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A method for the direct injection and analysis of small volume human blood spots and plasma extracts containing high concentrations of organic solvents using revered-phase 2D UPLC/MS.

Rainville PD1, Simeone JL, Root DS, Mallet CR, Wilson ID, Plumb RS.
The Analyst.Analyst.2015 Mar 21;140(6):1921-31. doi: 10.1039/c4an02090a.
The emergence of micro sampling techniques holds great potential to improve pharmacokinetic data quality, reduce animal usage, and save costs in safety assessment studies. The analysis of these samples presents new challenges for bioanalytical scientists, both in terms of sample processing and analy
PMID 25655051

Concentration-related response potentiometric titrations to study the interaction of small molecules with large biomolecules.

Hamidi-Asl E1, Daems D, De Wael K, Van Camp G, Nagels LJ.
Analytical chemistry.Anal Chem.2014 Dec 16;86(24):12243-9. doi: 10.1021/ac503385x. Epub 2014 Nov 25.
In the present paper, the utility of a special potentiometric titration approach for recognition and calculation of biomolecule/small-molecule interactions is reported. This approach is fast, sensitive, reproducible, and inexpensive in comparison to the other methods for the determination of the ass
PMID 25390494

Ambroxol for women at risk of preterm birth for preventing neonatal respiratory distress syndrome.

Gonzalez Garay AG1, Reveiz L, Velasco Hidalgo L, Solis Galicia C.
The Cochrane database of systematic reviews.Cochrane Database Syst Rev.2014 Oct 31;10:CD009708. doi: 10.1002/14651858.CD009708.pub2.
BACKGROUND: Respiratory distress syndrome (RDS) is caused by a deficiency of pulmonary surfactant (an active agent that keeps pulmonary alveoli open and facilitates the entry of air to the lungs, thus improving the oxygenation of the newborn).A number of interventions such as pulmonary surfactant an
PMID 25361381