Wikipedia preview

出典(authority):フリー百科事典『ウィキペディア（Wikipedia）』「2012/05/08 07:06:13」(JST)

wiki en

Butylscopolamine, also known as scopolamine butylbromide, butylhyoscine and hyoscine butylbromide, is a peripherally acting antimuscarinic, anticholinergic agent^[1] used as an abdominal-specific antispasmodic. It is a quaternary ammonium compound and a semisynthetic derivative of scopolamine. It is marketed under the trade name Buscopan by Boehringer Ingelheim GmbH, Germany, who also offer a combination of butylscopolamine and paracetamol, marketed under the name Buscopan Plus (in some countries, Buscopan Compositum).

Butylscopolamine is used to treat pain and discomfort caused by abdominal cramps, menstrual cramps, or other spasmodic activity in the digestive system. It is also effective at preventing bladder spasms. It is not an analgesic in the normal sense, since it doesn't 'mask' or 'cover over' the pain, but rather works to prevent painful cramps and spasms from occurring in the first place. The attachment of the butyl-bromide moiety effectively prevents the movement of this drug across the blood-brain barrier, effectively minimising undesirable CNS side-effects associated with scopolamine/hyoscine.

Medical uses

Butylscopolamine is used to treat cramping abdominal pain with some success.^[2]

Hyoscine butylbromide is effective in significantly reducing the duration of the first stage of labour, and it is not associated with any obvious adverse outcomes in mother or neonate.^[3]^[4]

Abuse

Butylscopolamine is not centrally active and has a low incidence of abuse.

References

^ Murakami, M.; Tomiyama, Y.; Hayakawa, K.; Akahane, M.; Ajisawa, Y.; Park, Y. C.; Ohnishi, N.; Sugiyama, T.; Kurita, T. (2000). "Effects of β-Adrenergic Stimulation on the Acutely Obstructed Ureter in Dogs" (pdf). Journal of Pharmacology and Experimental Therapeutics 292 (1): 67–75. PMID 10604932. http://jpet.aspetjournals.org/content/292/1/67.full.pdf.
^ Tytgat, G. N. (2007). "Hyoscine Butylbromide: A Review of its Use in the Treatment of Abdominal Cramping and Pain". Drugs 67 (9): 1343–1357. PMID 17547475.
^ BJOG. 2007 Dec;114(12):1542-6. Epub 2007 Sep 27.The effect of hyoscine butylbromide on the first stage of labour in term pregnancies.Samuels LA, Christie L, Roberts-Gittens B, Fletcher H, Frederick J.
^ Samuels LA, Christie L, Roberts-Gittens B, Fletcher H, Frederick J. (2007 Sep 27.). "The effect of hyoscine butylbromide on the first stage of labour in term pregnancies". BJOG. 12 114 (1542): 6. http://www.ncbi.nlm.nih.gov/pubmed/17903230.

External links

"Buscopan/Buscapina". Boehringer Ingelheim. http://www.buscopan.com.

UpToDate Contents

全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.

1. 遺伝性血管浮腫：急性発作の治療 hereditary angioedema treatment of acute attacks

English Journal

Effect of N-butylscopolammonium bromide on equine ileal smooth muscle activity in an ex vivo model.

Hart KA1, Sherlock CE1, Davern AJ1, Lewis TH1, Robertson TP1.
Equine veterinary journal.Equine Vet J.2015 Jul;47(4):450-5. doi: 10.1111/evj.12293. Epub 2014 May 26.
REASONS FOR PERFORMING STUDY: N-butylscopolammonium bromide (NBB) is an anticholinergic agent used to treat spasmodic colic in horses. Intestinal smooth muscle spasm also occurs in horses with intraluminal intestinal obstructions, such as ileal impactions. The antispasmodic effects of NBB may be use
PMID 24779926

Microangiopathy triggers, and inducible nitric oxide synthase exacerbates dextran sulfate sodium-induced colitis.

Saijo H1, Tatsumi N2, Arihiro S3, Kato T4, Okabe M2, Tajiri H5, Hashimoto H2.
Laboratory investigation; a journal of technical methods and pathology.Lab Invest.2015 Jul;95(7):728-48. doi: 10.1038/labinvest.2015.60. Epub 2015 May 4.
Ulcerative colitis (UC) is a representative clinical manifestation of inflammatory bowel disease that causes chronic gastrointestinal tract inflammation. Dextran sulfate sodium (DSS)-induced colitis mice have been used to investigate UC pathogenesis, and in this UC model, disturbance and impairment
PMID 25938626

Motility mapping as evaluation tool for bowel motility: initial results on the development of an automated color-coding algorithm in cine MRI.

Hahnemann ML1, Nensa F, Kinner S, Gerken G, Lauenstein TC.
Journal of magnetic resonance imaging : JMRI.J Magn Reson Imaging.2015 Feb;41(2):354-60. doi: 10.1002/jmri.24557. Epub 2014 Jan 8.
PURPOSE: To develop and implement an automated algorithm for visualizing and quantifying bowel motility using cine magnetic resonance imaging (MRI).MATERIALS AND METHODS: Four healthy volunteers as well as eight patients with suspected or diagnosed inflammatory bowel disease (IBD) underwent MR exami
PMID 24399576

Japanese Journal

Influence of N-butylscopolamine on SUV in FDG PET of the bowel

SANGHERA Bal,EMMOTT Jennifer,WELLSTED David,CHAMBERS Jane,WONG Wai-Lup
Annals of nuclear medicine 23(5), 471-478, 2009-07-01
NAID 10025136753

ブチルスコポラミン投与により抑制された胃運動に対する足三里穴鍼通電刺激の効果

清水奈宇留,智原栄一
自律神経 = The Autonomic nervous system 45(6), 233-241, 2008-12-15
NAID 10024836811

ドンペリドンと臭化ブチルスコポラミンの同時経口投与が低カロリー飲料の胃排出に与える影響について

白崎由佳子
日本臨床生理学会雑誌 = Japanese journal of applied physiology 38(6), 299-302, 2008-12-01
NAID 10025635565

Related Pictures

★リンクテーブル★

リンク元	「ブチルスコポラミン」「butylscopolammonium bromide」「scopolamine butylbromide」

「ブチルスコポラミン」

Butylscopolamine
Systematic (IUPAC) name
	[7(S)-(1α,2β,4β,5α,7β)]-9-butyl-7-(3-hydroxy-; 1-oxo-2-phenylpropoxy)-9-methyl-3-oxa-; 9-azonitricyclo[3.3.1.0(2,4)]nonane
Clinical data
Pregnancy cat.	B2 (AU)
Legal status	Pharmacy Only (S2) (AU) GSL (UK)
Routes	Oral, rectal, intravenous
Pharmacokinetic data
Bioavailability	<1%
Protein binding	Low
Half-life	5 hours
Excretion	Renal (50%) and fecal
Identifiers
CAS number	149-64-4
ATC code	A03BB01
PubChem	CID 160883
ChemSpider	16736107
UNII	2Z3E1OF81V
Chemical data
Formula	C21H30NO4+
Mol. mass	360.467 g/mol
SMILES	eMolecules & PubChem
	InChI InChI=1S/C21H30NO4.BrH/c1-3-4-10-22(2)17-11-15(12-18(22)20-19(17)26-20)25-21(24)16(13-23)14-8-6-5-7-9-14;/h5-9,15-20,23H,3-4,10-13H2,1-2H3;1H/q+1;/p-1/t15-,16-,17-,18+,19-,20+,22?;/m1./s1 ; Key:HOZOZZFCZRXYEK-GSWUYBTGSA-M ;
(what is this?) (verify);