セフカペンピボキシル
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出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2016/04/30 00:34:20」(JST)
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Cefcapene
|
Systematic (IUPAC) name |
(6R,7R)-3-{[(Aminocarbonyl)oxy]methyl}-7-{(Z)-[2-(2-amino-4-thiazolyl)-1-oxo-2-pentenyl]amino}-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-ene-2-carboxylic acid
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Clinical data |
AHFS/Drugs.com |
International Drug Names |
Routes of
administration |
Oral |
Legal status |
Legal status |
|
Identifiers |
CAS Number |
135889-00-8 Y |
ATC code |
J01DD17 (WHO) |
PubChem |
CID 6436055 |
ChemSpider |
4940731 N |
UNII |
4D5D3422MW Y |
KEGG |
D07638 Y |
ChEBI |
CHEBI:131729 |
ChEMBL |
CHEMBL582912 N |
Chemical data |
Formula |
C17H19N5O6S2 |
Molar mass |
453.49 g/mol |
SMILES
-
O=C2N1/C(=C(\CS[C@@H]1[C@@H]2NC(=O)C(=C/CC)\c3nc(sc3)N)COC(=O)N)C(=O)O
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InChI
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InChI=1S/C17H19N5O6S2/c1-2-3-8(9-6-30-16(18)20-9)12(23)21-10-13(24)22-11(15(25)26)7(4-28-17(19)27)5-29-14(10)22/h3,6,10,14H,2,4-5H2,1H3,(H2,18,20)(H2,19,27)(H,21,23)(H,25,26)/b8-3-/t10-,14-/m1/s1 N
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Key:HJJRIJDTIPFROI-NVKITGPLSA-N N
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NY (what is this?) (verify) |
Cefcapene (INN) is a third-generation cephalosporin antibiotic.
Antibacterials: cell envelope antibiotics (J01C-J01D)
|
|
Intracellular |
- Inhibit peptidoglycan subunit synthesis and transport: NAM synthesis inhibition (Fosfomycin)
- DADAL/AR inhibitors (Cycloserine)
- bactoprenol inhibitors (Bacitracin)
|
|
Glycopeptide |
- Inhibit PG chain elongation: Vancomycin# (Oritavancin
- Telavancin)
- Teicoplanin (Dalbavancin)
- Ramoplanin
|
|
β-lactams/
(Inhibit PBP
cross-links) |
|
|
Other |
- polymyxins/detergent
- depolarizing
- Hydrolyze NAM-NAG
- Gramicidin
- Isoniazid
- Teixobactin
|
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
|
English Journal
- Three cases of perioral dermatitis related to fusobacteria treated with β-lactam antibiotics.
- Ishiguro N1, Maeda A, Suzuki K, Yamana Y, Fukuya Y, Kawashima M.
- The Journal of dermatological treatment.J Dermatolog Treat.2014 Dec;25(6):507-9. doi: 10.3109/09546634.2012.757284. Epub 2013 Feb 24.
- BACKGROUND: The oral tetracyclines, especially minocycline hydrochloride, are often used as an effective treatment for perioral dermatitis; however, they are sometimes difficult to use, especially in children, because of the side effects.OBJECTIVE: The effectiveness of β-lactam antibiotics was eval
- PMID 23240905
- Positive skin prick test to cefcapene pivoxil hydrochloride hydrate: a case report.
- Yamazato S, Nakai N, Katoh N.
- Allergology international : official journal of the Japanese Society of Allergology.Allergol Int.2013 Jun;62(2):263-4. doi: 10.2332/allergolint.12-LE-0524. Epub 2013 Apr 25.
- PMID 23612491
- Stability-Indicating HPLC Method for the Determination of Cefcapene Pivoxil.
- Zalewski P1, Cielecka-Piontek J, Garbacki P, Jelińska A, Karaźniewicz-Łada M.
- Chromatographia.Chromatographia.2013 Apr;76(7-8):387-391. Epub 2012 Sep 18.
- The stability-indicating LC assay method was developed and validated for quantitative determination of cefcapene pivoxil in the presence of degradation products formed during forced degradation studies. An isocratic RP-HPLC method was developed with a Lichrospher RP-18 (250 mm × 4.6 mm, 5 μm)
- PMID 23555152
Japanese Journal
- 伊藤 香世子,日野 頼真,千葉 由幸,相原 道子,池澤 善郎,堀内 義仁
- Journal of environmental dermatology and cutaneous allergology = / the Japanese Society for Dermatoallergology and Contact Dermatitis 5(1), 36-38, 2011-01-31
- NAID 10027902336
- 小児の細菌性呼吸器感染症に対する amoxicillin, cefcapene-pivoxil および faropenem の多施設共同無作為比較試験
- 坂田 宏
- 日本化学療法学会雜誌 = Japanese journal of chemotherapy 58(3), 239-247, 2010-05-10
- NAID 10026252801
Related Links
- Cefcapene Pivoxil [CFPN-PI] セフカペン ピボキシル, セフェム系(セファロスポリン系) 1. 商品名 先発品 フロモックス小児用細粒100mg 【塩野義製薬】 フロモックス錠75mg/フロモックス錠100mg 【塩野義製薬】 後発品 後発品15件 ...
- Buy Cefcapene Pivoxil Hydrochloride (CAS 147816-23-7), antibacterial agent with Gram-(+)/(-) activity, from Santa Cruz. MF: C23H30ClN5O8S2, MW: 604.10 ... Cefcapene Pivoxil Hydrochloride is an antibacterial agent that has ...
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