WordNet

remove the core or center from; "core an apple"
(computer science) a tiny ferrite toroid formerly used in a random access memory to store one bit of data; now superseded by semiconductor memories; "each core has three wires passing through it, providing the means to select and detect the contents of each bit" (同)magnetic core
a bar of magnetic material (as soft iron) that passes through a coil and serves to increase the inductance of the coil
the chamber of a nuclear reactor containing the fissile material where the reaction takes place
a small group of indispensable persons or things; "five periodicals make up the core of their publishing program" (同)nucleus, core group
a cylindrical sample of soil or rock obtained with a hollow drill
the center of an object; "the ball has a titanium core"
the central part of the Earth
relating to or causing or involving catalysis; "catalytic reactions"

PrepTutorEJDIC

〈C〉(果物の)『しん』 / 〈U〉(物事の)核心 / 〈C〉(電気の)磁心,磁極鉄心 / …‘の'しんを抜く
触媒[作用]の
(驚いて)わあっ,えっ
Congress of Racial Equality(米国)人種平等会議

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1. 皮膚剥脱症候群peeling skin syndrome [show details]
…conserved, functionally important domain called the central catalytic core . Most mutations affect amino acids located in the catalytic core and the beta sandwich domains . The most commonly reported mutation…
2. 多発性内分泌腫瘍2型の分類および遺伝学classification and genetics of multiple endocrine neoplasia type 2 [show details]
…disorder Met 918 is a critical component of the substrate recognition pocket in the tyrosine kinase catalytic core of the RET protein. In more than 50 percent of cases of MEN2B with codon 918 affected, mutations…
3. ファンコニー貧血の臨床症状と診断clinical manifestations and diagnosis of fanconi anemia [show details]
…called the FA core complex. This complex contains eight of the known FA proteins: FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL, and FANCM. Within this complex, FANCL acts as the catalytic component, functioning …
4. 一般的なB型肝炎ウイルス亜種の臨床的意義および分子学的特徴clinical significance and molecular characteristics of common hepatitis b virus variants [show details]
…patients with core promoter variant had significantly lower serum HBV DNA levels compared to those with wild type sequence in the core promoter region. A possible explanation was the selection of core promoter… relative to the catalytic site . The putative catalytic domain is believed to reside in the tyrosine-methionine-aspartate-aspartate…
5. 小児の双極性障害：補助的精神療法の有効性と中心的要素pediatric bipolar disorder efficacy and core elements of adjunctive psychotherapy [show details]
…which appears to be efficacious and is a core element of more elaborate and intensive psychotherapies (eg, family therapy). This topic reviews the efficacy and core elements of different adjunctive psychotherapies …

English Journal

Compound heterozygous mutations Glu502Lys and Met527Thr of the FXII gene in a patient with factor XII deficiency.

Zhang H, Liu S, Lin C, Luo S, Yang L, Jin Y, Zhu L, Wang M.
Hematology (Amsterdam, Netherlands). 2019 Dec;24(1)420-425.
To study the gene mutation of human coagulation factor XII (FXII) in a Chinese family with FXII deficiency and it will help us to understand the pathogenesis of this type of disease. The proband was a 50-year-old male who had a fracture of the right humerus. The routine presurgical coagulation test
PMID 30929639

The chemical diversity and structure-based discovery of allosteric modulators for the PIF-pocket of protein kinase PDK1.

Xu X, Chen Y, Fu Q, Ni D, Zhang J, Li X, Lu S.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)361-374.
Phosphoinositide-dependent protein kinase-1 (PDK1) is an important protein in mediating the PI3K-AKT pathway and is thus identified as a promising target. The catalytic activity of PDK1 is tightly regulated by allosteric modulators, which bind to the PDK1 Interacting Fragment (PIF) pocket of the kin
PMID 30734603

Virtual design of novel Plasmodium falciparum cysteine protease falcipain-2 hybrid lactone-chalcone and isatin-chalcone inhibitors probing the S2 active site pocket.

Allangba KNPG, Keita M, Kre N'Guessan R, Megnassan E, Frecer V, Miertus S.
Journal of enzyme inhibition and medicinal chemistry. 2019 Dec;34(1)547-561.
We report computer-aided design of new lactone-chalcone and isatin-chalcone (HLCIC) inhibitors of the falcipain-2 (PfFP-2). 3D models of 15 FP-2:HLCIC1-15 complexes with known observed activity (IC) were prepared to establish a quantitative structure-activity (QSAR) model and linear correlation betw
PMID 30696325