of Ixodes ticks. Lyme disease is t
• PMID 27348896

• Diagnosis, Treatment, and Prevention of Lyme Disease, Human Granulocytic Anaplasmosis, and Babesiosis: A Review.

• Sanchez E1, Vannier E1, Wormser GP2, Hu LT3.
• JAMA.JAMA.2016 Apr 26;315(16):1767-77. doi: 10.1001/jama.2016.2884.
• IMPORTANCE: Lyme disease, human granulocytic anaplasmosis (HGA), and babesiosis are emerging tick-borne infections.OBJECTIVE: To provide an update on diagnosis, treatment, and prevention of tick-borne infections.EVIDENCE REVIEW: Search of PubMed and Scopus for articles on diagnosis, treatment, and p
• PMID 27115378

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★リンクテーブル★

リンク元	「セフロキシム」
関連記事	「ceftin」

「セフロキシム」

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英

cefuroxime CXM

ラ

cefuroximum

化

セフロキシムアキセチル cefuroxime axetil、セフロキシムピボキセチル cefuroxime pivoxetil、セフロキシムナトリウム cefuroxime sodium

商

オラセフ、Ceftin, Kefurox, Zinacef

「ceftin」

　　[★]

同

Ceftin, Kefurox, Zinacef

関

Cefuroxime