- 関
- CD-MPR
WordNet
- relying on or requiring a person or thing for support, supply, or what is needed; "dependent children"; "dependent on moisture"
- addicted to a drug (同)dependant, drug-addicted, hooked, strung-out
- contingent on something else (同)dependant, qualified
- (of a clause) unable to stand alone syntactically as a complete sentence; "a subordinate (or dependent) clause functions as a noun or adjective or adverb within a sentence" (同)subordinate
- a salt of phosphoric acid (同)orthophosphate, inorganic_phosphate
- carbonated drink with fruit syrup and a little phosphoric acid
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
- a positively charged ion
PrepTutorEJDIC
- 『頼っている』,依存している,従属している / 扶養される人(家族)
- 〈U〉リン酸塩 / 《複数形で》リン酸肥料
- =sense organ / 受信装置
- 陽イオン,正イオン
UpToDate Contents
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- 1. カルシウムおよびリン酸バランスの調節 regulation of calcium and phosphate balance
- 2. 副甲状腺ホルモンの分泌および作用 parathyroid hormone secretion and action
- 3. カルシウム感知性受容体障害：家族性低カルシウム尿性高カルシウム血症および常染色体優性低カルシウム血症 disorders of the calcium sensing receptor familial hypocalciuric hypercalcemia and autosomal dominant hypocalcemia
- 4. 幼児および小児における低カルシウム血症の病因 etiology of hypocalcemia in infants and children
- 5. 鎌状細胞貧血における臨床的ばらつき clinical variability in sickle cell anemia
English Journal
- Testosterone influences the expression and distribution of the cation-dependent mannose-6-phosphate receptor in rat epididymis. Implications in the distribution of enzymes.
- Carvelli L1, Bannoud N, Aguilera AC, Sartor T, Malossi E, Sosa MA.Author information 1Laboratorio de Biología y Fisiología Celular 'Dr. Francisco Bertini', Instituto de Histología y Embriología, CONICET - Facultad de Ciencias Médicas, Universidad Nacional de Cuyo, Mendoza, Argentina; Instituto de Ciencias Básicas (ICB), Universidad Nacional de Cuyo, Mendoza, Argentina.AbstractThe mammalian epididymis plays a role in sperm maturation through its secretory activity. Among the proteins secreted by the epithelium, there are significant amounts of acid hydrolases. In most cell types, the normal distribution of lysosomal enzymes is mediated by mannose-6-phosphate receptors (MPRs). In this study, we analysed the expression and distribution of the cation-dependent MPR (CD-MPR) in epididymis from control, castrated or castrated rats with testosterone replacement. It was observed that expression of CD-MPR increased due to castration in all regions of the epididymis, which was reversed by injection of testosterone. We also measured the activity of α-mannosidase and observed that the castration tends to increase the retention of this enzyme in the tissue, which is reversed by the hormone replacement. In corpus, this resulted in a reduced secretion of the enzyme. Immunohistochemistry showed that CD-MPR has a supranuclear location (different from the cation-independent MPR), most likely in principal cells, and low reactivity in other cell types. The signal in castrated animals was more intense and tended to redistribute towards the apical cytoplasm. Thus, we concluded that expression and distribution of CD-MPR is affected by decrease of testosterone in rat epididymis, and this could change the distribution of lysosomal enzymes.
- Andrologia.Andrologia.2014 Apr;46(3):224-30. doi: 10.1111/and.12065. Epub 2013 Jan 7.
- The mammalian epididymis plays a role in sperm maturation through its secretory activity. Among the proteins secreted by the epithelium, there are significant amounts of acid hydrolases. In most cell types, the normal distribution of lysosomal enzymes is mediated by mannose-6-phosphate receptors (MP
- PMID 23290006
- Rotaviruses reach late endosomes and require the cation-dependent mannose-6-phosphate receptor and the activity of cathepsin proteases to enter the cell.
