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- 関
WordNet
- give an artificially banal or sexual quality to
- temporary living quarters specially built by the army for soldiers; "wherever he went in the camp the men were grumbling" (同)encampment, cantonment, bivouac
- shelter for persons displaced by war or political oppression or for religious beliefs (同)refugee camp
- a site where care and activities are provided for children during the summer months; "city kids get to see the country at a summer camp" (同)summer camp
- a penal institution (often for forced labor); "China has many camps for political prisoners"
- temporary lodgings in the country for travelers or vacationers; "level ground is best for parking and camp areas"
- a group of people living together in a camp; "the whole camp laughed at his mistake"
- something that is considered amusing not because of its originality but because of its unoriginality; "the living room was pure camp"
- establish or set up a camp (同)camp down
- providing sophisticated amusement by virtue of having artificially (and vulgarly) mannered or banal or sentimental qualities; "they played up the silliness of their roles for camp effect"; "campy Hollywood musicals of the 1940s" (同)campy
- live in or as if in a tent; "Can we go camping again this summer?"; "The circus tented near the town"; "The houseguests had to camp in the living room" (同)encamp, camp out, bivouac, tent
- any of a large group of nitrogenous organic compounds that are essential constituents of living cells; consist of polymers of amino acids; essential in the diet of animals for growth and for repair of tissues; can be obtained from meat and eggs and milk and legumes; "a diet high in protein"
- a cellular structure that is postulated to exist in order to mediate between a chemical agent that acts on nervous tissue and the physiological response
PrepTutorEJDIC
- 〈C〉(軍隊・登山隊・探検隊などの)『野営地』 / 〈C〉〈U〉野営のテント,仮設小屋 / 〈U〉野営,キャンプ[生活];軍隊生活 / 〈C〉夏季キャンプ場,サマーキャンプ / 《集合的に》野営する人たち,キャンプする人たち / 〈C〉(主義・信条などを同じくする)同志たち,同じ陣営;同じ立場 / 『野営する』,キャンプ生活を送る《+『out』》
- =homosexual / (男性が)女々しい / すたれた,古めかしい
- 蛋白(たんばく)質
- =sense organ / 受信装置
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2014/11/30 22:51:01」(JST)
[Wiki en表示]
CAMP receptor protein |
Structure of the E. coli Cyclic AMP Receptor Protein.
|
Identifiers |
Symbol |
CRP |
Alt. symbols |
CAP |
Entrez |
947867 |
PDB |
1I5Z (RCSB PDB PDBe PDBj) |
RefSeq |
NP_417816.1 |
UniProt |
P0ACJ8 |
cAMP receptor protein (CRP; also known as catabolite activator protein, CAP) is a regulatory protein in bacteria. CRP protein binds cAMP, which causes a conformational change that allows CRP to bind tightly to a specific DNA site in the promoters of the genes it controls.[1][2] CRP then activates transcription through direct protein-protein interactions with RNA polymerase.[1][2]
The genes regulated by CRP are mostly involved in energy metabolism, such as galactose, citrate, or the PEP group translocation system.[3][4] In Escherichia coli, cyclic AMP receptor protein (CRP) can regulate the transcription of more than 100 genes.
The signal to activate CRP is the binding of cyclic AMP. Binding of cAMP to CRP leads to a long-distance signal transduction from the N-terminal cAMP-binding domain to the C-terminal domain of the protein, which is responsible for interaction with specific sequences of DNA.[5]
At "Class I" CRP-dependent promoters, CRP binds to a DNA site located upstream of core promoter elements and activates transcription through protein-protein interactions between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit.[1][2][6] At "Class II" CRP-dependent promoters, CRP binds to a DNA site that overlaps the promoter -35 element and activates transcription through two sets of protein-protein interactions: (1) an interaction between "activating region 1" of CRP and the C-terminal domain of RNA polymerase alpha subunit, and (2) an interaction between "activating region 2" of CRP and the N-terminal domain of RNA polymerase alpha subunit.[1][2] At "Class III" CRP-dependent promoters, CRP functions together with one or more "co-activator" proteins.[1][2]
At most CRP-dependent promoters, CRP activates transcription primarily or exclusively through a "recruitment" mechanism, in which protein-protein interactions between CRP and RNA polymerase assist binding of RNA polymerase to the promoter.[1]
References
- ^ a b c d e f Busby S., Ebright RH. (1999). "Transcription activation by catabolite activator protein (CAP)". J. Mol. Biol. 293 (2): 199–213. doi:10.1006/jmbi.1999.3161. PMID 10550204.
