関: CCCP

WordNet

an abundant nonmetallic tetravalent element occurring in three allotropic forms: amorphous carbon and graphite and diamond; occurs in all organic compounds (同)C, atomic number 6
a copy made with carbon paper (同)carbon_copy
relating to or containing the carbonyl group (同)carbonylic
a compound containing metal combined with carbon monoxide
the 13th letter of the Roman alphabet (同)m
an extremely poisonous salt of hydrocyanic acid

PrepTutorEJDIC

『炭素』(化学記号は『C』) / 〈C〉炭素棒 / 〈C〉《時に〈U〉》=carbon paper
Mach number / mark[s] / Monsieur
シアン化物,(特に)青酸カリ

Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2016/02/23 14:04:15」(JST)

wiki en

Carbonyl cyanide m-chlorophenyl hydrazone (CCCP), is a chemical inhibitor of oxidative phosphorylation. It is a nitrile, hydrazone and protonophore. In general, CCCP causes the gradual destruction of living cells and death of the organism.^[1]^[2] The CCCP affects the protein synthesis reactions in seedling mitochondria.^[3] CCCP causes an uncoupling of the proton gradient that is established during the normal activity of electron carriers in the electron transport chain. The chemical acts essentially as an ionophore and reduces the ability of ATP synthase to function optimally.

References

^ J.W. Park; S.Y. Lee; J.Y. Yang; H.W. Rho; B.H. Park; S.N. Lim; J.S. Kim; H.R. Kim (1997). "Effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on the dimerization of lipoprotein lipase.". Biochimica et Biophysica Acta 1344 (2): 132–8. doi:10.1016/s0005-2760(96)00146-4. PMID 9030190.
^ D. Gášková; B. Brodská; A. Holoubek; K. Sigler (1999). "Factors and processes involved in membrane potential build-up in yeast: diS-C3(3) assay". The International Journal of Biochemistry & Cell Biology 31 (5): 575–584. doi:10.1016/S1357-2725(99)00002-3.
^ Y.M. Konstantinov; I.V. Subota; A.S. Arziev. "Protein synthesis in mitochondria under different redox conditions". Preprint of the Irkutsk Institute of Plant Physiology and Biochemistry.

This biochemistry article is a stub. You can help Wikipedia by expanding it.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. シアン化物中毒 cyanide poisoning
2. 化学テロ：化学兵器への曝露の診断および治療 chemical terrorism diagnosis and treatment of exposure to chemical weapons
3. 煙の吸入 smoke inhalation
4. 成人における中等度および重度熱傷の救急治療 emergency care of moderate and severe thermal burns in adults
5. 小児での潜在的に毒性を持つ植物の摂取による臨床症状および評価 clinical manifestations and evaluation of potentially toxic plant ingestions in children

English Journal

Identification of a multidrug efflux pump in Mycobacterium smegmatis.

Bansal A1, Mallik D1, Kar D1, Ghosh AS2.
FEMS microbiology letters.FEMS Microbiol Lett.2016 May 12. pii: fnw128. [Epub ahead of print]
Cell wall impermeability and active efflux of drugs are among the primary reasons for drug resistance in mycobacteria. Efflux pumps are tripartite membrane localized transport proteins that expel drug molecules outside the cells. Several of such efflux pumps are annotated in mycobacteria, but few ha
PMID 27190152

Secretion of D-alanine by Escherichia coli.

Katsube S1, Sato K2, Ando T3, Isogai E4, Yoneyama H5.
Microbiology (Reading, England).Microbiology.2016 May 6. doi: 10.1099/mic.0.000305. [Epub ahead of print]
Escherichia coli has an L-alanine export system that protects the cells from toxic accumulation of intracellular L-alanine in the presence of L-alanyl-L-alanine (L-Ala-L-Ala). When a D-amino acid dehydrogenase (DadA)-deficient strain was incubated with 6.0 mM L-Ala-L-Ala, we detected L-alanine and D
PMID 27166225

Peroxiredoxin 6 Is a Crucial Factor in the Initial Step of Mitochondrial Clearance and Is Upstream of the PINK1-Parkin Pathway.

