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Sawayanagi Y, Sonobe T, Kawata H, Nambu N, Nagai T.
Chemical & pharmaceutical bulletin.Chem Pharm Bull (Tokyo).1984 Mar;32(3):1049-54.
PMID 6744479

[Concentration of 14C-1-butylbiguanide in plasma of diabetic patients and its elimination after administration of a new Galenical formulation (author's transl)].

Gutsche H, Blumenbach L, Losert W, Wiemann H.AbstractThe time course of 1-butylbiguanide concentration in plasma and the urinary and fecal elimination of the substance were measured in six female elimination of the substance were measured in six female diabetic patients after oral administration of 100 mg of 14C-1-butylibiguanide hydrochloride as Sindiatil. The mean maximum plasma concentration was 37 mug/100 ml and was reached after about 2 1/2 h. At least semi-maximum plasma concentrations (greater than or equal 18 mug/100 ml) were maintained between the 1st and 8th h after administration. Within 24 h 64% of the administered dose were eliminated (36% via the kidneys, 28% with the faeces). After 3 days a total of 80% had been eliminated, one-half each in urine and faeces, respectively. The average time taken for 50% of maximum renal elimination, and thus of the absorbed quantity, to be excreted was 7.2 h.
Arzneimittel-Forschung.Arzneimittelforschung.1976;26(6):1227-9.
The time course of 1-butylbiguanide concentration in plasma and the urinary and fecal elimination of the substance were measured in six female elimination of the substance were measured in six female diabetic patients after oral administration of 100 mg of 14C-1-butylibiguanide hydrochloride as Sind
PMID 989423

沢柳洋市,園部尚,川田裕溢,南部直樹,永井恒司
Chemical & pharmaceutical bulletin 32(3), 1049-1054, 1984-03-25
… Using buformin hydrochloride, a highly water-soluble drug, as a model drug, a sustainedrelease dosage form was developed. …
NAID 110003624860

酒井清,中谷真理子,山崎みどり
藥學雜誌 101(4), 354-359, 1981-04-25
… Buformin hydrochloride, glymidine sodium and glyclopyramide were used as a hypoglycemic agent. …
NAID 110003650156