- ^ a b c d e Lawson C.L., Swigon D., Murakami K.S., Darst S.A., Berman H.M., Ebright RH. (2004). "Catabolite activator protein: DNA binding and transcription activation". Curr. Opin. Struct. Biol. 14 (1): 10–20. doi:10.1016/j.sbi.2004.01.012. PMC 2765107. PMID 15102444.
- ^ Weickert MJ, Adhya S (1993). "The galactose regulon of Escherichia coli". Mol. Microbiol. 10 (2): 245–51. doi:10.1111/j.1365-2958.1993.tb01950.x. PMID 7934815.
- ^ Bott M (1997). "Anaerobic citrate metabolism and its regulation in enterobacteria". Arch. Microbiol. 167 (2–3): 78–88. doi:10.1007/s002030050419. PMID 9133329.
- ^ Popovych, N.; Tzeng, S. -R.; Tonelli, M.; Ebright, R. H.; Kalodimos, C. G. (2009). "Structural basis for cAMP-mediated allosteric control of the catabolite activator protein". Proceedings of the National Academy of Sciences 106 (17): 6927–6932. doi:10.1073/pnas.0900595106. PMC 2678429. PMID 19359484. edit
- ^ Hudson, B. P.; Quispe, J.; Lara-Gonzalez, S.; Kim, Y.; Berman, H. M.; Arnold, E.; Ebright, R. H.; Lawson, C. L. (2009). "Three-dimensional EM structure of an intact activator-dependent transcription initiation complex". Proceedings of the National Academy of Sciences 106 (47): 19830–19835. doi:10.1073/pnas.0908782106. PMC 2775702. PMID 19903881. edit
UpToDate Contents
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English Journal
- SAMP8 mice have altered hippocampal gene expression in long term potentiation, phosphatidylinositol signaling, and endocytosis pathways.
- Armbrecht HJ, Siddiqui AM, Green M, Farr SA, Kumar VB, Banks WA, Patrick P, Shah GN, Morley JE.SourceGeriatric Research, Education and Clinical Center (GRECC), St Louis Veterans Affairs Medical Center, St Louis, MO, USA; Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO, USA; Department of Biochemistry and Molecular Biology, Saint Louis University School of Medicine, St Louis, MO, USA. Electronic address: hjarmbrec@aol.com.
- Neurobiology of aging.Neurobiol Aging.2014 Jan;35(1):159-68. doi: 10.1016/j.neurobiolaging.2013.07.018. Epub 2013 Aug 19.
- The senescence-accelerated mouse (SAMP8) strain exhibits decreased learning and memory and increased amyloid beta (Aβ) peptide accumulation at 12 months. To detect differences in gene expression in SAMP8 mice, we used a control mouse that was a 50% cross between SAMP8 and CD-1 mice and which showe
- PMID 23969180
- Phosphodiesterase 10A controls D1-mediated facilitation of GABA release from striato-nigral projections under normal and dopamine-depleted conditions.
- Mango D, Bonito-Oliva A, Ledonne A, Nisticò R, Castelli V, Giorgi M, Sancesario G, Fisone G, Berretta N, Mercuri NB.SourceIRCCS Fondazione Santa Lucia, Rome, Italy; Department of Systems Medicine, University of Rome Tor Vergata, Rome, Italy.
- Neuropharmacology.Neuropharmacology.2014 Jan;76 Pt A:127-36. doi: 10.1016/j.neuropharm.2013.08.010. Epub 2013 Aug 22.
