ブシラミン
Wikipedia preview
出典(authority):フリー百科事典『ウィキペディア(Wikipedia)』「2017/10/29 23:13:29」(JST)
[Wiki en表示]
Bucillamine
|
|
Names |
IUPAC name
2-[(2-Methyl-2-sulfanylpropanoyl)amino]-3-sulfanylpropanoic acid[citation needed]
|
Identifiers |
CAS Number
|
|
3D model (JSmol)
|
- Interactive image
- Interactive image
|
ChemSpider |
|
KEGG |
|
MeSH |
bucillamine |
|
|
UNII |
|
InChI
-
InChI=1S/C7H13NO3S2/c1-7(2,13)6(11)8-4(3-12)5(9)10/h4,12-13H,3H2,1-2H3,(H,8,11)(H,9,10) Y
Key: VUAFHZCUKUDDBC-UHFFFAOYSA-N Y
|
SMILES
-
CC(C)(S)c(:[o]):[nH]C(CS)c(:[o]):[oH]
-
CC(C)(S)C(=O)NC(CS)C(O)=O
|
Properties |
Chemical formula
|
C7H13NO3S2 |
Molar mass |
223.31 g·mol−1 |
log P |
1.032 |
Acidity (pKa) |
3.012 |
Basicity (pKb) |
10.985 |
Pharmacology |
ATC code
|
M01CC02 (WHO) |
Related compounds |
Related Alkanoic acids
|
- Acetylcysteine
- Glycylglycine
- Iminodiacetic acid
- Nitrilotriacetic acid
- N-Oxalylglycine
- Tiopronin
- Oxalyldiaminopropionic acid
- gamma-Glutamylcysteine
|
Related compounds
|
|
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa).
|
Infobox references |
|
|
Bucillamine is an antirheumatic agent developed from tiopronin. It is mainly used in Japan and Korea. Activity is mediated by the two thiol groups that the molecule contains. Research done in USA showed positive transplant preservation properties.[1]
References
- ^ Amersi, F.; Nelson, S. K.; Shen, X. D.; Kato, H.; Melinek, J.; Kupiec-Weglinski, J. W.; Horwitz, L. D.; Busuttil, R. W.; Horwitz, M. A. (2002). "Bucillamine, a Thiol Antioxidant, Prevents Transplantation-Associated Reperfusion Injury" (pdf). Proceedings of the National Academy of Sciences. 99 (13): 8915–8920. PMC 124398 . PMID 12084933. doi:10.1073/pnas.132026099.
Specific antirheumatic products / DMARDs (M01C)
|
Quinolines |
|
Gold preparations |
- Sodium aurothiomalate
- Sodium aurothiosulfate
- Auranofin
- Aurothioglucose
- Aurotioprol
|
Other |
- Penicillamine #/Bucillamine
- Chloroquine #/Hydroxychloroquine
- Leflunomide
- Sulfasalazine #
- antifolate (Methotrexate #)
- thiopurine (Azathioprine) #
|
- #WHO-EM
- ‡Withdrawn from market
- Clinical trials:
- †Phase III
- §Never to phase III
|
UpToDate Contents
全文を閲覧するには購読必要です。 To read the full text you will need to subscribe.
- 1. 膜性腎症の原因および診断 causes and diagnosis of membranous nephropathy
English Journal
- Drug-induced kidney disease: a study of the Japan Renal Biopsy Registry from 2007 to 2015.
- Yokoyama H1, Narita I2, Sugiyama H3, Nagata M4, Sato H5, Ueda Y6, Matsuo S7.
- Clinical and experimental nephrology.Clin Exp Nephrol.2016 Oct;20(5):720-730. Epub 2015 Nov 21.
- INTRODUCTION: The Japan Renal Biopsy Registry (J-RBR) was started in 2007 by the Committee for the Standardization of Renal Pathological Diagnosis and the Committee for the Kidney Disease Registry of the Japanese Society of Nephrology. The purpose of this report is to clarify drug-induced kidney dis
- PMID 26590949
- New and Pipeline Drugs for Gout.
- Keenan RT1,2, Schlesinger N3.
- Current rheumatology reports.Curr Rheumatol Rep.2016 Jun;18(6):32. doi: 10.1007/s11926-016-0579-7.
- Gout is the most common inflammatory arthropathy in the western world. Affecting millions and accounting for lost wages, increased health care costs, and significant disability, it remains a burden for those afflicted, their families, and the health care system. Despite the availability of a number
- PMID 27097819
- [DMARDs (Focusing on iguratimod)].
- Ito S.
- Nihon rinsho. Japanese journal of clinical medicine.Nihon Rinsho.2016 Jun;74(6):948-54.
- Conventional synthetic disease modifying anti-rheumatic drugs (csDMARDs) other than methotrexate (MTX: anchor csDMARDs) are effective for single use, reinforcement of MTX, biologics and induction and maintenance of biologics-free condition. Newly developed iguratimod (IGU) does not suppress immunolo
- PMID 27311184
Japanese Journal
- ブシラミン内服により生じたInterstitial Granulomatous Drug Reactionの1例 (特集 薬疹・薬物障害)
- Drug-induced kidney disease: a study of the Japan Renal Biopsy Registry from 2007 to 2015
- 症例報告 ブシラミン投与により発症した乾癬型薬疹と思われる1例
- 臨床皮膚科 = Japanese journal of clinical dermatology 70(10), 761-766, 2016-09
- NAID 40020958519
Related Links
- ブシラミン(Bucillamine)の検索ならお薬検索QLife(キューライフ)。お医者さんが処方する処方薬と、薬局で買える市販薬(OTC)、の効果と副作用、写真、添付文書、保管方法等を掲載。商品名だけでなく一般名や剤形、色などからも検索 ...
- のサプライヤーのリストを取得する Bucillamine と同等の製品を ... Chemos GmbH ためのサプライヤです Bucillamine. 我々としてもN-[2-(1-Cyclohexen-1-yl)ethyl]-2-(4-methoxyphenyl)acetamideを販売しています。
Related Pictures
★リンクテーブル★
[★]
- 英
- bucillamine
- 商
- ブシラミン、ブシラント、ブシレート、リマチル、レマルク
- 関
- 抗リウマチ薬