Ma S1, Zhang X1, Zheng L1, Li Z1, Zhao X2, Lai W3, Shen H4, Lv J1, Yang G5, Wang Q1, Ji J1.
Antioxidants & redox signaling.Antioxid Redox Signal.2016 Mar 20;24(9):486-501. doi: 10.1089/ars.2015.6336. Epub 2016 Feb 19.
AIMS: PTEN-putative kinase 1 (PINK1)-Parkin-mediated mitophagy is crucial for the clearance of damaged mitochondria. However, the mechanisms underlying PINK1-Parkin-mediated mitophagy are not fully understood. The goal of this study is to identify new regulators and to elucidate the regulatory mecha
PMID 26560306

Japanese Journal

Hypoxia differentially modulates the activity of pacemaker and smooth muscle cells in the guinea pig stomach antrum

Nakamura Eri,Yokoi Tsuyoshi,Fukuta Hiroyasu,Iida Takao,Tanaka Yasuo,Yamamoto Yoshimichi,Suzuki Hikaru
Journal of Smooth Muscle Research 45(4), 149-166, 2009
… The increase in frequency of slow waves by hypoxia was prevented by cyclopiazonic acid (CPA) but not by carbonyl cyanide m-chlorophenyl-hydrazone (CCCP), potassium cyanide (KCN) or low-Ca solution. …
NAID 130000860937

A Study on the Regulation and Energy Requirements of Helicobacter pylori Motility and Its Inhibitors

KUSHIYA Koji,TANEIKE Ikue,NAKAGAWA Saori,ZHANG Hui-Min,GEJYO Fumitake,YAMAMOTO Tatsuo
Acta medica et biologica 52(4), 133-140, 2004-12
… pylori was observed at a swimming speed of around 70μm/s or more in vitro. … The addition of a proton-ionophore, carbonyl cyanide m-chlorophenyl hydrazone (CCCP), immediately inhibited the H. …
NAID 110004594265

Enantioselective Uptake of BOF-4272, a Xanthine Oxidase Inhibitor with a Chiral Sulfoxide, by Isolated Rat Hepatocytes

内藤真策,西村益浩
藥學雜誌 121(12), 989-994, 2001-12-01
… The K_m values for the S(-) and R(+) enantiomers were 59.3 and 25.7 μM, respectively, which was a significant difference (p<0.05). …
NAID 110003648504

「CCCP」

Carbonyl cyanide m-chlorophenyl hydrazone
Names
	IUPAC name [(3-chlorophenyl)hydrazono]malononitrile
	Systematic IUPAC name [(3-chlorophenyl)hydrazono]propanedinitrile
Identifiers
CAS Number	555-60-2
ChEBI	CHEBI:3259
ChEMBL	ChEMBL224214
ChemSpider	2504
Jmol interactive 3D	Image
KEGG	C11164
MeSH	CCCP
PubChem	2603
	InChI InChI=1S/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H Key: UGTJLJZQQFGTJD-UHFFFAOYSA-N ; InChI=1/C9H5ClN4/c10-7-2-1-3-8(4-7)13-14-9(5-11)6-12/h1-4,13H Key: UGTJLJZQQFGTJD-UHFFFAOYAQ ;
	SMILES Clc1cc(N\N=C(/C#N)C#N)ccc1 ;
Properties
Chemical formula	C9H5ClN4
Molar mass	204.616 g/mol
	Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
	verify (what is ?)
	Infobox references

　　[★]

カルボニルシアニドm-クロロフェニルヒドラゾン

関: carbonyl cyanide m-chlorophenyl hydrazone

「カルボニルシアニドm-クロロフェニルヒドラゾン」

　　[★]

英: carbonyl cyanide m-chlorophenyl hydrazone、CCCP

「med」

　　[★]

n.

医学

関: iatrology、medical、medical science、medicine

「mes」

　　[★]

comb form.

中央、中間、中位

ex.

mesonephros 中腎

「carbon」

　　[★]

炭素、カーボン

関: C、carbonic

「ms」

　　[★] ミリ秒

関: millisecond、msec

「M」

　　[★] メチオニン methionine 　　

[park97-1] J.W. Park; S.Y. Lee; J.Y. Yang; H.W. Rho; B.H. Park; S.N. Lim; J.S. Kim; H.R. Kim (1997). "Effect of carbonyl cyanide m-chlorophenylhydrazone (CCCP) on the dimerization of lipoprotein lipase.". Biochimica et Biophysica Acta 1344 (2): 132–8. doi:10.1016/s0005-2760(96)00146-4. PMID 9030190.

[brod99-2] D. Gášková; B. Brodská; A. Holoubek; K. Sigler (1999). "Factors and processes involved in membrane potential build-up in yeast: diS-C3(3) assay". The International Journal of Biochemistry & Cell Biology 31 (5): 575–584. doi:10.1016/S1357-2725(99)00002-3.

[irku-3] Y.M. Konstantinov; I.V. Subota; A.S. Arziev. "Protein synthesis in mitochondria under different redox conditions". Preprint of the Irkutsk Institute of Plant Physiology and Biochemistry.

リンク元	「CCCP」「カルボニルシアニドm-クロロフェニルヒドラゾン」
関連記事	「med」「mes」「carbon」「ms」「M」

匿名

検索

案内

案内

carbonyl cyanide m-chlorophenyl hydrazone