- In the present study, we found that PDE10A inhibitor papaverine, alone or in combination with the D1 receptor agonist SKF38393, did not change spontaneous IPSCs (sIPSCs) frequency or amplitude in the substantia nigra pars reticulata (SNpr). An increase in frequency, but not in amplitude, of sIPSCs w
- PMID 23973317
- IVIG immunotherapy protects against synaptic dysfunction in Alzheimer's disease through complement anaphylatoxin C5a-mediated AMPA-CREB-C/EBP signaling pathway.
- Gong B, Pan Y, Zhao W, Knable L, Vempati P, Begum S, Ho L, Wang J, Yemul S, Barnum S, Bilski A, Gong BY, Pasinetti GM.SourceDepartment of Neurology, Center of Excellence for Novel Approaches to Neurotherapeutics, Mount Sinai School of Medicine, New York, NY 10029, United States.
- Molecular immunology.Mol Immunol.2013 Dec 31;56(4):619-29. doi: 10.1016/j.molimm.2013.06.016. Epub 2013 Aug 1.
- BACKGROUND: Complement component C5-derived C5a locally generated in the brain has been shown to protect against glutamate-induced neuronal apoptosis and beta-amyloid (Aβ) toxicity, but the mechanism is not clear. In this study, we tested the hypothesis that C5a influences upstream signal transduct
- PMID 23911420
Japanese Journal
- New evidence for the involvement of prostaglandin receptor EP4b in ovulation of the medaka, Oryzias latipes.
- Fujimori Chika,Ogiwara Katsueki,Hagiwara Akane,Takahashi Takayuki
- Molecular and cellular endocrinology 362(1-2), 76-84, 2012-10-15
- … A cDNA for a prostaglandin E(2) (PGE(2)) receptor subtype 4, EP4b (Ptger4b), was cloned from the medaka ovary. … The effect of PGE(2) was examined using COS-7 cells expressing the recombinant Ptger4b protein. … An increase in intracellular cAMP levels was observed when the cells were incubated with PGE(2), but the increase in cAMP levels was nullified by the addition of the EP4 antagonist GW627368X. …
- NAID 120004650807
- A new carbon catabolite repression mutation of Escherichia coli, mlc^*, and its use for producing isobutanol(MICROBIAL PHYSIOLOGY AND BIOTECHNOLOGY)
- Nakashima Nobutaka,Tamura Tomohiro
- Journal of bioscience and bioengineering 114(1), 38-44, 2012-07-00
- … Also, the mlc^* strain produced similar or greater amounts of isobutanol than other CCR-negative strains, ΔptsG and crp^* (crp^*, encoding the constitutive-active mutant of cAMP receptor protein). …
- NAID 110009479362
- The Inhibitory G Protein Gi Identified as Pertussis Toxin-Catalyzed ADP-Ribosylation
- Katada Toshiaki
- Biological and Pharmaceutical Bulletin 35(12), 2103-2111, 2012
- … Pertussis toxin (PTX) produced by Bordetella pertussis was first introduced by Ui and his colleagues in research on signal transduction under the name islet-activating protein in 1979, when the mechanism of toxin-induced stimulation of insulin release from pancreatic islets was reported in the rat. … The stimulatory effect of PTX in vivo results from the blockage of α2-adrenergic receptor-mediated inhibition of insulin release. …
- NAID 130002480519
Related Links
- Function of cAMP receptor protein from Thermus thermophilus HB8 Thermus thermophilus HB8 株由来の転写因子、cAMP レセプタータンパク質の機能 Akeo Shinkai 新海暁男 (SR System Biology Research Group, RIKEN Spring-8 ...
- Antiplatelet Effects of Caffeic Acid Due to Ca2+ MobilizationInhibition Via cAMP-Dependent Inositol-1, 4, 5-Trisphosphate Receptor Phosphorylation ...
Related Pictures
★リンクテーブル★
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- 英
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- cAMP receptor protein
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- cAMP receptor protein
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サイクリックAMP受容体、サイクリックAMPレセプター、cAMP受容体、cAMPレセプター
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- cyclic AMP receptor
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環状アデノシン一リン酸 サイクリックAMP 環状AMP adenosine 3',5'-cyclic monophosphate, cyclic AMP
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