- Díaz-Salinas MA1, Silva-Ayala D, López S, Arias CF.Author information 1Instituto de Biotecnología, Universidad Nacional Autónoma de México, Cuernavaca, Morelos, Mexico.AbstractRotaviruses (RVs) enter cells through different endocytic pathways. Bovine rotavirus (BRV) UK uses clathrin-mediated endocytosis, while rhesus rotavirus (RRV) employs an endocytic process independent of clathrin and caveolin. Given the differences in the cell internalization pathway used by these viruses, we tested if the intracellular trafficking of BRV UK was the same as that of RRV, which is known to reach maturing endosomes (MEs) to infect the cell. We found that BRV UK also reaches MEs, since its infectivity depends on the function of Rab5, the endosomal sorting complex required for transport (ESCRT), and the formation of endosomal intraluminal vesicles (ILVs). However, unlike RRV, the infectivity of BRV UK was inhibited by knocking down the expression of Rab7, indicating that it has to traffic to late endosomes (LEs) to infect the cell. The requirement for Rab7 was also shared by other RV strains of human and porcine origin. Of interest, most RV strains that reach LEs were also found to depend on the activities of Rab9, the cation-dependent mannose-6-phosphate receptor (CD-M6PR), and cathepsins B, L, and S, suggesting that cellular factors from the trans-Golgi network (TGN) need to be transported by the CD-M6PR to LEs to facilitate RV cell infection. Furthermore, using a collection of UK × RRV reassortant viruses, we found that the dependence of BRV UK on Rab7, Rab9, and CD-M6PR is associated with the spike protein VP4. These findings illustrate the elaborate pathway of RV entry and reveal a new process (Rab9/CD-M6PR/cathepsins) that could be targeted for drug intervention.
- Journal of virology.J Virol.2014 Apr;88(8):4389-402. doi: 10.1128/JVI.03457-13. Epub 2014 Feb 5.
- Rotaviruses (RVs) enter cells through different endocytic pathways. Bovine rotavirus (BRV) UK uses clathrin-mediated endocytosis, while rhesus rotavirus (RRV) employs an endocytic process independent of clathrin and caveolin. Given the differences in the cell internalization pathway used by these vi
- PMID 24501398
- Quantitative proteomics of extracellular vesicles released from human monocyte-derived macrophages upon β-glucan stimulation.
- Cypryk W, Ohman T, Eskelinen EL, Matikainen S, Nyman TA.AbstractFungal infections (mycoses) are common diseases of varying severity that cause problems especially to immunologically compromised people. Fungi express a variety of pathogen-associated molecular patterns on their surface including β-glucans, which are important immunostimulatory components of fungal cell walls. During stimulatory conditions of infection and colonization, besides intensive intracellular response, human cells actively communicate on the intercellular level by secreting proteins and other biomolecules with several mechanisms. Vesicular secretion remains one of the most important paths for the proteins to exit the cell. Here, we have used high-throughput quantitative proteomics combined with bioinformatics to characterize and quantify vesicle-mediated protein release from β-glucan-stimulated human macrophages differentiated in vitro from primary blood monocytes. We show that β-glucan stimulation induces vesicle-mediated protein secretion. Proteomic study identified 540 distinct proteins from the vesicles, and the identified proteins show a proteomic signature characteristic for their cellular origin. Importantly, we identified several receptors, including cation-dependent mannose-6-phosphate receptor, macrophage scavenger receptor, and P2X7 receptor which have not been identified from vesicles before. Proteomic data together with detailed pathway and network analysis showed that integrins and their cytoplasmic cargo proteins are highly abundant in extracellular vesicles released upon β-glucan stimulation. In conclusion, the present data provides a solid basis for further studies on the functional role of vesicular protein secretion upon fungal infection.
- Journal of proteome research.J Proteome Res.2014 Mar 26. [Epub ahead of print]
- Fungal infections (mycoses) are common diseases of varying severity that cause problems especially to immunologically compromised people. Fungi express a variety of pathogen-associated molecular patterns on their surface including β-glucans, which are important immunostimulatory components of funga
- PMID 24670152
Japanese Journal
- Specific depletion of GGA2 causes cathepsin D missorting in HeLa cells
- Archives of histology and cytology 70(5), 303-312, 2007-12-01
- NAID 10021186983
- Overexpression of cation-dependent mannose 6-phosphate receptor prevents cell death induced by serum deprivation in PC12 cells
- Biochem. Biophys. Res. Commun. 251, 204-208, 1998
- NAID 80010575633
- Molecular basis of lysosomal enzyme recognition : three-dimensional structure of the cation-dependent mannose 6-phosphate receptor
- Cell 93, 639-648, 1998
- NAID 80010298134
Related Links
- CFG Participating Investigators contributing to the understanding of this paradigm CFG Participating Investigators (PIs) with interest in mannose 6-phosphate receptors include: Ajit Varki Non-PIs using CFG resources to study ...
- Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi ...
Related Pictures
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★リンクテーブル★
| リンク元 | 「CD-MPR」「カチオン依存性マンノース6リン酸受容体」 |
| 関連記事 | 「phosphate」「dependent」「cation」「mannose」 |
「CD-MPR」
「カチオン依存性マンノース6リン酸受容体」
「phosphate」
- n.
- 関
- inorganic phosphate、orthophosphate、orthophosphoric acid、phospho、phosphoester、phosphoric、phosphoric acid、phosphoric acid ester、phosphorus
「dependent」
- adj.
- 依存性の、依存的な、依存型の、依存の
「cation」
- 関
- cationic
- 関
- See also specific cations